Results 11 to 20 of about 637,770 (292)

Characterisation of Bovine Leukocyte Ig-like Receptors [PDF]

PLoS ONE, 2012
Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have been identified in rodents, primates, seals and chickens.
Hogan, Louise, Bhuju, Sabin, Jones, Des C, Laing, Ken, Trowsdale, John, Butcher, Philip, Singh, Mahavir, Vordermeier, Martin, Allen, Rachel L   +8 more
core   +10 more sources

IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action [PDF]

Annual Review of Immunology, 2023
The evolution of IgE in mammals added an extra layer of immune protection at body surfaces to provide a rapid and local response against antigens from the environment. The IgE immune response employs potent expulsive and inflammatory forces against local antigen provocation, at the risk of damaging host tissues and causing allergic disease.
J M, McDonnell, B, Dhaliwal, B J, Sutton, H J, Gould   +3 more
openaire   +4 more sources

A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. [PDF]

PLoS ONE, 2011
Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic understanding of allergic responses. We here characterize a novel soluble version of the IgE-binding alpha-chain of Fc-epsilon-RI
Eleonora Dehlink, Barbara Platzer, Alexandra H Baker, Jessica Larosa, Michael Pardo, Peter Dwyer, Elizabeth H Yen, Zsolt Szépfalusi, Samuel Nurko, Edda Fiebiger   +9 more
doaj   +1 more source

The other side of the coin: IgE deficiency, a susceptibility factor for malignancy occurrence

World Allergy Organization Journal, 2021
Since the discovery of IgE, almost all attention was given to conditions with elevated specific or total IgE levels such as atopy, type I hypersensitivity reactions, or parasitic infestations. Recent prospective and retrospective studies show that having
Denisa Ferastraoaru, Galateja Jordakieva, Erika Jensen-Jarolim   +2 more
doaj   +1 more source

From allergy to schistosomes: role of Fc receptors and adhesion molecules in eosinophil effector function

Memorias do Instituto Oswaldo Cruz, 1997
The dual function of eosinophils has been evidenced in protective immunity against parasites as well as in pathological manifestations during allergic disorders.
Sophie Nutten, François Trottein, Abdelillah Soussi Gounni, Jean-Paul Papin, André Capron, Monique Capron   +5 more
doaj   +1 more source

Novel peanut-specific human IgE monoclonal antibodies enable screens for inhibitors of the effector phase in food allergy

Frontiers in Immunology, 2022
Background10% of US residents have food allergies, including 2% with peanut allergy. Mast cell mediators released during the allergy effector phase drive allergic reactions.
Jada Suber, Jada Suber, Jada Suber, Yugen Zhang, Ping Ye, Rishu Guo, A. Wesley Burks, A. Wesley Burks, Michael D. Kulis, Scott A. Smith, Onyinye I. Iweala, Onyinye I. Iweala   +11 more
doaj   +1 more source

気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制 [PDF]

, 1992
Delayed cutaneous hypersensitivity towards Candida albicans was examined　in 200 patients with bronchial asthma in relation to patient age and the level of　total IgE. 1.
Tanizaki, Yosiro, Okazaki, Morihiro, Harada, Hideo, Kitani, Hikaru, Kimura, Ikuro, Ochi, Koji, Mitsunobu, Fumihiro, Mifune, Takashi   +7 more
core   +1 more source

IgE-associated enhancement of allergen presentation and T cell activation in atopic dermatitis

, 2004
Previous research has suggested that IgE-facilitated allergen presentation may play a key role in the pathogenesis of atopic dermatitis. This is the process by which allergen-specific IgE bound to Fcepsilon receptors on antigen presenting cells is able ...
Dawn. Cooper (7676549)
core   +5 more sources

Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus [PDF]

, 2008
High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial mediators of autoimmune diseases.
Wichmann, H. -Erich, Ursula Krämer, Liang Liming, Markus Ollert, Stephan Weidinger, Mempel, Martin, Bauer, Carl Peter, Baurecht Hansjörg, Prokisch Holger, Mehta Divya, von Berg, A., von Mutius, Erika, Bauer Carl Peter, Gohlke, H., Cookson, W., Depner, Martin, Wagenpfeil, S., Wichmann, H.-E., Illig, T., Michael Kabesch, Mempel, M., Novak, N., Mehta, D., Illig Thomas, Liang, L., Kabesch, Michael, von Berg Andrea, Moffatt Miriam, Prokisch, H., Heinrich Joachim, Herbarth, Olf, Gohlke Henning, Bieber, Thomas, Olf Herbarth, Martin Depner, Stefan Wagenpfeil, Heinrich, Joachim, H-Erich Wichmann, Erika von Mutius, Heinrich, J., Gieger, Christian, Heidrun Behrendt, Ollert Markus, Thomas Bieber, Meitinger, T., Divya Mehta, Ring, Johannes, Rodriguez Elke, Herbarth Olf, Miriam Moffatt, Natalija Novak, von Mutius Erika, Cookson William, Mehta, Divya, Behrendt Heidrun, Klopp, Norman, Ring Johannes, Bieber Thomas, Cookson, William, Sibylle Koletzko, Meitinger Thomas, Wichmann, Heinz-Erich, Mempel Martin, Hansjörg Baurecht, William Cookson, Kraemer, Ursula, Gieger, C., Gohlke, Henning, Christian Gieger, Baurecht, H., Depner Martin, Kabesch Michael, Weidinger, S., Bieber, T., Herbarth, O., Novak, Natalija, Berdel Dietrich, Moffatt, M., Berdel, D., von Mutius, E., Koletzko, Sibylle, Klopp, N., Krämer Ursula, Gieger Christian, Liang, Liming, Bauer, C.P., Johannes Ring, Berdel, Dietrich, Wagenpfeil, Stefan, Mutius, Erika von, Koletzko Sibylle, Koletzko, S., Rodriguez, E., Krämer, U., Ollert, Markus, Ollert, M., Rodriguez, Elke, Wichmann H.-Erich, Kabesch, M., Behrendt, H., Prokisch, Holger, Moffatt, Miriam, Henning Gohlke, Carl Peter Bauer, Illig, Thomas, Meitinger, Thomas, Liming Liang, Joachim Heinrich, Andrea von Berg, Thomas Illig, Novak Natalija, von Berg, Andrea, Weidinger, Stephan, Weidinger Stephan, Klopp Norman, Baurecht, Hansjoerg, Behrendt, Heidrun, Thomas Meitinger, Depner, M., Berg, Andrea von, Dietrich Berdel, Ring, J., Wagenpfeil Stefan, Elke Rodriguez, Norman Klopp, Martin Mempel, Holger Prokisch, Weidinger, S;Gieger, C;Rodriguez, E;Baurecht, H;Mempel, M;Klopp, N;Gohlke, H;Wagenpfeil, S;Ollert, M;Ring, J;Behrendt, H;Heinrich, J;Novak, N;Bieber, T;Kramer, U;Berdel, D;von Berg, A;Bauer, CP;Herbarth, O;Koletzko, S;Prokisch, H;Mehta, D;Meitinger, T;Depner, M;von Mutius, E;Liang, L;Moffatt, M;Cookson, W;Kabesch, M;Wichmann, HE;Illig, T   +127 more
core   +1 more source

Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells

Cells, 2021
Mast cells (MCs) act as primary effectors in inflammatory and allergic reactions by releasing intracellularly-stored inflammatory mediators in diseases.
Hiroyuki Ogasawara, Masato Noguchi
doaj   +1 more source