Results 1 to 10 of about 42,332 (197)

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Frontiers in Pharmacology, 2021
This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann, Uwe Kirchhefer, Stefan Dhein, Britt Hofmann, Ulrich Gergs   +4 more
doaj   +2 more sources

Changes in Histamine Receptors (H1, H2, and H3) Expression in Rat Medial Vestibular Nucleus and Flocculus after Unilateral Labyrinthectomy: Histamine Receptors in Vestibular Compensation. [PDF]

PLoS ONE, 2013
Vestibular compensation is the process of behavioral recovery following peripheral vestibular lesion. In clinics, the histaminergic medicine is the most widely prescribed for the treatment of vertigo and motion sickness, however, the molecular mechanisms
Liuqing Zhou, Wen Zhou, Sulin Zhang, Bo Liu, Yangming Leng, Renhong Zhou, Weijia Kong   +6 more
doaj   +2 more sources

Remission maintenance in acute myeloid leukemia: impact of functional histamine H2 receptors expressed by leukemic cells

Haematologica, 2012
Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 has been shown to improve leukemia-free survival in acute myeloid leukemia in a phase III trial.
Johan Aurelius, Anna Martner, Mats Brune, Lars Palmqvist, Markus Hansson, Kristoffer Hellstrand, Fredrik B. Thoren   +6 more
doaj   +2 more sources

Physiological implications of biased signaling at histamine H2 receptors.

Frontiers in Pharmacology, 2015
Histamine mediates numerous functions acting through its four receptor subtypes all belonging to the large family of seven transmembrane G-protein coupled receptors (GPCRs).
Natalia eAlonso, Natalia eAlonso, Carlos Daniel Zappia, Carlos Daniel Zappia, Maia eCabrera, Maia eCabrera, Carlos Alberto Davio, Carlos Alberto Davio, Carlos Alberto Davio, Carina eShayo, Carina eShayo, Federico eMonczor, Federico eMonczor, Natalia Cristina Fernandez, Natalia Cristina Fernandez   +14 more
doaj   +2 more sources

Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy

Life
Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders.
Erwen Kou, Xiaobei Zhang, Baiping Dong, Bo Wang, Yuanjie Zhu   +4 more
doaj   +2 more sources

Histamine Excites Rat Superior Vestibular Nuclear Neurons via Postsynaptic H1 and H2 Receptors in vitro

Neurosignals, 2012
The superior vestibular nucleus (SVN), which holds a key position in vestibulo-ocular reflexes and nystagmus, receives direct hypothalamic histaminergic innervations.
Qian-Xing Zhuang, Yong-Hui Wu, Guan-Yi Wu, Jing-Ning Zhu, Jian-Jun Wang   +4 more
doaj   +2 more sources

Modulation of vestibular function and receptor expression by experimental hypergravity in a rat model [PDF]

Scientific Reports
Motion sickness develops because of a mismatch or conflict between the information gathered from the visual input, somatosensory input, and the vestibular system. Altered gravity can cause motion sickness while traveling in space. In this study, we aimed
Jin Sil Choi, Ji Eun Hong, Yoon Kun Jung, Kyu-Sung Kim, Hyun Ji Kim   +4 more
doaj   +2 more sources

Human histamine H2 receptors can initiate cardiac arrhythmias in a transgenic mouse

Naunyn-Schmiedeberg's Archives of Pharmacology, 2021
Histamine is known to lead to arrhythmias in the human heart. A mouse model to mimic these effects has hitherto not been available but might be useful to study the mechanism(s) of H2-histamine receptor-induced arrhythmias and may support the search for ...
U. Gergs, J. Weisgut, K. Griethe, N. Mißlinger, U. Kirchhefer, J. Neumann   +5 more
semanticscholar   +1 more source

Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans

Science Advances, 2021
Histamine H1 and H2 receptors regulate multiple health-promoting adaptations to exercise training. Exercise training is a powerful strategy to prevent and combat cardiovascular and metabolic diseases, although the integrative nature of the training ...
Thibaux Van der Stede, L. Blancquaert, F. Stassen, I. Everaert, Ruud van Thienen, C. Vervaet, L. Gliemann, Y. Hellsten, W. Derave   +8 more
semanticscholar   +1 more source

Histamine can be Formed and Degraded in the Human and Mouse Heart

Frontiers in Pharmacology, 2021
Histamine is metabolized by several enzymes in vitro and in vivo. The relevance of this metabolism in the mammalian heart in vivo is unclear. However, histamine can exert positive inotropic effects (PIE) and positive chronotropic effects (PCE) in humans ...
Joachim Neumann, Juliane M. Grobe, Jacqueline Weisgut, Hubert G. Schwelberger, Wieslawa Agnieszka Fogel, Margaréta Marušáková, Hartmut Wache, Heike Bähre, Igor B. Buchwalow, Stefan Dhein, Britt Hofmann, Uwe Kirchhefer, Ulrich Gergs   +12 more
doaj   +1 more source