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Affinity of human IgG subclasses to mouse Fc gamma receptors
MAbs, 2017 Human IgG is the main antibody class used in antibody therapies because of its efficacy and longer half-life, which are completely or partly due to Fc gamma R-mediated functions of the molecules.
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International Reviews of Immunology, 1997
Human IgG receptors constitute a family of glycoprotein complexes consisting of ligand-binding, and associated signaling chains. Three leukocyte classes (Fc gamma RI, II, and III) and one separate endothelial Fc gamma R class (FcRB) are defined which are expressed on hematopoietic and endothelial cells.
I A, Heijnen, J G, van de Winkel
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Human IgG receptors constitute a family of glycoprotein complexes consisting of ligand-binding, and associated signaling chains. Three leukocyte classes (Fc gamma RI, II, and III) and one separate endothelial Fc gamma R class (FcRB) are defined which are expressed on hematopoietic and endothelial cells.
I A, Heijnen, J G, van de Winkel
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Annals of Hematology, 1998
IgG immune complexes are of central importance in the humoral immune system and strongly implicated in the pathogenesis of hematologic and rheumatic autoimmune disorders. Cross-linking of receptors for the Fc domain of IgG antibodies (FcgammaRs) triggers a wide variety of effector functions including phagocytosis, antibody-dependent cellular ...
J E, Gessner +3 more
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IgG immune complexes are of central importance in the humoral immune system and strongly implicated in the pathogenesis of hematologic and rheumatic autoimmune disorders. Cross-linking of receptors for the Fc domain of IgG antibodies (FcgammaRs) triggers a wide variety of effector functions including phagocytosis, antibody-dependent cellular ...
J E, Gessner +3 more
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Inflammation in autoimmunity: receptors for IgG revisited
Trends in Immunology, 2001During the past decade, our knowledge of Fc receptor interactions in inflammation has increased dramatically owing to the availability of single and multiple Fc-receptor-deficient mice. The deletion of activating Fc gamma receptors protects against inflammation in models of immune-complex-mediated diseases, whereas the deletion of inhibitory Fc gamma ...
H M, Dijstelbloem +2 more
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Properties of the Solubilized Placental Receptor for IgG
International Archives of Allergy and Applied Immunology, 2009The Fc receptor activity in placental extracts prepared using EDTA and 2-mercaptoethanol was assayed using an indirect hemagglutination technique with sheep erythrocytes sensitized with rabbit IgG. The agglutinating activity of the extract was not affected by storage at ––70°C, by rapid freezing and thawing, by treatment with periodic acid ...
R, Matre, O, Tönder
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IgG Fc‐binding receptors on spermatozoa
European Journal of Immunology, 1980AbstractThe ability of human and mouse spermatozoa to bind immunoglobulin to their surfaces was investigated by a binding assay using radioiodinated Ig. The results suggest that spermatozoa of both human and mouse origin possess Fc receptors, i.e. they have the ability to bind Fcγ region.
K K, Sethi, H, Brandis
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Heterogeneity of Human IgG Fc Receptors
ImmunoMethods, 1994The complex family of human IgG Fc receptors show a wide cellular distribution and a strong functional heterogeneity. To date, eight different genes that are transcribed into at least 12 different mRNAs have been recognized. Although corresponding products have been identified for only some of the transcripts, in vivo at least six different Fc gamma R ...
P J, Capel +3 more
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Clinical Immunology and Immunopathology, 1989
Considerable recent progress has been made in our understanding of how IgG immune complexes interact with plasma membrane Fc receptors (FcR) to mediate a diversity of biological responses in man. These responses include endocytosis of antibody complexes; stimulation of the secretion of various inflammatory mediators such as enzymes, oxygen products ...
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Considerable recent progress has been made in our understanding of how IgG immune complexes interact with plasma membrane Fc receptors (FcR) to mediate a diversity of biological responses in man. These responses include endocytosis of antibody complexes; stimulation of the secretion of various inflammatory mediators such as enzymes, oxygen products ...
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International Reviews of Immunology, 1989
Human lymphocytes bear at least three different classes of Fc gamma R, which are different in cellular distribution, structure, and function. This review deals with recent advances in understanding the complexity of huFc gamma R. In particular, studies demonstrating the presence of alternate phosphatidyl inositol glycan-anchored and transmembrane ...
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Human lymphocytes bear at least three different classes of Fc gamma R, which are different in cellular distribution, structure, and function. This review deals with recent advances in understanding the complexity of huFc gamma R. In particular, studies demonstrating the presence of alternate phosphatidyl inositol glycan-anchored and transmembrane ...
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The Unique Inhibitory IgG Receptor--FcγRIIb
Protein & Peptide Letters, 2018FcγRIIb is the only inhibitory IgG receptor, which is divided into three subtypes of FcγRIIb1, FcγRIIb2 and FcγRIIb3. It is mainly responsible for the immune balance in vivo by cross-linking with the activated receptor to intracellular transduction inhibitory signals, and it plays an important biological role in the negative regulation of innate ...
Zhenzhen, Xu +6 more
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