Results 1 to 10 of about 230,640 (243)

Photocontrol of Endogenous Glycine Receptors In Vivo [PDF]

Cell Chemical Biology, 2020
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action.
Piotr Bregestovski, Piotr Bregestovski, Daria Ponomareva, Marat A. Mukhamedyarov, Daniel Wutz, Carme Rovira, Carme Rovira, Elena Petukhova, Karin Rustler, Mercedes Alfonso-Prieto, Mercedes Alfonso-Prieto, Miquel Bosch, Antoni Bautista-Barrufet, Franck Peiretti, Xavier Rovira, Pau Gorostiza, Burkhard König, Alexandre M. J. Gomila, Elvira Mukhametova, Elvira Mukhametova, Alba Nin-Hill, Galyna Maleeva   +21 more
openaire   +9 more sources

Allosteric modulation of glycine receptors [PDF]

British Journal of Pharmacology, 2011
Inhibitory (or strychnine sensitive) glycine receptors (GlyRs) are anion-selective transmitter-gated ion channels of the cys-loop superfamily, which includes among others also the inhibitory γ-aminobutyric acid receptors (GABA(A) receptors). While GABA mediates fast inhibitory neurotransmission throughout the CNS, the action of glycine as a fast ...
Hanns Ulrich Zeilhofer, Hanns Ulrich Zeilhofer, Gonzalo E. Yévenes   +2 more
openaire   +4 more sources

Positive Modulation of the Glycine Receptor by Means of Glycine Receptor–Binding Aptamers [PDF]

SLAS Discovery, 2015
According to the gate control theory of pain, the glycine receptors (GlyRs) are putative targets for development of therapeutic analgesics. A possible approach for novel analgesics is to develop a positive modulator of the glycine-activated Cl(-) channels.
Shalaly, Nancy Dekki, Aneiros, Eduardo, Blank, Michael, Mueller, Johan, Nyman, Eva, Blind, Michael, Dabrowski, Michael A, Andersson, Christin V, Sandberg, Kristian   +8 more
openaire   +4 more sources

Glycine receptors and brain development [PDF]

Frontiers in Cellular Neuroscience, 2013
Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult. However, these receptors are also expressed in upper regions of the central nervous system, where they participate in ...
Ariel eAvila, Ariel eAvila, Ariel eAvila, Laurent eNguyen, Laurent eNguyen, Laurent eNguyen, Jean-Michel eRigo   +6 more
openaire   +5 more sources

Cesium activates the neurotransmitter receptor for glycine [PDF]

Frontiers in Molecular Neuroscience, 2023
The monovalent cations sodium and potassium are crucial for the proper functioning of excitable cells, but, in addition, other monovalent alkali metal ions such as cesium and lithium can also affect neuronal physiology. For instance, there have been recent reports of adverse effects resulting from self-administered high concentrations of cesium in ...
Steffen Fricke, Magnus Harnau, Florian Hetsch, Haoran Liu, Haoran Liu, Julia Leonhard, Anna Eylmann, Pina Knauff, Han Sun, Han Sun, Marcus Semtner, Jochen C. Meier   +11 more
openaire   +4 more sources

Inhibitory Glycine Receptors: An Update [PDF]

Journal of Biological Chemistry, 2012
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR ...
Dutertre, Sebastien, Becker, Cord-Michael, Betz, Heinrich   +2 more
openaire   +6 more sources

Glycine and glycine receptor signalling in non-neuronal cells [PDF]

Frontiers in Molecular Neuroscience, 2009
Glycine is an inhibitory neurotransmitter acting mainly in the caudal part of the central nervous system. Besides this neurotransmitter function, glycine has cytoprotective and modulatory effects in different non-neuronal cell types. Modulatory effects were mainly described in immune cells, endothelial cells and macroglial cells, where glycine ...
Van den Eynden, J, Saheb Ali, S, Horwood, N, Carmans, S, Brone, B, Hellings, N, Steels, P, Harvey, Robert J, Rigo, J M   +8 more
openaire   +7 more sources

Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]

, 2007
Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D., Groot-Kormelink, P., Plested, A.J.R., Sivilotti, L.G.   +3 more
core   +2 more sources

A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue [PDF]

, 2008
Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-{pi} interaction with the agonist, whereas in GABAA receptors, a Tyr performs this role.
Dougherty, Dennis A., Hanek, Ariele P., Lester, Henry A., Lummis, Sarah C. R., Lynch, Joseph W., Millen, Kat S., Pless, Stephan A.   +6 more
core   +2 more sources

Zinc modulation of glycine receptors [PDF]

Neuroscience, 2011
Glycine receptors are widely expressed in the mammalian central nervous system, and previous studies have demonstrated that glycine receptors are modulated by endogenous zinc. Zinc is concentrated in synaptic vesicles in several brain regions but is particularly abundant in the hippocampus and olfactory bulb.
Paul Q. Trombley, Laura J. Blakemore, Brook J. Hill   +2 more
openaire   +4 more sources