Results 11 to 20 of about 75,053 (306)
γδ T cells affect IL-4 production and B-cell tolerance [PDF]
, 2014 γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun +22 more
core +1 more source
IgE Antibodies: From Structure to Function and Clinical Translation
Antibodies, 2019 Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic reactions, and their powerful effector functions activated through binding to Fc receptors FcεRI and FcεRII/CD23. Structural studies of IgE-Fc alone, and when
Brian J. Sutton +3 more
doaj +1 more source
A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. [PDF]
PLoS ONE, 2011 Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic understanding of allergic responses. We here characterize a novel soluble version of the IgE-binding alpha-chain of Fc-epsilon-RI
Eleonora Dehlink +9 more
doaj +1 more source
The other side of the coin: IgE deficiency, a susceptibility factor for malignancy occurrence
World Allergy Organization Journal, 2021 Since the discovery of IgE, almost all attention was given to conditions with elevated specific or total IgE levels such as atopy, type I hypersensitivity reactions, or parasitic infestations. Recent prospective and retrospective studies show that having
Denisa Ferastraoaru +2 more
doaj +1 more source
気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制 [PDF]
, 1992 Delayed cutaneous hypersensitivity towards Candida albicans was examined in 200 patients with bronchial asthma in relation to patient age and the level of total IgE. 1.
Harada, Hideo +7 more
core +1 more source
Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells [PDF]
, 2018 The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the
Ambrosio, Laura Fernanda +7 more
core +1 more source
Memorias do Instituto Oswaldo Cruz, 1997 The dual function of eosinophils has been evidenced in protective immunity against parasites as well as in pathological manifestations during allergic disorders.
Sophie Nutten +5 more
doaj +1 more source
Frontiers in Immunology, 2022 Background10% of US residents have food allergies, including 2% with peanut allergy. Mast cell mediators released during the allergy effector phase drive allergic reactions.
Jada Suber +11 more
doaj +1 more source
Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice [PDF]
, 2016 Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
De Beuckelaer, Ans +10 more
core +1 more source
IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action
Annual Review of Immunology, 2023 The evolution of IgE in mammals added an extra layer of immune protection at body surfaces to provide a rapid and local response against antigens from the environment. The IgE immune response employs potent expulsive and inflammatory forces against local antigen provocation, at the risk of damaging host tissues and causing allergic disease.
McDonnell, James +3 more
openaire +4 more sources