Results 21 to 30 of about 36,316 (246)

Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII

Haematologica, 2019
Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase drug levels and increase the risk of relapse.
Sanjay Rathod, Manda Ramsey, Mary V. Relling, Fred D. Finkelman, Christian A. Fernandez   +4 more
doaj   +1 more source

Tracing Human IgE B Cell Antigen Receptor-Bearing Cells With a Monoclonal Anti-Human IgE Antibody That Specifically Recognizes Non-Receptor-Bound IgE

Frontiers in Immunology, 2021
Up to 30% of the population suffers from immunoglobulin E (IgE)-mediated allergies. Despite current stepwise gating approaches, the unambiguous identification of human IgE-producing cells by flow cytometry and immunohistology remains challenging. This is
Mohammed Zghaebi, Maria Byazrova, Maria Byazrova, Sabine Flicker, Sergio Villazala-Merino, Nicholas J. Campion, Victoria Stanek, Aldine Tu, Heimo Breiteneder, Alexander Filatov, Alexander Filatov, Musa Khaitov, Musa Khaitov, Verena Niederberger-Leppin, Julia Eckl-Dorna, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta   +18 more
doaj   +1 more source

Characterisation of Bovine Leukocyte Ig-like Receptors [PDF]

PLoS ONE, 2012
Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have been identified in rodents, primates, seals and chickens.
Hogan, Louise, Bhuju, Sabin, Jones, Des C, Laing, Ken, Trowsdale, John, Butcher, Philip, Singh, Mahavir, Vordermeier, Martin, Allen, Rachel L   +8 more
openaire   +5 more sources

Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. [PDF]

PLoS ONE, 2014
Mast cells are pivotal in the pathogenesis of allergy and inflammation. In addition to the classical IgE-dependent mechanism involving crosslinking of the high-affinity receptor for IgE (FcεRI), mast cells are also activated by Toll-like receptors (TLRs)
Yangyang Yu, Kwok Ho Yip, Issan Yee San Tam, Sze Wing Sam, Chun Wai Ng, Wei Zhang, Hang Yung Alaster Lau   +6 more
doaj   +1 more source

A Comparison of Natural and Therapeutic Anti-IgE Antibodies

Antibodies
Immunoglobulin E (IgE) plays a critical role for the immune system, fighting against parasites, toxins, and cancer. However, when it reacts to allergens without proper regulation, it can cause allergic reactions, including anaphylaxis, through a process ...
Monique Vogel, Paul Engeroff
doaj   +1 more source

Review: Omalizumab in the treatment of severe asthma: efficacy and current problems

Therapeutic Advances in Respiratory Disease, 2008
Omalizumab is a humanized monoclonal anti-IgE antibody recently approved for the treatment of severe allergic asthma. This drug inhibits allergic responses by binding to serum IgE, thus preventing their interactions with cellular IgE receptors ...
Girolamo Pelaia, Teresa Renda, Pasquale Romeo, Maria Teresa Busceti, Rosario Maselli   +4 more
doaj   +1 more source

IgE Trimers Drive SPE-7 Cytokinergic Activity

Scientific Reports, 2017
Degranulation of mast cells and basophils, with release of agents of the allergic response, ensues when multivalent antigens bind to and cross-link the cells’ receptor-bound IgE antibodies. A widely used commercial monoclonal IgE antibody, SPE-7 IgE from
Heather J. Bax, Holly Bowen, Rebecca L. Beavil, Raymond Chung, Malcolm Ward, Anna M. Davies, Tihomir S. Dodev, James M. McDonnell, Andrew J. Beavil, Brian J. Sutton, Hannah J. Gould   +10 more
doaj   +1 more source

FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment. [PDF]

PLoS ONE, 2012
BACKGROUND: Mast cell-derived mediators mediate several of the pathological features of asthma. Microbial infections induce asthma exacerbations in which the contribution of mast cells remains incomprehensible.
Rohit Saluja, Ingrid Delin, Gunnar P Nilsson, Mikael Adner   +3 more
doaj   +1 more source

Mast cells & Company

Frontiers in Immunology, 2012
Classically, allergy depends on IgE antibodies and on high-affinity IgE receptors expressed by mast cells and basophils. This long accepted IgE/FcεRI/mast cell paradigm, on which the definition of immediate hypersensitivity was based in the Gell and ...
Friederike eJönsson, Marc eDaëron
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source