Results 271 to 280 of about 479,777 (310)
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Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective
Biochemical and Biophysical Research Communications, 1997Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream.
Loddick, Sarah A. +5 more
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Fertility and Sterility, 1995
To address indirectly the possibility that the ovarian action(s) of interleukin (IL)-1 are receptor mediated and to re-examine the recently reported proposition that the naturally occurring IL-1 receptor antagonist (IL-1ra) may in fact act in the capacity of mixed IL-1 receptor agonist/antagonist.In vitro treatment of isolated granulosa cell (GC) and ...
Ehud Kokia +2 more
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To address indirectly the possibility that the ovarian action(s) of interleukin (IL)-1 are receptor mediated and to re-examine the recently reported proposition that the naturally occurring IL-1 receptor antagonist (IL-1ra) may in fact act in the capacity of mixed IL-1 receptor agonist/antagonist.In vitro treatment of isolated granulosa cell (GC) and ...
Ehud Kokia +2 more
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Interleukin-1 and Interleukin-1 Receptor Antagonist in Systemic Lupus Erythematosus
Immunological Investigations, 1997Interleukin-1 (IL-1) is thought to play an important role in the immunopathology of systemic lupus erythematosus (SLE). IL-1 receptor antagonist (IL-1ra) exhibits a dose-responsive inhibition of IL-1 effects, and Fcr receptors play a key role in IL-1ra production.
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Human Immunology, 1993
The binding of IL-1 alpha and IL-1 beta to two human lymphoblastoid B-cell lines, Raji and RPMI 1788, was compared with binding to the murine T-cell line, EL4. Dramatic differences in IL-1 binding were observed. Both human B-cell lines bound much less IL-1 alpha than IL-1 beta, expressed 5-10 times more receptors per cell for IL-1 beta than did the EL4
Richard I. Cronkhite +2 more
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The binding of IL-1 alpha and IL-1 beta to two human lymphoblastoid B-cell lines, Raji and RPMI 1788, was compared with binding to the murine T-cell line, EL4. Dramatic differences in IL-1 binding were observed. Both human B-cell lines bound much less IL-1 alpha than IL-1 beta, expressed 5-10 times more receptors per cell for IL-1 beta than did the EL4
Richard I. Cronkhite +2 more
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Synovial interleukin‐1 receptor antagonist and interleukin‐1 balance in rheumatoid arthritis
Arthritis & Rheumatism, 1994AbstractObjective. To quantify interleukin‐1 receptor antagonist (IL‐1ra) and IL‐1 production and gene expression by rheumatoid arthritis (RA) synovial tissue (ST) cells.Methods. IL‐1α, IL‐1β, and IL‐1ra protein levels were measured by enzyme‐linked immunosorbent assay in fresh and cultured ST cells, purified synovial macrophages, and fibroblast‐like ...
Gary S. Firestein +6 more
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A critical role for interleukin‐1 receptor accessory protein in interleukin‐1 signaling
European Journal of Immunology, 1997AbstractInterleukin‐1 (IL‐1) is a central molecule in inflammation and immune responses whose pleiotropic activities are mediated by the type I IL‐1 receptor (IL‐1RI). The IL‐1RI alone on the cell surface is silent after binding of the ligand. We show that the recently identified IL‐1RI accessory protein (IL‐1RAcP) converts the silent into a fully ...
Werner Falk +3 more
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Effects of Interleukin-1 and Interleukin-1 Receptor Antagonist in AIDS-Kaposiʼs Sarcoma
Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology, 1995Kaposi's sarcoma (KS) is the most common tumor seen in patients with HIV-1 infection. HIV-1 may induce KS directly through viral protein(s) or indirectly through regulation of cytokines such as IL-1 and IL-6. We have shown that AIDS-KS spindle cells express IL-1 beta and that IL-1ra inhibits KS-spindle cell growth.
Bruce Jung +7 more
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Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1991The recent purification and characterization of an interleukin 1-receptor antagonist (IL-1ra) has provided an additional means of elucidating the mechanisms involved in the responses initiated by IL-1. Central administration of IL-1 to rabbits results in a characteristic febrile response and in increased non-rapid-eye-movement sleep (NREMS).
Mark R. Opp, James M. Krueger
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Characterization of Interleukin-1 Receptors
1987The inflammatory response to disease and injury involves a variety of physiological events, amongst which are fever, release of acute phase proteins, the immune response and connective tissue breakdown and remodeling (1). Recent advances in analytical methods, in particular molecular biology, have led to the characterization of several polypeptides ...
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Overview of the interleukin-1 family of ligands and receptors
Seminars in Immunology, 2013This issue of Seminars in Immunology on The Interleukin-1 (IL-1) Family of Ligands and Receptors updates the rapidly expanding importance of this family. There are individual chapters on IL-1α, IL-1β, processing and secretion of IL-1β, IL-18, IL-33, IL-36 and IL-37.
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