Results 171 to 180 of about 637,770 (292)

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy. [PDF]

Allergy
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Tharakan A, Qu X, Camarena C, Abaidoo-Myles A, Naik P, Allegood J, Kumar A, Pokhriyal M, Lownik JC, Zellner MP, Way GW, Liu J, Cowart LA, Eisenbarth SC, Landry JW, Conrad DH, Martin RK.   +16 more
europepmc   +2 more sources

Autosomal Dominant Hyper‐IgE Syndrome Patients Retain IL10‐Producing preTh17‐Cells That Are Activated by Opportunistic Pathogens and Support IgE Production

Allergy, EarlyView.
IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti, Chiara Vasco, Francesca Clemente, Paola Larghi, Sara Maioli, Edoardo Scarpa, Elena Carelli, Nadia Pulvirenti, Maria Lucia Sarnicola, Mariacristina Crosti, Manal Bel Imam, Willem van de Veen, Loris Rizzello, Sergio Abrignani, Lucia A. Baselli, Rosa Maria Dellepiane, Maria Carrabba, Giovanna Fabio, Jens Geginat   +18 more
wiley   +1 more source

Immune-inflammatory endotypes of chronic rhinosinusitis: from epithelial alarmins to personalized therapy. [PDF]

Front Immunol
Li H, Wang L, Li D.
europepmc   +1 more source

Exhaled Volatile Organic Compounds Identify Allergic Patients Among Individuals With Chronic Rhinitis

Allergy, EarlyView.
Exhaled decane and nonadecane discriminate allergic (AR + LAR) from non‐allergic (NAR + HC) subjects among individuals with chronic rhinitis. LAR patients display higher levels of exhaled nonadecane than NAR individuals at baseline. Subjects with FeNO≥ 25 ppb have higher levels of exhaled decane, nonanal, and styrene than individuals with FeNO < 25 ppb
Rosa Alba Sola‐Martinez, Laura Zubiaga‐Fernandez, Marta Figuerola, Anyith Cruz‐Amaya, Carlos J. Aranda, Maria J. Torres, Ibon Eguiluz‐Gracia, Carmen Rondon, Teresa De Diego Puente, Almudena Testera‐Montes   +9 more
wiley   +1 more source

Atopic dermatitis: pathogenesis, immunology, microbiome, and salivary biomarkers. [PDF]

Front Immunol
Abraityte S, Tamasauskiene L, Gasiuniene E, Jankauskaite L.   +3 more
europepmc   +1 more source

The Evolution of Sesame Seed Allergy Over Time

Allergy, EarlyView.
This study analyzes the natural history of sesame over time and the changes in biomarkers between sesame allergic and sesame sensitised but tolerant children. The period prevalence of sesame allergy increased from 0.5% between 12 and 36 m to 1.5% between 7 and 12 y children in the EAT‐On study with 10 children developing new sesame allergy. Sesame‐sIgE
Ru‐Xin Foong, George Du Toit, Henry T. Bahnson, Ronald van Ree, Suzana Radulovic, Serge A. Versteeg, Joanna Craven, Matthew Kwok, Zainab Jama, Helen A. Brough, Kirsty Logan, Michael R. Perkin, Carsten Flohr, Alexandra F. Santos, Gideon Lack   +14 more
wiley   +1 more source

Chronic spontaneous cholinergic urticaria: advances in immunological mechanisms focusing on neuro-immune crosstalk and novel targeted therapeutic strategies. [PDF]

Front Immunol
Yang M, Lin S, Lu Y, Jin H, Zhang X, Chen Z.   +5 more
europepmc   +1 more source

Frequency and Severity of Allergic Reactions to Non‐Mandatory Labelled Allergenic Foods—Data From Two Large European Cohorts

Allergy, EarlyView.
In two large European cohorts, 589 reactions to non‐mandatory labelled plant‐based foods were identified with sunflower seed, pine nut, pea and lentil as the most frequent triggers. Reaction severity was not different between mandatory and non‐mandatory labelled allergenic foods. Their frequency and rising trends (e.g., fenugreek, pumpkin seed) support
Sabine Dölle‐Bierke, Alejandro Gonzalo‐Fernández, Dominique Sabouraud‐Leclerc, Laura Barreales‐Tolosa, Barbara Ballmer‐Weber, Simona Belohlavkova, Maria B. Bilò, Ruta Dubakiene, Karin Hartmann, Monika Jedrzejczak‐Czechowicz, Thuy‐My Le, Lars Lange, Nikolaos G. Papadopoulos, Guillaume Pouessel, Isabel Reig, Athanasios Sinaniotis, E. N. Clare Mills, Margitta Worm, Montserrat Fernández‐Rivas   +18 more
wiley   +1 more source

An interdisciplinary framework for management of ocular allergy: Integrating the allergist in clinical practice. [PDF]

Indian J Ophthalmol
Gupta N, Mahalingam S, Goel T.
europepmc   +1 more source

Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test

Allergy, EarlyView.
The basophil activation test (using the activation marker CD203c) was the only test able to both exclude and confirm sesame seed allergy with precision. A negative skin prick test to sesame extract or tahini and undetectable IgE to Ses i 1 could not rule out sesame seed allergy.
Ru‐Xin Foong, Irene Bartha, Holly Boyd, Andreina Marques‐Mejias, Suzana Radulovic, Marta Krawiec, Faye Harrison, Malak Eghleilib, Grammatiki Antoneria, Zainab Jama, Matthew Kwok, Vasco Claro, Cristian Ricci, Tom Marrs, Gideon Lack, George Du Toit, Alexandra F. Santos   +16 more
wiley   +1 more source