Results 51 to 60 of about 19,126 (227)

Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy

Life
Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders.
Erwen Kou, Xiaobei Zhang, Baiping Dong, Bo Wang, Yuanjie Zhu   +4 more
doaj   +1 more source

Role of the Histaminergic System in the Inhibitory Effect of Melatonin on Broiler Chicken Feed Intake [PDF]

Poultry Science Journal
Prior investigations have postulated that melatonin, a prominent hormone produced by the pineal gland, can reduce animal food consumption. This study was designed to evaluate the involvement of central histamine H1 and H2 receptors in regulating ...
Majid Taati, Hassan Norouzian, Vahid Farhadi   +2 more
doaj   +1 more source

NF-kB overexpression and decreased immunoexpression of AR in the muscular layer is related to structural damages and apoptosis in cimetidine-treated rat vas deferens [PDF]

, 2013
Background: Cimetidine, histamine H-2 receptors antagonist, has caused adverse effects on the male hormones and reproductive tract due to its antiandrogenic effect.
Beltrame, Flavia L., Caneguim, Breno H., Cerri, Paulo S., Koshimizu, Juliana Y., Pizzol, Jose P. de, Sasso-Cerri, Estela   +5 more
core   +3 more sources

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, EarlyView.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadary, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source

Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam. [PDF]

PLoS ONE, 2011
Many commonly used non-steroidal anti-inflammatory drugs (NSAIDs) also cause gastrointestinal toxicity, including the development of life-threatening peptic ulcers. We report that mast cell-deficient mice have an extremely high incidence of severe peptic
Daniel D Hampton, Laura P Hale
doaj   +1 more source

Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice

Journal of Pharmacological Sciences, 2022
Histamine is a major neurotransmitter and alleviates neuronal damage after ischemic injury via H2 receptors. Herein, we investigated the effects of H2 receptor agonists on the blood-brain barrier (BBB) disruption after traumatic brain injury (TBI).
Shotaro Michinaga, Kiyomi Sonoda, Naoki Inazuki, Manae Ezaki, Hiroki Awane, Kahori Shimizu, Shigeru Hishinuma, Hiroyuki Mizuguchi   +7 more
doaj   +1 more source

Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice. [PDF]

, 2016
Published onlineJournal ArticleThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.The recently described 'gasomediator' hydrogen sulfide (H2S) has been involved in pain mechanisms, but its ...
Cerqueira, AR, Costa, SK, De Nucci, G, Ekundi-Valentim, E, Florenzano, J, Muscará, MN, Ribela, MT, Rodrigues, L, Santos, KT, Schmidt, TP, Soares, AG, Teixeira, SA, Whiteman, M, Wood, M   +13 more
core   +1 more source

Hydrochlorides, hydrates, hydronitrate, and an unanticipated hydrolysis product of famotidine

Acta Crystallographica Section C, EarlyView.
The structures of a new polymorph of famotidine hydrochloride, a famotidine hydrochloride hydrate, a new hydronitrate salt of famotidine, and an unexpected hydrolyzed complex of famotidine are reported. The famotidine hydrochloride hydrate and the hydrolyzed famotidine hydrochloride have Z′ values of 2 and 4, respectively.This article contributes to ...
MacKenzie C. Weaver, Allen G. Oliver, Toni L. O. Barstis   +2 more
wiley   +1 more source

Enhanced histamine H2 excitation of striatal cholinergic interneurons in l-DOPA-induced dyskinesia

Neurobiology of Disease, 2015
Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of l-DOPA-induced dyskinesia (LID).
Sean Austin O. Lim, Rong Xia, Yunmin Ding, Lisa Won, William J. Ray, Stephen A. Hitchcock, Daniel S. McGehee, Un Jung Kang   +7 more
doaj   +1 more source

Signal transduction mechanism of biased ligands at histamine H2 receptors [PDF]

, 2014
7TMRs (seven-transmembrane receptors) exist as conformational collections in which different conformations would lead to differential downstream behaviours such as receptor phosphorylation, G-protein activation and receptor internalization.
Alonso, Natalia, Davio, Carlos Alberto, Echeverría, Emiliana Beatriz, Fernández, Natalia Brenda, Monczor, Federico, Shayo, Carina Claudia   +5 more
core   +1 more source