Results 241 to 250 of about 301,762 (292)

All Organisms Can Be Anesthetized, but There's No Point?

BioEssays, EarlyView.
ABSTRACT Because of their interest in medicine, most studies on anesthesia have historically focused on the nervous systems of animals. This has often led to the neglect of the fact that all life forms have the potential to be anesthetized. Anesthetics target proteins, such as four‐domain voltage‐dependent Na+/Ca2⁺ channels (4D‐NaV/CaV) and glutamate ...
Lucia Sylvain‐Bonfanti, Delphine Arbelet‐Bonnin, Christophe Lalanne, Olivier Dellis, Patrice Meimoun, Patrick Laurenti, Etienne Grésillon, François Bouteau   +7 more
wiley   +1 more source

Functional deletion of α7 nicotinic acetylcholine receptor impairs Ca²⁺-dependent glutamatergic synaptic transmission by affecting both presynaptic and postsynaptic protein expression and function. [PDF]

Front Physiol
Cannata B, Sposito L, Albini M, Aceto G, Puliatti G, Lazzarino G, Ripoli C, Tropea MR, Puzzo D, Piacentini R, Grassi C.   +10 more
europepmc   +1 more source

Fusion Pores as Regulators of Quantal Size and Cellular Physiology

BioEssays, EarlyView.
During regulated exocytosis, membrane fusion regulatory factors act directly on SNAREs and membrane lipids to control fusion pore dynamics. This, in turn, leads to a differential amount of cargo release (referred to in this article as “quantal size”) across various cell types, thereby triggering distinct physiological cues.
Bhavya R. Bhaskar, Shahina Mazumdar, Sruthilaya Dayanandan, Debasis Das   +3 more
wiley   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Research progress in glioma-related epilepsy (Review). [PDF]

Biomed Rep
Chen X, Yang JZ, Kong LY, Li ZY, Tang F, Li ZQ.   +5 more
europepmc   +1 more source

GABAergic mechanisms of excitation and hypersynchrony in adult rat hippocampus [PDF]

, 2003
Uusisaari, Marylka
core  

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Membrane ATPases and Mitochondrial Proteins in Fetal Cerebellum After Exposure to L-Glutamate During Gestation. [PDF]

Membranes (Basel)
Tejero A, León-Navarro DA, Martín M.
europepmc   +1 more source

Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing [PDF]

, 2019
Huettner, James E, Wilding, Timothy J
core   +1 more source