Results 281 to 290 of about 3,076,380 (339)

In vitro interaction of the glycine receptor with the leptin receptor

Physiology & Behavior, 2002
The coordination and regulation of electrical signals across excitable cells is a complex, dynamic phenomenon requiring, in part, the interaction of ion channels with cellular constituents. The intracellular loops or domains of many ion channel subunits have been shown to specifically bind other cellular components that act in receptor targeting ...
John F, Leite, Brian, Gribble, Norman, Randolph, Michael, Cascio   +3 more
openaire   +2 more sources

Effects of GABA Receptor Antagonists on Retinal Glycine Receptors and on Homomeric Glycine Receptor Alpha Subunits

Journal of Neurophysiology, 2005
Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
openaire   +2 more sources

Glycine Receptor Drug Discovery

2017
Postsynaptic glycine receptor (GlyR) chloride channels mediate inhibitory neurotransmission in the spinal cord and brain stem, although presynaptic and extrasynaptic GlyRs are expressed more widely throughout the brain. In humans, GlyRs are assembled as homo- or heteromeric pentamers of α1-3 and β subunits. GlyR malfunctions have been linked to a range
Lynch, Joseph W., Zhang, Yan, Talwar, Sahil, Estrada-Mondragon, Argel   +3 more
openaire   +4 more sources

Glycine receptors

British Journal of Pharmacology, 2006
S P H Alexander, A Mathie, J A Peters
  +4 more sources

Insulin Increases the Potency of Glycine at Ionotropic Glycine Receptors

Molecular Pharmacology, 2007
The mechanisms by which insulin modulates neuronal plasticity and pain processes remain poorly understood. Here we report that insulin rapidly increases the function of glycine receptors in murine spinal neurons and recombinant human glycine receptors expressed in human embryonic kidney cells.
Valerie B, Caraiscos, Robert P, Bonin, J Glen, Newell, Elzbieta, Czerwinska, John F, Macdonald, Beverley A, Orser   +5 more
openaire   +2 more sources

A metabotropic receptor for glycine

Nature Reviews Neuroscience, 2023
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Gathering Glycine Receptors at Synapses

Science, 1998
Neurons send their signals to the next neuron by shooting neurotransmitters across the intracellular gulf to a cluster of receptors on the downstream neuron. As discussed by Froehner in his Perspective, these receptors are held in place by so-called scaffolding proteins on the inside of the cell. A new example of such proteins is reported on page [1321]
openaire   +2 more sources

Hijacking of GABAA Receptors by Mutant Glycine Receptors

Trends in Molecular Medicine, 2019
Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al.
openaire   +3 more sources

Glycine Transporters and Its Coupling with NMDA Receptors.

Advances in neurobiology, 2017
F. Zafra, I. Ibáñez, D. Bartolomé-Martín, Dolores Piniella, Marina Arribas-Blázquez, C. Giménez   +5 more
semanticscholar   +1 more source

Regulation of Excitation by Glycine Receptors

2007
Our knowledge of glycine receptor (GlyR) regulation of excitation has advanced significantly in recent years. GlyRs are widespread in the CNS, are heterogeneous, and undergo developmental changes. Activation of GlyRs of immature neurons induces outflow of Cl( - ), membrane depolarization, neuronal excitation, calcium influx, and transmitter release, in
openaire   +2 more sources