Results 261 to 270 of about 30,474,151 (303)

Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

Biochemical and Biophysical Research Communications, 1997
Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream.
Loddick, Sarah A., Wong, Ma Li, Bongiorno, Peter B., Gold, Philip W., Licinio, Julio, Rothwell, Nancy J.   +5 more
openaire   +3 more sources

Interleukin-1 and Interleukin-1 Receptor Antagonist in Systemic Lupus Erythematosus

Immunological Investigations, 1997
Interleukin-1 (IL-1) is thought to play an important role in the immunopathology of systemic lupus erythematosus (SLE). IL-1 receptor antagonist (IL-1ra) exhibits a dose-responsive inhibition of IL-1 effects, and Fcr receptors play a key role in IL-1ra production.
openaire   +2 more sources

Interleukin-1 and interleukin-1 receptor antagonist.

Nutrition (Burbank, Los Angeles County, Calif.), 1996
Cytokines are produced in disease or during immunologic challenge. Some cytokines increase host resistance to disease whereas others trigger inflammatory processes. Interleukin 1 (IL-1) and tumor necrosis factor (TNF) are pro-inflammatory cytokines that affect nearly every cell either alone or in a synergistic fashion.
openaire   +1 more source

The interleukin-1/interleukin-1-receptor interaction

Annales de l'Institut Pasteur / Immunologie, 1987
H R, MacDonald, J W, Lowenthal
openaire   +2 more sources

The interleukin-1 receptor complex and interleukin-1 signal transduction.

European cytokine network, 1997
The aim of this mini-review is to give an update on the current developments concerning the IL-1 plasma membrane receptor complex and the modes of signal transduction through the plasma membrane. The mechanisms of signal generation at the cytosolic side of the plasma membrane will be summarized.
M U, Martin, W, Falk
openaire   +1 more source

Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease

Circulation Research, 2021

exaly  

Induction of interleukin-1 and interleukin-1 receptor antagonist.

Seminars in oncology, 1997
Drugs that affect the production or action, or both, of the pleiotropic inflammatory cytokine interleukin-1 (IL-1) are predicted to have a significant impact on a variety of human diseases. The biochemical properties of IL-1 and the IL-1 receptor antagonist, the mechanism for their production, and the factors that regulate their release are discussed ...
openaire   +1 more source

Characterization of Interleukin-1 Receptors

1987
The inflammatory response to disease and injury involves a variety of physiological events, amongst which are fever, release of acute phase proteins, the immune response and connective tissue breakdown and remodeling (1). Recent advances in analytical methods, in particular molecular biology, have led to the characterization of several polypeptides ...
openaire   +1 more source

Biology and therapeutic potential of interleukin-10

Journal of Experimental Medicine, 2020
Anne O'Garra, Margarida Saraiva, Paulo Vieira   +2 more
exaly  

Interleukin-22: Immunobiology and Pathology

Annual Review of Immunology, 2015
Jarrod Dudakov, Alan Hanash
exaly