Results 11 to 20 of about 36,316 (246)
A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. [PDF]
PLoS ONE, 2011 Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic understanding of allergic responses. We here characterize a novel soluble version of the IgE-binding alpha-chain of Fc-epsilon-RI
Eleonora Dehlink +9 more
doaj +1 more source
IgE Antibodies: From Structure to Function and Clinical Translation
Antibodies, 2019 Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic reactions, and their powerful effector functions activated through binding to Fc receptors FcεRI and FcεRII/CD23. Structural studies of IgE-Fc alone, and when
Brian J. Sutton +3 more
doaj +1 more source
The other side of the coin: IgE deficiency, a susceptibility factor for malignancy occurrence
World Allergy Organization Journal, 2021 Since the discovery of IgE, almost all attention was given to conditions with elevated specific or total IgE levels such as atopy, type I hypersensitivity reactions, or parasitic infestations. Recent prospective and retrospective studies show that having
Denisa Ferastraoaru +2 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 1997 The dual function of eosinophils has been evidenced in protective immunity against parasites as well as in pathological manifestations during allergic disorders.
Sophie Nutten +5 more
doaj +1 more source
Frontiers in Immunology, 2022 Background10% of US residents have food allergies, including 2% with peanut allergy. Mast cell mediators released during the allergy effector phase drive allergic reactions.
Jada Suber +11 more
doaj +1 more source
IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action
Annual Review of Immunology, 2023 The evolution of IgE in mammals added an extra layer of immune protection at body surfaces to provide a rapid and local response against antigens from the environment. The IgE immune response employs potent expulsive and inflammatory forces against local antigen provocation, at the risk of damaging host tissues and causing allergic disease.
McDonnell, James +3 more
openaire +4 more sources
Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells
Cells, 2021 Mast cells (MCs) act as primary effectors in inflammatory and allergic reactions by releasing intracellularly-stored inflammatory mediators in diseases.
Hiroyuki Ogasawara, Masato Noguchi
doaj +1 more source
The B Cell Response and Formation of Allergenic and Anti-Allergenic Antibodies in Food Allergy
Biology, 2023 Food allergies are a growing public health concern worldwide, especially in children and young adults. Allergen-specific IgE plays a central role in the pathogenesis of food allergies, but their titers poorly correlate with allergy development.
Christopher C. Udoye +2 more
doaj +1 more source
AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice
World Allergy Organization Journal, 2019 Background: Atopics have a lower risk for malignancies, and IgE targeted to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or adaptive immune surveillance can confer protection against tumors remains unclear.
Josef Singer +6 more
doaj +1 more source
Frontiers in Immunology, 2018 IgE is the key mediator of allergic responses. Omalizumab, an IgE-specific monoclonal antibody that depletes IgE, is effective for treating severe allergic asthma.
Dana E. Ward +4 more
doaj +1 more source