Results 21 to 30 of about 637,770 (292)

The structure of human CD23 and its interactions with IgE and CD21 [PDF]

, 2005
The low-affinity immunoglobulin E ( IgE) receptor, CD23 ( Fc epsilon RII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response.
Grundy, GJ, Hibbert, R G, Peter Teriete, Jonathan P. Hannan, Brian J. Sutton, Rajko Reljić, Gould, H J, Rebecca L. Beavil, Holers, V M, Hannah J. Gould, Holers, VM, Richard G. Hibbert, McDonnell, JM, Gabrielle J. Grundy, Hibbert, RG, Sutton, BJ, James M. McDonnell, Reljic, R, V. Michael Holers, Grundy, G J, Gould, HJ, Hannan, JP, Beavil, R L, Sutton, B J, Teriete, P, Beavil, RL, McDonnell, J M; id_orcid, Hannan, J P   +27 more
core   +1 more source

AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice

World Allergy Organization Journal, 2019
Background: Atopics have a lower risk for malignancies, and IgE targeted to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or adaptive immune surveillance can confer protection against tumors remains unclear.
Josef Singer, Gertrude Achatz-Straussberger, Anna Bentley-Lukschal, Judit Fazekas-Singer, Gernot Achatz, Sophia N. Karagiannis, Erika Jensen-Jarolim   +6 more
doaj   +1 more source

The B Cell Response and Formation of Allergenic and Anti-Allergenic Antibodies in Food Allergy

Biology, 2023
Food allergies are a growing public health concern worldwide, especially in children and young adults. Allergen-specific IgE plays a central role in the pathogenesis of food allergies, but their titers poorly correlate with allergy development.
Christopher C. Udoye, Marc Ehlers, Rudolf A. Manz   +2 more
doaj   +1 more source

Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta [PDF]

, 2010
IgA and IgE activity against Teladorsagia circumcincta was investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs.
Bishop, S. C., Eckersall, P.D., Bishop, S.C., Burchmore, R., Pettit, J.J., Stear, M.J., Eckersall, P. D., Pettit, J. J., Huntley, J. F., Huntley, J.F., Burchmore, R.J.S., Stear, M. J., Murphy, L.   +12 more
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Chimeric Antigen Receptors Based on Low Affinity Mutants of FcεRI Re-direct T Cell Specificity to Cells Expressing Membrane IgE

Frontiers in Immunology, 2018
IgE is the key mediator of allergic responses. Omalizumab, an IgE-specific monoclonal antibody that depletes IgE, is effective for treating severe allergic asthma.
Dana E. Ward, Brittany L. Fay, Adebomi Adejuwon, Huihui Han, Zhengyu Ma   +4 more
doaj   +1 more source

Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII

Haematologica, 2019
Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase drug levels and increase the risk of relapse.
Sanjay Rathod, Manda Ramsey, Mary V. Relling, Fred D. Finkelman, Christian A. Fernandez   +4 more
doaj   +1 more source

Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment. [PDF]

, 2008
BACKGROUND: The environmental factors that determine the elevated levels of polyclonal IgE observed in populations living in the Tropics are poorly understood but may include geohelminth infections.
Cooper Philip J, Griffin, GE, Cooper, Philip J, Chico Martha E, Vaca, MG, Alexander Neal, Chico, ME, Benitez, Susana M, Ana-Lucia Moncayo, Vaca, Maritza G, Chico, Martha E, Benitez Susana M, Moncayo, Ana-Lucia, Alexander, N, Griffin, George E, Vaca Maritza G, Maritza G Vaca, Susana M Benitez, Neal Alexander, Martha E Chico, Griffin George E, Benitez, SM, Philip J Cooper, Alexander, Neal, Moncayo, AL, George E Griffin, Moncayo Ana-Lucia, Cooper, PJ   +27 more
core   +1 more source

Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. [PDF]

PLoS ONE, 2014
Mast cells are pivotal in the pathogenesis of allergy and inflammation. In addition to the classical IgE-dependent mechanism involving crosslinking of the high-affinity receptor for IgE (FcεRI), mast cells are also activated by Toll-like receptors (TLRs)
Yangyang Yu, Kwok Ho Yip, Issan Yee San Tam, Sze Wing Sam, Chun Wai Ng, Wei Zhang, Hang Yung Alaster Lau   +6 more
doaj   +1 more source

Tracing Human IgE B Cell Antigen Receptor-Bearing Cells With a Monoclonal Anti-Human IgE Antibody That Specifically Recognizes Non-Receptor-Bound IgE

Frontiers in Immunology, 2021
Up to 30% of the population suffers from immunoglobulin E (IgE)-mediated allergies. Despite current stepwise gating approaches, the unambiguous identification of human IgE-producing cells by flow cytometry and immunohistology remains challenging. This is
Mohammed Zghaebi, Maria Byazrova, Maria Byazrova, Sabine Flicker, Sergio Villazala-Merino, Nicholas J. Campion, Victoria Stanek, Aldine Tu, Heimo Breiteneder, Alexander Filatov, Alexander Filatov, Musa Khaitov, Musa Khaitov, Verena Niederberger-Leppin, Julia Eckl-Dorna, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta   +18 more
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A Comparison of Natural and Therapeutic Anti-IgE Antibodies

Antibodies
Immunoglobulin E (IgE) plays a critical role for the immune system, fighting against parasites, toxins, and cancer. However, when it reacts to allergens without proper regulation, it can cause allergic reactions, including anaphylaxis, through a process ...
Monique Vogel, Paul Engeroff
doaj   +1 more source