Results 81 to 90 of about 3,330,792 (348)

LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory

Brain : a journal of neurology, 2018
Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), which interacts with voltage-gated ...
M. Petit-Pedrol, Josefine Sell, J. Planagumà, F. Mannara, Marija Radosevic, H. Haselmann, M. Ceanga, L. Sabater, Marianna Spatola, David Soto, X. Gasull, J. Dalmau, C. Geis   +12 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Nature Communications
IgG secreted by B cells carry asparagine N(297)-linked glycans in the fragment crystallizable (Fc) region. Changes in Fc glycosylation are related to health or disease and are functionally relevant, as IgG without Fc glycans cannot bind to Fcɣ receptors ...
Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson, René E. M. Toes   +8 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

IgG Glyco-Engineering to Improve IVIg Potency

Frontiers in Immunology, 2018
Intravenous immunoglobulins (IVIg) are used in the treatment of different autoimmune and inflammatory diseases, such as immune thrombocytopenia and hemolytic anemia.
Christine W. Bruggeman, Gillian Dekkers, Remco Visser, Naneth W. M. Goes, Timo K. van den Berg, Theo Rispens, Gestur Vidarsson, Taco W. Kuijpers, Taco W. Kuijpers   +8 more
doaj   +1 more source

Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules. [PDF]

, 2001
Ly49 receptor genes are expressed by subsets of natural killer (NK) cells in an overlapping fashion, accounting for the capacity of NK subsets to attack host cells that have selectively downregulated self-major histocompatibility complex (MHC) class I ...
Hanke, T, Jamieson, A, RAULET, David H., Takizawa, H, Tanamachi, D   +4 more
core   +1 more source

Molecular signatures of a TLR4 agonist-adjuvanted HIV-1 vaccine candidate in humans [PDF]

, 2018
Systems biology approaches have recently provided new insights into the mechanisms of action of human vaccines and adjuvants. Here, we investigated early transcriptional signatures induced in whole blood of healthy subjects following vaccination with a ...
Anderson, J, Harandi, AM, Kratochvil, S, McKay, PF, Olafsdottir, TA, Persson, J, Shattock, RJ, östensson, M   +7 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tissue-specific expression of IgG receptors by human macrophages ex vivo.

PLoS ONE, 2019
Recently it was discovered that tissue-resident macrophages derive from embryonic precursors, not only from peripheral blood monocytes, and maintain themselves by self-renewal.
Christine W Bruggeman, Julia Houtzager, Barbara Dierdorp, Jesper Kers, Steven T Pals, René Lutter, Thomas van Gulik, Joke M M den Haan, Timo K van den Berg, Robin van Bruggen, Taco W Kuijpers   +10 more
doaj   +1 more source

THE INDIVIDUAL DIFFERENCE OF ABILITY BINDING BRAIN TUMOR CELLS WITH IMMUNOGLOBULIN G

Медицинская иммунология, 2014
. Were researched IgG on the surface cells of different histological types tumors of cerebrum, using fluorescing staphylococcus A-protein. The study of target IgG shows divers intensive of microscopic fluorescent illumination.
O. V. Ostreiko, S. V. Mozhaev, V. E. Olushin, R. A. Pantina, M. V. Filatov   +4 more
doaj   +1 more source