Results 71 to 80 of about 2,728,154 (336)

Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]

, 2004
Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Glycine Receptors in Spinal Nociceptive Control—An Update

Biomolecules, 2021
Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain states. Restoring proper synaptic inhibition is a well-established rational therapeutic approach explored by several pharmaceutical companies.
Hanns Ulrich Zeilhofer, Karolina Werynska, Jacinthe Gingras, Gonzalo E. Yévenes   +3 more
doaj   +1 more source

Pathologically Activated Neuroprotection via Uncompetitive Blockade of \u3cem\u3eN\u3c/em\u3e-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin [PDF]

, 2010
Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders.
Fu, Hongjun, Han, Yifan, Huang, Pingbo, Li, Chaoying, Li, Fushun, Li, Wenming, Luo, Jialie, Ma, Dik-Lung, Pang, Yuanping, Peoples, Robert W., Tang, Jing, Wang, Qinwen, Xia, Jun, Zhao, Yuming   +13 more
core   +1 more source

Positive Modulation of the Glycine Receptor by Means of Glycine Receptor–Binding Aptamers [PDF]

SLAS Discovery, 2015
According to the gate control theory of pain, the glycine receptors (GlyRs) are putative targets for development of therapeutic analgesics. A possible approach for novel analgesics is to develop a positive modulator of the glycine-activated Cl(-) channels.
Shalaly ND, Aneiros E, Blank M, Mueller J, Nyman E, Blind M, Dabrowski MA, Andersson CV, Sandberg K   +8 more
openaire   +5 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

Journal of Experimental Medicine, 2012
Systemic and intrathecal administration of derivatives of a nonpsychoactive component of marijuana significantly suppresses chronic inflammatory and neuropathic pain, without causing analgesic tolerance, in several rodent models.
W. Xiong, Tanxing Cui, K. Cheng, Fei Yang, Shao-Rui Chen, D. Willenbring, Y. Guan, H. Pan, Ke Ren, Yan Xu, Li Zhang   +10 more
semanticscholar   +1 more source

Gephyrin, the enigmatic organizer at GABAergic synapses

Frontiers in Cellular Neuroscience, 2012
GABAA receptors are clustered at synaptic sites to achieve a high density of postsynaptic receptors opposite the input axonal terminals. This allows an efficient propagation of GABA mediated signals, which mostly result in neuronal inhibition.
Verena Eva Tretter, Jayanta eMukherjee, Hans Michael Maric, Hermann eSchindelin, Werner eSieghart, Stephen J. Moss   +5 more
doaj   +1 more source

Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules [PDF]

, 2016
Ocean acidification is a global challenge that faces marine organisms in the near future with a predicted rapid drop in pH of up to 0.4 units by the end of this century.
Adamo, Bode, Bopp, Briffa, Brown, Browne, Clements, Compton, Crothers, Darnell, Decho, Dodd, Fabry, Forward, Grimme, Grimme, Halgren, Hall-Spencer, Hardege, Hardege, Hay, Hayden, Haye, Hehre, Henry, Hunter, Jensen, Jensen, Jensen, Kim, Klamt, Kratt, Kutzelnigg, Leduc, Lemly, Lide, Lodewyk, McDonald, McNeil, Munday, Munday, Neese, Neese, Nilsson, O'Boyle, Perdew, Pettis, Piotto, Po, Pörtner, R Core Team, Reinsel, Reisert, Rittschof, Rittschof, Rittschof, Rittschof, Sklenář, Steiger, Tegtmeyer, Tierney, Vries, Weigend, Wishart, Wittmann, Wyatt, Wyatt, Wyatt, Zimmer, Zimmer-Faust   +69 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source