Results 211 to 220 of about 198,281 (308)

Machine learning‐assisted clone selection for intensified cell culture processes

Biotechnology Progress, EarlyView.
Abstract Intensified fed‐batch processes are becoming increasingly prevalent among biomanufacturers due to their superior space–time yields relative to traditional, non‐intensified fed‐batch processes. However, the shift towards intensified manufacturing has unexpectedly made optimal clone selection more challenging.
Nicolas Wolnick, John Schmitt, Christian Siltanen, Julia Armstrong, Shannon Hendrick, Ariel Atchley, Brandon Downey   +6 more
wiley   +1 more source

Hydrogen Migration Enhances Proton‐Coupled Electron Transfer in an S‐Scheme Heterojunction for High‐Efficiency Photocatalysis

Carbon Energy, EarlyView.
Precisely directed built‐in electric field in an S‐scheme heterojunction synergizes photogenerated charge separation with interfacial proton migration, thus co‐localizing electrons and protons on the NOH surface and boosting proton‐coupled electron transfer kinetics in the rate‐determining hydrogen release step. ABSTRACT The kinetic bottleneck in solar‐
Qinhao Zhao, Yuxin Wang, Xuyu Yang, Shuhan Sun, Kai Li, Yanxian Jin, Huayue Zhu, Song Wang, Xiao Zhang, Xianqiang Xiong   +9 more
wiley   +1 more source

Auxiliary TARP Subunits Define AMPA Receptor Pharmacology and Function. [PDF]

J Xenobiot
Bdir S, Çapan İ, Hawash M, Servi S, Qneibi M.   +4 more
europepmc   +1 more source

Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks

Chemistry – A European Journal, EarlyView.
A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan, Ethan J. French, Emerenziana Runco, Chetan B. Dhakan, Jinwu Yan, Hiroshi Nakashima, Michael T. McMahon, Assaf A. Gilad, Christian T. Farrar   +8 more
wiley   +1 more source

The Glutamate-Glutathione axis in neuropsychiatric disorders and cancer: From shared mechanisms to non-invasive biomarkers. [PDF]

Redox Biol
Wang R, Li Y, Shi D, Huang H, Ren Z, Ge Y, Chang Y, Yan G.   +7 more
europepmc   +1 more source

Phosphorescent Iridium Hydrazinonicotinic Acid (HYNIC) Complexes That Bind to Prostate Specific Membrane Antigen: Potential Photodynamic Therapy of Prostate Cancer

Chemistry – A European Journal, EarlyView.
A phosphorescent iridium(III) complex has been prepared with a 6‐hydrazinonicotinic acid (HYNIC) ligand tethered to a lysine‐ureido‐glutamatic acid pharmacophore, which binds to an enzyme, called prostate‐specific membrane antigen (PSMA), which is overexpressed in prostate cancer.
La'El Kimchi, Emily R. McGowan, Katherine A. Morgan, Jonathan M. White, Trevor A. Smith, Stacey E. Rudd, Paul S. Donnelly   +6 more
wiley   +1 more source

Metabotropic Glutamate Receptor 3 Expression During Liver Disease Progression: Association with Inflammation and Cell Viability in Hepatocellular Carcinoma. [PDF]

Int J Mol Sci
García-Gaytán AC, Hernández-Abrego A, De Ita-Pérez D, de Los Ríos-Arellano E, Gámez E, Díaz-Muñoz M, Méndez I.   +6 more
europepmc   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Neuroglial-Breast Cancer Crosstalk Shapes the Brain Metastatic Niche. [PDF]

Cells
Hombach-Klonisch S, Hall E, Amin R, Fedora E, Vriend J, Pitz M, Klonisch T.   +6 more
europepmc   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source