Glycine receptors and brain development [PDF]
Frontiers in Cellular Neuroscience, 2013 Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. There, they are mainly involved in motor control and pain perception in the adult.
Ariel eAvila +6 more
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Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus [PDF]
BiomedicinesBackground/Objectives: The neurotransmitter glycine is involved in several physiological and pathological conditions in the Central Nervous System. Different biological structures, including glycine receptors and transporters, are under study as targets ...
Luca Raiteri +3 more
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Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors [PDF]
BMC Neuroscience, 2009 Background N-methyl-D-aspartate receptors (NMDARs) are the most complex of ionotropic glutamate receptors (iGluRs). Subunits of this subfamily assemble into heteromers, which – depending on the subunit combination – may display very different ...
Orth Angela +2 more
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The involvement of GABA-rho receptors in regulating ethanol-induced elevation of dopamine, glycine and taurine within the nucleus accumbens of Wistar rats [PDF]
Frontiers in PharmacologyIntroductionAlcohol use disorder (AUD) causes significant morbidity and mortality globally. Ethanol’s rewarding and reinforcing effects are attributed to activation of the mesolimbic dopamine system, increasing accumbal dopamine release. While activation
Davide Cadeddu +7 more
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Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in Xenopus oocytes [PDF]
Computational and Structural Biotechnology JournalThe relationship between oxidative stress and glycine receptors is complex, involving multiple mechanisms through which reactive oxygen species can modify glycine receptor function. Understanding these interactions is essential for developing therapeutic
Sanung Eom +9 more
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The GluN3-containing NMDA receptors [PDF]
ChannelsN-methyl-D-aspartate receptors (NMDARs) are heterotetrameric ion channels that play crucial roles in brain function. Among all the NMDAR subtypes, GluN1-N3 receptors exhibit unique agonist binding and gating properties.
Kunlong Xiong +4 more
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Adrenergic pathways in glycine-mediated feeding behavior: Evidence from layer chickens [PDF]
Poultry ScienceGlycinergic and adrenergic systems are integral to the regulation of meal consumption in avian species; however, the interactions between these systems have not been previously documented. This investigation was conducted to explore the interplay between
Hamed Zarei +2 more
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Glycine and glycine receptor signalling in non-neuronal cells [PDF]
Frontiers in Molecular Neuroscience, 2009 Glycine is an inhibitory neurotransmitter acting mainly in the caudal part of the central nervous system. Besides this neurotransmitter function, glycine has cytoprotective and modulatory effects in different non-neuronal cell types.
Jimmy Van Den Eynden +8 more
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Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits. [PDF]
PLoS ONE, 2012 BACKGROUND: Human fetal midbrain-derived neural progenitor cells (NPCs) may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease.
Florian Wegner +7 more
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Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors? [PDF]
PeerJ, 2013 NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors.
Roland Baur, Jürg Gertsch, Erwin Sigel
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