Results 131 to 140 of about 36,316 (246)

Protective Role for Itaconate During Inhaled Allergen Challenge

Allergy, EarlyView.
Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers, Patricia P. Ogger, Christina Michalaki, Helen Stölting, Simone A. Walker, Anna Caldwell, John M. Halket, Kathryn Duvall, Atia Batool, Lisha Joshi, Helen O'Brien, Cormac McCarthy, Timothy Hinks, Gail M. Gauvreau, Paul M. O'Byrne, Clare M. Lloyd, Adam J. Byrne   +16 more
wiley   +1 more source

Chronic Urticaria and Malignancy: A Review Uncovering the Common Links. [PDF]

Biomedicines
Lekli E, Hoxha M, Bova M, Gjonbrataj J, Mati K, Vyshka G, Qirko E.   +6 more
europepmc   +1 more source

Peanut Component‐Specific IgE and IgG4 Are Modulated by Sublingual Immunotherapy and Are Associated With Remission in 1–4‐Year‐Old Children

Allergy, EarlyView.
This study presents a post hoc analysis of longitudinal changes in peanut component‐specific IgE and IgG4 in children aged 1–4 years undergoing peanut SLIT, aiming to uncover immune mechanisms and potential biomarkers of remission. Peanut SLIT reduced IgE and increased IgG4 responses to Ara h 1, Ara h 2, Ara h 3, and Ara h 6.
Neel Singh, Janelle Kesselring, Jess Humphrey, Lauren Herlihy, A. Wesley Burks, Johanna Smeekens, Corinne Keet, J. Andrew Bird, Edwin H. Kim, Michael Kulis   +9 more
wiley   +1 more source

Exacerbations and Management of Asthma in Viral Lower Respiratory Tract Infections: The Significance of Immunoglobulin E. [PDF]

Immun Inflamm Dis
Akhavan M, Yousefi P, Tabibzadeh A.
europepmc   +1 more source

Thaumatin‐Like Proteins in Molecular Allergy Diagnostics: Uncommon, Co‐Sensitized, and Clinically Inconspicuous? Insights From an Italian Cohort

Allergy, EarlyView.
This study assessed the prevalence, quantitative IgE levels, co‐sensitization patterns, and clinical significance of IgE reactivity to two TLPs—Act d 2 (kiwi) and Mal d 2 (apple)—in a large Italian allergic cohort. Thaumatin‐like protein (TLP) sensitization was uncommon (1.9%) and usually clinically silent when isolated.
Enrico Scala, Damiano Abeni, Mauro Giani, Valeria Villella, Elisabetta Caprini, Ignazio Brusca, Lorenzo Cecchi, Danilo Villalta, Riccardo Asero   +8 more
wiley   +1 more source

IgE Nonresponders in Basophil Activation Tests: A Narrative Review From Mechanistic Insights to Clinical Implications and Future Directions. [PDF]

J Immunol Res
Eberlein B, Biedermann T.
europepmc   +1 more source

The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation

Allergy, EarlyView.
Farm dust extract (FDE) treatment reduces airway eosinophilia, mucus overproduction, and MHC‐II expression on DCs, limiting antigen presentation and Th2 inflammation. It increases PD‐L1 on DCs, promoting T cell deactivation. Additionally, FDE enhances Tregs and upregulates CTLA‐4, reinforcing suppression.
Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertüz, Christoph Müller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Önder Yildirim, Erika von Mutius   +16 more
wiley   +1 more source

A Review of Acupuncture for Allergic Disorders: Modulation of Mast Cell Regulation via Inflammatory Pathway Suppression and Cytokine Balance. [PDF]

Int J Gen Med
Li Y, Meng Y, Chen C, Jiang K, Li J.
europepmc   +1 more source

Molecular IgE Reactivity Profiling With Micro‐Arrayed Allergens Reveals Distinct Interregional Patterns of Sensitization and a Hypoallergenic Region in Türkiye

Allergy, EarlyView.
A prospective, systematic and cross‐sectional population study was performed involving 1000 adult subjects from five centers representing different climatic areas of Türkiye (Turkey). Molecular IgE profiling demonstrated substantial interregional variation and identified a hypoallergenic region in the easternmost area with a continental climate.
Alp Kazancioglu, Huey‐Jy Huang, Sengul Aksakal, Ismet Bulut, Maria‐Roxana Buzan, Kuan‐Wei Chen, Monica Daniela Cotarcă, Alexandra Dubovets, Pia Gattinger, Okan Gulbahar, Ali Fuat Kalyoncu, Alexander Karaulov, Evgenii Kozlov, Carmen Panaitescu, Thomas Schlederer, Daria Trifonova, Mikhail Tulaev, Murat Turk, Susanne Vrtala, Milena Weber, Lauriana‐Eunice Zbîrcea, Bulent Enis Sekerel, Rudolf Valenta   +22 more
wiley   +1 more source

Transcriptome-Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass-Specific Phenotypes. [PDF]

Eur J Immunol
Koers J, Hoogendijk AJ, Tol S, Van Alphen FPJ, Derksen NIL, van den Biggelaar M, Rispens T.   +6 more
europepmc   +1 more source