Results 241 to 250 of about 503,937 (310)

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

What is new on the horizon for the biologics world: New kids of the block - WAO state of art. [PDF]

World Allergy Organ J
Canonica GW, Ortega-Martell JA, Villarreal-González RV, Ansotegui IJ, Bachert C, Bernstein J, Bleecker E, Bondi B, Caminati M, Carr T, Cianferoni A, González ID, Díaz SG, Gómez RM, Hanania N, Heffler E, Nair P, Öztop N, Park HS, Pitè H, Rouadi P, Saito H, Triggiani M, Varricchi G, Virchow C, Yamada Y, Yáñez A, Morais-Almeida M.   +27 more
europepmc   +1 more source

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

Comparative toxicity of menthol- and tobacco-flavored electronic cigarette constituents inducing inflammation, epithelial barrier dysfunction, and nicotinic acetylcholine receptor modulation in the absence of nicotine. [PDF]

Toxicol Rep
Pandya V, Bhatnagar A, Beck KJ, Muthumalage T.   +3 more
europepmc   +1 more source

Early Cytokine Profiles in Critically Ill Patients with COVID-19 and Their Association with Mortality. [PDF]

Metabolites
Gamarra-Morales Y, Molina-López J, Machado-Casas JF, Herrera-Quintana L, Vázquez-Lorente H, Pérez-Villares JM, Planells E.   +6 more
europepmc   +1 more source

Microglia, Astrocytes, and Oligodendrocytes in Parkinson's Disease: Neuroinflammatory Crosstalk and Emerging Therapeutic Strategies. [PDF]

Biomolecules
Kędzia D, Galita G, Majsterek I, Rozpędek-Kamińska W.   +3 more
europepmc   +1 more source

Purinergic Signaling, HIF, and ROS Interactions in Myocardial I/R Injury: Therapeutic Potential and Future Prospective. [PDF]

Cells
Singh MK, Yun HR, Ranbhise J, Han S, Seo H, Yeo SG, Quan FS, Kim SS, Kang I.   +8 more
europepmc   +1 more source

Putative α7-selective ligands interact with α9-containing nicotinic acetylcholine receptors and modulate immune functions of human mononuclear phagocytes. [PDF]

Front Immunol
Mobasher M, Hone AJ, Pilzecker M, Bozic D, Hecker A, McIntosh JM, Kirschner KN, Grau V, Papke RL, Andleeb H, Richter K.   +10 more
europepmc   +1 more source

Characteristics of NK cells activation following IL-12, IL-15, IL-18 cytokines stimulation for preclinical purposes. [PDF]

Sci Rep
Czapla J, Drzyzga A, Smolarczyk R.
europepmc   +1 more source