Results 271 to 280 of about 2,744,319 (336)
Some of the next articles are maybe not open access.
Encyclopedia of Biological Chemistry III, 2021
T. Lynagh, B. Laube, J. Schaffer
semanticscholar +2 more sources
T. Lynagh, B. Laube, J. Schaffer
semanticscholar +2 more sources
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
Nature, 2002J. Chatterton +12 more
exaly +2 more sources
Pharmacology & Therapeutics, 1997
The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective transmembrane channel, which is predominantly expressed in the spinal cord and brain stem. We review the pharmacological and physiological properties of the GlyR and relate this
Rajendra, S, Lynch, JW, Schofield, PR
openaire +3 more sources
The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective transmembrane channel, which is predominantly expressed in the spinal cord and brain stem. We review the pharmacological and physiological properties of the GlyR and relate this
Rajendra, S, Lynch, JW, Schofield, PR
openaire +3 more sources
General Pharmacology: The Vascular System, 1978
Abstract 1. Recent studies aimed at elucidating synaptic glycine-receptors have been reviewed. 2. Biochemical and iontophoretic findings have revealed that such receptors exist in several regions of the vertebrate CNS. 3. Subcellular studies with labelled strychnine and glycine have revealed that strychnine does not interact directly with glycine ...
openaire +2 more sources
Abstract 1. Recent studies aimed at elucidating synaptic glycine-receptors have been reviewed. 2. Biochemical and iontophoretic findings have revealed that such receptors exist in several regions of the vertebrate CNS. 3. Subcellular studies with labelled strychnine and glycine have revealed that strychnine does not interact directly with glycine ...
openaire +2 more sources
Glycine binding primes NMDA receptor internalization
Nature, 2003NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory ligand-gated ion channel with prominent roles in physiological and disease processes in the central nervous system. Recognition that glycine potentiates NMDAR-mediated currents as well as being a requisite co-agonist of the NMDAR subtype of 'glutamate' receptor ...
Lorraine V Kalia +2 more
exaly +3 more sources
Glycine Receptor Drug Discovery
2017Postsynaptic glycine receptor (GlyR) chloride channels mediate inhibitory neurotransmission in the spinal cord and brain stem, although presynaptic and extrasynaptic GlyRs are expressed more widely throughout the brain. In humans, GlyRs are assembled as homo- or heteromeric pentamers of α1-3 and β subunits. GlyR malfunctions have been linked to a range
Lynch, Joseph W. +3 more
openaire +3 more sources
The inhibitory neuronal glycine receptor
BioEssays, 1994AbstractGlycine is a major inhibitory neurotransmitter in the spinal cord and in the brain stem, where it acts by activating a chloride conductance. The postsynaptic glycine receptor has been purified and contains two transmembrane subunits of 48 kDa (α) and 58 kDa (β), and a peripheral membrane protein of 93 kDa.
C, Béchade, C, Sur, A, Triller
openaire +2 more sources
Journal of Neurophysiology, 2005
Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
openaire +2 more sources
Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
openaire +2 more sources
1985
In the vertebrate CNS, many different compounds including acetylcholine, catecholamines, peptides, and amino acids have been identified as bona fide or candidate neurotransmitter substances. Amongst these the amino acids glycine and GABA have been particularly well characterized.
H. Betz +4 more
openaire +1 more source
In the vertebrate CNS, many different compounds including acetylcholine, catecholamines, peptides, and amino acids have been identified as bona fide or candidate neurotransmitter substances. Amongst these the amino acids glycine and GABA have been particularly well characterized.
H. Betz +4 more
openaire +1 more source