Results 171 to 180 of about 51,381 (211)
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Biochemical and Biophysical Research Communications, 2018
Granulocyte colony-stimulating factor (G-CSF) receptor (G-CSFR) is a type I cytokine receptor which is involved in hematopoietic cell maturation. G-CSFR has three putative C-mannosylation sites at W253, W318, and W446; however, it is not elucidated whether G-CSFR is C-mannosylated or not.
Kei, Otani +6 more
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Granulocyte colony-stimulating factor (G-CSF) receptor (G-CSFR) is a type I cytokine receptor which is involved in hematopoietic cell maturation. G-CSFR has three putative C-mannosylation sites at W253, W318, and W446; however, it is not elucidated whether G-CSFR is C-mannosylated or not.
Kei, Otani +6 more
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Urology, 2007
A significant fraction of invasive bladder carcinomas express both granulocyte colony-stimulating factor (G-CSF) and granulocyte colony-stimulating factor receptor (G-CSFR). We sought to determine whether G-CSF/G-CSFR signaling promotes survival and growth of bladder cancer cells.
Arup, Chakraborty, Sushovan, Guha
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A significant fraction of invasive bladder carcinomas express both granulocyte colony-stimulating factor (G-CSF) and granulocyte colony-stimulating factor receptor (G-CSFR). We sought to determine whether G-CSF/G-CSFR signaling promotes survival and growth of bladder cancer cells.
Arup, Chakraborty, Sushovan, Guha
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Human granulocyte colony‐stimulating factor receptors in acute myelogenous leukemia
European Journal of Haematology, 1991Abstract: Human granulocyte colony‐stimulating factor (G‐CSF) receptors on human acute leukemia cells were investigated using human G‐CSF iodolabeled by the lactoperoxidase method. Among various human leukemic cell lines, only cells of myelogenous lineage including HL‐60, THP‐1 and U937 had one type of high‐affinity receptor for G‐CSF, as shown by ...
S, Kondo +4 more
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Biochemical and Biophysical Research Communications, 1988
We have made a mutein of human G-CSF with more stable, and potent biological activity. Using 125 I-labeled mutein human G-CSF, high affinity binding sites were identified on human circulating neutrophils. Receptor number per cell was 560 with a Kd of 250 pM. The human G-CSF receptor was identified as a single subunit protein of Mr approximately 150,000.
H, Uzumaki +5 more
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We have made a mutein of human G-CSF with more stable, and potent biological activity. Using 125 I-labeled mutein human G-CSF, high affinity binding sites were identified on human circulating neutrophils. Receptor number per cell was 560 with a Kd of 250 pM. The human G-CSF receptor was identified as a single subunit protein of Mr approximately 150,000.
H, Uzumaki +5 more
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Granulocyte colony-stimulating factor receptor: Stimulating granulopoiesis and much more
The International Journal of Biochemistry & Cell Biology, 2009The granulocyte colony-stimulating factor receptor (G-CSFR) plays an important role in the production, survival and activation of neutrophilic granulocytes during both normal and emergency hematopoiesis. The G-CSFR also participates in the development of other myeloid lineages, the mobilization of hematopoietic stem cells and myeloid cell migration ...
Clifford, Liongue +3 more
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Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor
The Journal of Immunology, 1992Abstract The human chromosomal gene for the granulocyte CSF (G-CSF) receptor was molecularly cloned from a human gene library. The gene is about 16.5 kb long, and present in a single copy per haploid human genome. The human G-CSF receptor gene consists of 17 exons, and the sequences of exons are completely identical to those of cDNAs ...
Y, Seto, R, Fukunaga, S, Nagata
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Journal of Biochemistry, 1997
We have previously shown that the extracellular domain of granulocyte-colony stimulating factor receptor (soluble G-CSFR), prepared from CHO cell conditioned media, dimerizes upon binding its ligand, G-CSF. The most stable ligand-receptor complex occurs at a 2:2 stoichiometry, unlike the growth hormone and erythropoietin systems.
T P, Horan +4 more
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We have previously shown that the extracellular domain of granulocyte-colony stimulating factor receptor (soluble G-CSFR), prepared from CHO cell conditioned media, dimerizes upon binding its ligand, G-CSF. The most stable ligand-receptor complex occurs at a 2:2 stoichiometry, unlike the growth hormone and erythropoietin systems.
T P, Horan +4 more
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European Journal of Biochemistry, 1994
The high‐affinity granulocyte‐macrophage‐colony‐stimulating‐factor (GM‐CSF) receptor (R) is composed of at least two subunits, termed α and β. The α subunit is crucial for initiating ligand/receptor interaction and for ligand specificity. The experiments reported in this study sought to identify the domains of human (h)GM‐CSF which are responsible for ...
C B, Brown, C E, Pihl, K, Kaushansky
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The high‐affinity granulocyte‐macrophage‐colony‐stimulating‐factor (GM‐CSF) receptor (R) is composed of at least two subunits, termed α and β. The α subunit is crucial for initiating ligand/receptor interaction and for ligand specificity. The experiments reported in this study sought to identify the domains of human (h)GM‐CSF which are responsible for ...
C B, Brown, C E, Pihl, K, Kaushansky
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Cancer research, 1992
Granulocyte colony-stimulating factor (G-CSF) receptors on the gated leukemic blast cells from newly diagnosed patients with acute leukemia or crisis of chronic myelogenous leukemia were investigated using flow cytometric detection. Surface marker analysis and cytochemical studies were conducted simultaneously to characterize the blast cells.
K, Shimoda +9 more
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Granulocyte colony-stimulating factor (G-CSF) receptors on the gated leukemic blast cells from newly diagnosed patients with acute leukemia or crisis of chronic myelogenous leukemia were investigated using flow cytometric detection. Surface marker analysis and cytochemical studies were conducted simultaneously to characterize the blast cells.
K, Shimoda +9 more
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The Granulocyte Colony-Stimulating Factor Receptor and Its Role in Disorders of Granulopoiesis
Leukemia & Lymphoma, 1998The granulocyte colony-stimulating factor receptor (G-CSFR) critically regulates granulopoiesis. Defects in G-CSFR expression due to targeted disruption of the G-CSFR gene or the genes for the transcription factors C/EBPalpha and PU.1 result in decreases in hematopoietic progenitor cell numbers and neutropenia.
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