Results 21 to 30 of about 42,332 (197)

Expanding the Immunologic and Neuronal Landscape of IgE-Mediated Anaphylaxis. [PDF]

Immunol Rev
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Biswas R, Fried JM, Curotto de Lafaille MA.   +2 more
europepmc   +2 more sources

Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors

Journal of Pharmacology and Experimental Therapeutics, 2019
In an integrative approach, we studied the role of histamine H2 receptors in the mouse heart. We noted that histamine, added cumulatively to the organ bath, failed to affect the force of contraction in left atrial preparations and did not change ...
U. Gergs, G. Bernhardt, I. Buchwalow, H. Edler, J. Fröba, M. Keller, U. Kirchhefer, F. Köhler, N. Mißlinger, Hartmut Wache, J. Neumann   +10 more
semanticscholar   +1 more source

Histamine elicits glutamate release from cultured astrocytes

Journal of Pharmacological Sciences, 2018
Astrocytes play key roles in regulating brain homeostasis and neuronal activity. This is, in part, accomplished by the ability of neurotransmitters in the synaptic cleft to bind astrocyte membrane receptors, activating signalling cascades that regulate ...
Anikó Kárpáti, Takeo Yoshikawa, Tadaho Nakamura, Tomomitsu Iida, Takuro Matsuzawa, Haruna Kitano, Ryuichi Harada, Kazuhiko Yanai   +7 more
doaj   +1 more source

Recent Advances in Molecular Pharmacology of the Histamine Systems: Roles of C-terminal Tails of Histamine Receptors

Journal of Pharmacological Sciences, 2006
.: G-protein-coupled receptors (GPCR) represent a large and diverse superfamily of integral membrane proteins to which histamine receptors belong. Increasing numbers of proteins have been identified to interact with the C-termini of GPCRs.
Kuramasu Atsuo, Sukegawa Jun, Yanagisawa Teruyuki, Yanai Kazuhiko   +3 more
doaj   +1 more source

Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2–/– mice and human cholangiocarcinoma tumorigenesis

Hepatology, 2018
Primary sclerosing cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that (1) histamine increases biliary hyperplasia through H1/H2 histamine receptors (HRs) and (2) histamine levels increase and mast cells (MCs)
Lindsey Kennedy, Laura A Hargrove, Jennifer Demieville, W. Karstens, Hannah Jones, S. DeMorrow, F. Meng, P. Invernizzi, F. Bernuzzi, G. Alpini, Steven A. Smith, Austin Akers, Vik Meadows, H. Francis   +13 more
semanticscholar   +1 more source

On the Mechanisms Underlying Histamine Induction of Gastric Mucosal Lesions in Rats With Partial Gastric Vascular Occlusion

Journal of Pharmacological Sciences, 2003
Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed
Kikuko Amagase, Susumu Okabe
doaj   +1 more source

Histamine modulation of urinary bladder urothelium, lamina propria and detrusor contractile activity via H1 and H2 receptors

Scientific Reports, 2019
The mechanisms underlying bladder contractile disorders such as overactive bladder are not fully understood, and there is limited understanding of the receptor systems modulating spontaneous bladder contractions.
Zane Stromberga, R. Chess-Williams, Christian Moro   +2 more
semanticscholar   +1 more source

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice. [PDF]

CNS Neurosci Ther
Pitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Zhao Y, Fu Y, Liu T, Yang Z, Yang Z, Chen B, Zhou L, Yang J, Chen D, Han X, Tang Y, Ye JH, Miao CY, Fu R.   +13 more
europepmc   +2 more sources

The Histamine H4 Receptor: From Orphan to the Clinic

Frontiers in Pharmacology, 2015
The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus ...
Robin L. Thurmond
doaj   +1 more source

Histamine and migraine revisited: mechanisms and possible drug targets

The Journal of Headache and Pain, 2019
Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm, Katrine Falkenberg, Jes Olesen   +2 more
doaj   +1 more source