Results 31 to 40 of about 637,770 (292)
Review: Omalizumab in the treatment of severe asthma: efficacy and current problems
Therapeutic Advances in Respiratory Disease, 2008 Omalizumab is a humanized monoclonal anti-IgE antibody recently approved for the treatment of severe allergic asthma. This drug inhibits allergic responses by binding to serum IgE, thus preventing their interactions with cellular IgE receptors ...
Girolamo Pelaia +4 more
doaj +1 more source
IgE Trimers Drive SPE-7 Cytokinergic Activity
Scientific Reports, 2017 Degranulation of mast cells and basophils, with release of agents of the allergic response, ensues when multivalent antigens bind to and cross-link the cells’ receptor-bound IgE antibodies. A widely used commercial monoclonal IgE antibody, SPE-7 IgE from
Heather J. Bax +10 more
doaj +1 more source
FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment. [PDF]
PLoS ONE, 2012 BACKGROUND: Mast cell-derived mediators mediate several of the pathological features of asthma. Microbial infections induce asthma exacerbations in which the contribution of mast cells remains incomprehensible.
Rohit Saluja +3 more
doaj +1 more source
Anti-Ids in Allergy: Timeliness of a Classic Concept
World Allergy Organization Journal, 2010 Anti-idiotypic antibodies (anti-ids) are part of natural immune responses with regulatory capacity. Their effect on an antigen-specific, so-called Ab1 antibody response, is dependent on 1) the original antigen, which they mirror, being Ab2 antibodies ...
Julia Wallmann, MSc +2 more
doaj +1 more source
Pediatric usage of Omalizumab: A promising one
World Allergy Organization Journal, 2021 Allergic and related diseases have a substantial epidemiological impact on the pediatric population. Small molecule-based medicines have been traditionally used to manage the diseases.
Lin Yu, MD +3 more
doaj +1 more source
Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery
Advanced Functional Materials, EarlyView.A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon +5 more
wiley +1 more source
Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity FcεRI receptor [PDF]
, 2011 Allergy is a serious life altering disease that is increasingly affecting people in the industrialized countries. Allergic manifestations are not restricted to humans, but are also observed, example, in inbred dogs and horses.
Sabban, Sari
core +6 more sources
Frontiers in Immunology, 2012 Classically, allergy depends on IgE antibodies and on high-affinity IgE receptors expressed by mast cells and basophils. This long accepted IgE/FcεRI/mast cell paradigm, on which the definition of immediate hypersensitivity was based in the Gell and ...
Friederike eJönsson, Marc eDaëron
doaj +1 more source
Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source
IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis
Advanced Science, EarlyView.The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui +12 more
wiley +1 more source