Results 211 to 220 of about 301,139 (266)

IgG Fc Receptors

Annual Review of Immunology, 2001
Since the description of the first mouse knockout for an IgG Fc receptor seven years ago, considerable progress has been made in defining the in vivo functions of these receptors in diverse biological systems. The role of activating FcγRs in providing a critical link between ligands and effector cells in type II and type III inflammation is now well ...
J V, Ravetch, S, Bolland
openaire   +2 more sources

IgG receptors on the mast cell

Agents and Actions, 1981
Antisera to the IgG subclasses, 1, 2a, 2b, and 2c, induced histamine release from mast cells obtained from the peritoneal washings of Lister hooded rats. The maximum responses obtained with anti-IgG1 and anti-IgG2a were as great as that for anti-IgE (more than 60% histamine release). Cells from unresponsive Wistar rats which did not secrete appreciable
I, Moodley, J L, Mongar
openaire   +2 more sources

Macrophage receptors for IgG aggregates

Experimental Cell Research, 1970
Abstract Uptake of aggregated heterologous IgG by mouse peritoneal cells in vitro was found to proceed in the absence of humoral complement, but to depend upon the C′-activating properties of the aggregates. This finding, together with results obtained in inhibition experiments using antimacrophage and anti-beta-1C sera, may indicate the existence of
M W, Hess, E F, Lüscher
openaire   +2 more sources

Platelet IgG Fc receptor

American Journal of Hematology, 1987
AbstractThe glycoprotein localization of the platelet binding site for the Fc IgG has been the subject of debate. We attempted to resolve this issue by relating the binding of radiolabeled IgG immune complexes composed of heat‐aggregated IgG to platelets from 1) healthy individuals; 2) an individual with Bernard‐Soulier syndrome lacking glycoproteins ...
J G, Kelton, J W, Smith, A V, Santos, W G, Murphy, P, Horsewood   +4 more
openaire   +2 more sources

Human IgG Fc Receptors

International Reviews of Immunology, 1997
Human IgG receptors constitute a family of glycoprotein complexes consisting of ligand-binding, and associated signaling chains. Three leukocyte classes (Fc gamma RI, II, and III) and one separate endothelial Fc gamma R class (FcRB) are defined which are expressed on hematopoietic and endothelial cells.
I A, Heijnen, J G, van de Winkel
openaire   +2 more sources

The IgG Fc receptor family

Annals of Hematology, 1998
IgG immune complexes are of central importance in the humoral immune system and strongly implicated in the pathogenesis of hematologic and rheumatic autoimmune disorders. Cross-linking of receptors for the Fc domain of IgG antibodies (FcgammaRs) triggers a wide variety of effector functions including phagocytosis, antibody-dependent cellular ...
J E, Gessner, H, Heiken, A, Tamm, R E, Schmidt   +3 more
openaire   +2 more sources

IgG Fc‐binding receptors on spermatozoa

European Journal of Immunology, 1980
AbstractThe ability of human and mouse spermatozoa to bind immunoglobulin to their surfaces was investigated by a binding assay using radioiodinated Ig. The results suggest that spermatozoa of both human and mouse origin possess Fc receptors, i.e. they have the ability to bind Fcγ region.
K K, Sethi, H, Brandis
openaire   +2 more sources

Properties of the Solubilized Placental Receptor for IgG

International Archives of Allergy and Applied Immunology, 2009
The Fc receptor activity in placental extracts prepared using EDTA and 2-mercaptoethanol was assayed using an indirect hemagglutination technique with sheep erythrocytes sensitized with rabbit IgG. The agglutinating activity of the extract was not affected by storage at ––70°C, by rapid freezing and thawing, by treatment with periodic acid ...
R, Matre, O, Tönder
openaire   +2 more sources

Heterogeneity of Human IgG Fc Receptors

ImmunoMethods, 1994
The complex family of human IgG Fc receptors show a wide cellular distribution and a strong functional heterogeneity. To date, eight different genes that are transcribed into at least 12 different mRNAs have been recognized. Although corresponding products have been identified for only some of the transcripts, in vivo at least six different Fc gamma R ...
P J, Capel, J G, van de Winkel, I E, van den Herik-Oudijk, J S, Verbeek   +3 more
openaire   +2 more sources

Inflammation in autoimmunity: receptors for IgG revisited

Trends in Immunology, 2001
During the past decade, our knowledge of Fc receptor interactions in inflammation has increased dramatically owing to the availability of single and multiple Fc-receptor-deficient mice. The deletion of activating Fc gamma receptors protects against inflammation in models of immune-complex-mediated diseases, whereas the deletion of inhibitory Fc gamma ...
H M, Dijstelbloem, J G, van de Winkel, C G, Kallenberg   +2 more
openaire   +2 more sources