Results 31 to 40 of about 37,159 (265)

Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII

Haematologica, 2019
Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase drug levels and increase the risk of relapse.
Sanjay Rathod, Manda Ramsey, Mary V. Relling, Fred D. Finkelman, Christian A. Fernandez   +4 more
doaj   +1 more source

Tracing Human IgE B Cell Antigen Receptor-Bearing Cells With a Monoclonal Anti-Human IgE Antibody That Specifically Recognizes Non-Receptor-Bound IgE

Frontiers in Immunology, 2021
Up to 30% of the population suffers from immunoglobulin E (IgE)-mediated allergies. Despite current stepwise gating approaches, the unambiguous identification of human IgE-producing cells by flow cytometry and immunohistology remains challenging. This is
Mohammed Zghaebi, Maria Byazrova, Maria Byazrova, Sabine Flicker, Sergio Villazala-Merino, Nicholas J. Campion, Victoria Stanek, Aldine Tu, Heimo Breiteneder, Alexander Filatov, Alexander Filatov, Musa Khaitov, Musa Khaitov, Verena Niederberger-Leppin, Julia Eckl-Dorna, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta   +18 more
doaj   +1 more source

Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. [PDF]

PLoS ONE, 2014
Mast cells are pivotal in the pathogenesis of allergy and inflammation. In addition to the classical IgE-dependent mechanism involving crosslinking of the high-affinity receptor for IgE (FcεRI), mast cells are also activated by Toll-like receptors (TLRs)
Yangyang Yu, Kwok Ho Yip, Issan Yee San Tam, Sze Wing Sam, Chun Wai Ng, Wei Zhang, Hang Yung Alaster Lau   +6 more
doaj   +1 more source

A Comparison of Natural and Therapeutic Anti-IgE Antibodies

Antibodies
Immunoglobulin E (IgE) plays a critical role for the immune system, fighting against parasites, toxins, and cancer. However, when it reacts to allergens without proper regulation, it can cause allergic reactions, including anaphylaxis, through a process ...
Monique Vogel, Paul Engeroff
doaj   +1 more source

Review: Omalizumab in the treatment of severe asthma: efficacy and current problems

Therapeutic Advances in Respiratory Disease, 2008
Omalizumab is a humanized monoclonal anti-IgE antibody recently approved for the treatment of severe allergic asthma. This drug inhibits allergic responses by binding to serum IgE, thus preventing their interactions with cellular IgE receptors ...
Girolamo Pelaia, Teresa Renda, Pasquale Romeo, Maria Teresa Busceti, Rosario Maselli   +4 more
doaj   +1 more source

IgE Trimers Drive SPE-7 Cytokinergic Activity

Scientific Reports, 2017
Degranulation of mast cells and basophils, with release of agents of the allergic response, ensues when multivalent antigens bind to and cross-link the cells’ receptor-bound IgE antibodies. A widely used commercial monoclonal IgE antibody, SPE-7 IgE from
Heather J. Bax, Holly Bowen, Rebecca L. Beavil, Raymond Chung, Malcolm Ward, Anna M. Davies, Tihomir S. Dodev, James M. McDonnell, Andrew J. Beavil, Brian J. Sutton, Hannah J. Gould   +10 more
doaj   +1 more source

FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment. [PDF]

PLoS ONE, 2012
BACKGROUND: Mast cell-derived mediators mediate several of the pathological features of asthma. Microbial infections induce asthma exacerbations in which the contribution of mast cells remains incomprehensible.
Rohit Saluja, Ingrid Delin, Gunnar P Nilsson, Mikael Adner   +3 more
doaj   +1 more source

Anti-Ids in Allergy: Timeliness of a Classic Concept

World Allergy Organization Journal, 2010
Anti-idiotypic antibodies (anti-ids) are part of natural immune responses with regulatory capacity. Their effect on an antigen-specific, so-called Ab1 antibody response, is dependent on 1) the original antigen, which they mirror, being Ab2 antibodies ...
Julia Wallmann, MSc, Isabella Pali-Schöll, PhD, Erika Jensen-Jarolim, MD   +2 more
doaj   +1 more source

Pediatric usage of Omalizumab: A promising one

World Allergy Organization Journal, 2021
Allergic and related diseases have a substantial epidemiological impact on the pediatric population. Small molecule-based medicines have been traditionally used to manage the diseases.
Lin Yu, MD, Huishan Zhang, MD, Jianwei Pan, MD, Leping Ye, MD, PhD   +3 more
doaj   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source