Results 71 to 80 of about 19,126 (227)
Reproductive, Female and Child Health, Volume 5, Issue 2, June 2026.ABSTRACT Objective Interstitial cystitis/bladder pain syndrome (IC/BPS) is linked to bladder and/or pelvic pain, pressure, and discomfort with urinary frequency. Despite guidelines, there is a need for better treatment options. This study analyzed patient demographics, clinical characteristics, and treatment patterns for medications and procedures in ...
Jaromir Mikl +8 more
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, Volume 600, Issue 8, Page 1137-1150, April 2026.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Repurposing drugs in oncology (ReDO)—cimetidine as an anti-cancer agent [PDF]
, 2015 Cimetidine, the first H2 receptor antagonist in widespread clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical and clinical studies for a number of different cancer types.
Bouche, Gauthier +4 more
core +1 more source
Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond
Advanced Science, Volume 13, Issue 23, 23 April 2026.Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi +4 more
wiley +1 more source
Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1
MicrobiologyOpen, 2019 The histamine H2 receptor (H2R) is a G protein‐coupled receptor that mediates cyclic AMP production, protein kinase A activation, and MAP kinase signaling.
Robert Fultz +9 more
doaj +1 more source
DEN Open, Volume 6, Issue 1, April 2026.ABSTRACT Gastric hyperplastic polyps can cause gastrointestinal bleeding, and their enlargement has been associated with long‐term acid‐suppressive therapy. Vonoprazan (VPZ), a potassium‐competitive acid blocker, provides potent acid suppression and may induce hypergastrinemia, potentially contributing to the growth of hyperplastic polyps.
Kengo Kasuga +9 more
wiley +1 more source
Allergic manifestations and cutaneous histamine responses in patients with McCune Albright syndrome
World Allergy Organization Journal, 2013 Background McCune Albright syndrome (MAS) is a rare disorder characterized by precocious puberty, café-au-lait spots, and fibrous dysplasia. Its cause is an activating mutation in the GNAS gene, encoding a subunit of the stimulatory G protein, Gsalpha ...
Jill D Jacobson +2 more
doaj +1 more source
Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]
, 2017 Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E. +4 more
core +2 more sources
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aim Stress‐related mucosal bleeding among critically ill patients in intensive care unit (ICU) contributes substantially to morbidity and mortality. Despite growing concerns globally over inappropriate stress ulcer prophylaxis (SUP) use, limited data exist from Ethiopia, particularly in ICU settings.
Samuel Agegnew Wondm +11 more
wiley +1 more source
Frontiers in Immunology, 2017 Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease where activated glia release pro-inflammatory cytokines that trigger a vicious cycle of neurodegeneration in the absence of resolution of inflammation.
Savina Apolloni +11 more
doaj +1 more source