Results 51 to 60 of about 637,770 (292)

Clinical Longitudinal Evaluation After Regimen Stop (CLEAR) of Dupilumab in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Long‐term management strategies for severe chronic rhinosinusitis with nasal polyps (CRSwNP) increasingly include biologic therapy targeting Type 2 inflammation. However, data on outcomes after complete discontinuation of dupilumab following sustained disease control are scarce.
Patrick Huber, Manuel Lasch, Veronika Volgger, Clemens Stihl, Philipp Teupe, Fabienne Oettgen, Sophia Gantner, Moritz Gröger   +7 more
wiley   +1 more source

Futtermittel-spezifisches IgG und IgE vor und nach Eliminationsdiäten bei allergischen Hunden [PDF]

, 2012
Serum food allergen-specific antibody testing is widely offered to identify suitable ingredients for diets to diagnose adverse food reaction (AFR) in dogs with allergic skin disease.
Zimmer, Anja
core   +1 more source

Studies investigating peripheral blood derived cells that express the high affinity receptor for immunoglobulin E (Fc?RI) In Allergic Disorders

, 2008
It is just forty years since the identification of immunoglobulin E (IgE) as the reagin responsible for allergen induced immediate hypersensitivity reactions.
Sihra, Bhupinder Singh
core   +1 more source

Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels. [PDF]

, 2001
peer reviewedBACKGROUND: The ENU Mouse Mutagenesis Project aims at a large-scale, systematic production of mouse mutants using the alkylating agent ethyl-nitrosourea (ENU).
Wolf, A., Behrendt, Heidrun, Alessandrini, Francesca, Behrend, H., Ring, J., Wolf, Alexander, Ring, Johannes, Jakob, T., Hrabe de Angelis, M., Jakob, Thilo, Alessandrini, F., BALLING, Rudi, Wolf, Eckhard, Behrendt, H., Hrabé de Angelis, Martin, Wolf, E., Balling, R., Balling, Rudolf, Alessandrini, F. ; Jakob, T. ; Wolf, A. ; Wolf, E. ; Balling, R. ; Hrabé de Angelis, M. ; Ring, J. ; Behrend, H., Alessandrini, Francesca;Jakob, Thilo;Wolf, Alexander;Wolf, Eckhard;Balling, Rudolf;de Angelis, Martin Hrabe;Ring, Johannes;Behrendt, Heidrun   +19 more
core   +1 more source

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

Efficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS.
Arun Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace, Jeffrey Suh, Jivianne Lee, Marilene Wang, Sarah Wise, Naweed Chowdhury, Zachary M. Soler, Justin Turner, Timothy L. Smith, Myung Sim, Daniel M. Beswick   +13 more
wiley   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

The pharmacological mechanisms of omalizumab in patients with very high IgE levels—Clues from studies on atopic dermatitis

Dermatologica Sinica, 2012
Seventeen case series investigating the effects of omalizumab on patients with atopic dermatitis included patients whose pretreatment serum IgE was above 700 IU/ml, the upper inclusion limit specified in the product label.
Tse Wen Chang, Jiun-Bo Chen, Chia-Yu Chu
doaj   +1 more source

IgE and high‐affinity IgE receptor in chronic inducible urticaria, pathogenic, and management relevance

Clinical and Translational Allergy, 2022
Background IgE and high‐affinity IgE receptor (FcεRI) expression on basophils have been scarcely explored in patients with chronic inducible urticaria (CIndU).
Ana M. Giménez‐Arnau, Clara Ribas‐Llauradó, Nasser Mohammad‐Porras, Gustavo Deza, Ramón M. Pujol, Ramón Gimeno   +5 more
doaj   +1 more source

Temporal Changes in Total Serum Immunoglobulin E Levels in East German Children and the Effect of Potential Predictors [PDF]

, 2012
Background: Elevated total serum immunoglobulin E (IgE) levels are a prominent feature of allergic and parasitic diseases. An epidemiologic study was conducted in East German children to describe trends in the development of total serum IgE levels and ...
Wichmann, Heinz-Erich, Rzehak, Peter, Heinrich, Joachim, Wichmann, H.-E., Thiering, Elisabeth, Thiering, E., Brüske, Irene, Rzehak, P., Flohrs, K., Flohrs, Katrin, Heinrich, J., Brüske, I.   +11 more
core   +1 more source