Results 291 to 300 of about 1,451,004 (331)

Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1991
The recent purification and characterization of an interleukin 1-receptor antagonist (IL-1ra) has provided an additional means of elucidating the mechanisms involved in the responses initiated by IL-1. Central administration of IL-1 to rabbits results in a characteristic febrile response and in increased non-rapid-eye-movement sleep (NREMS).
M R, Opp, J M, Krueger
openaire   +2 more sources

Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.

Alimentary Pharmacology & Therapeutics, 1996
Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
F, Cominelli, T T, Pizarro
openaire   +2 more sources

Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

Biochemical and Biophysical Research Communications, 1997
Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream.
Loddick, Sarah A., Wong, Ma Li, Bongiorno, Peter B., Gold, Philip W., Licinio, Julio, Rothwell, Nancy J.   +5 more
openaire   +3 more sources

Interleukin-1 receptor antagonism.

Seminars in nephrology, 1997
Interleukin-1 (IL-1) is a pro-inflammatory cytokine that exerts a wide range of biological effects. The recently identified IL-1 receptor antagonist (IL-1ra) has provided a tool for blocking IL-1 activity in vivo, leading to a detailed understanding of the role of this cytokine in the inflammatory response.
D J, Nikolic-Paterson, H Y, Lan, R C, Atkins   +2 more
openaire   +1 more source

Interleukin-1 and Interleukin-1 Receptor Antagonist in Systemic Lupus Erythematosus

Immunological Investigations, 1997
Interleukin-1 (IL-1) is thought to play an important role in the immunopathology of systemic lupus erythematosus (SLE). IL-1 receptor antagonist (IL-1ra) exhibits a dose-responsive inhibition of IL-1 effects, and Fcr receptors play a key role in IL-1ra production.
openaire   +2 more sources

Interleukin-1 and interleukin-1 receptor antagonist.

Nutrition (Burbank, Los Angeles County, Calif.), 1996
Cytokines are produced in disease or during immunologic challenge. Some cytokines increase host resistance to disease whereas others trigger inflammatory processes. Interleukin 1 (IL-1) and tumor necrosis factor (TNF) are pro-inflammatory cytokines that affect nearly every cell either alone or in a synergistic fashion.
openaire   +1 more source

Immunological and inflammatory functions of the interleukin-1 family.

Annual Review of Immunology, 2009
C. Dinarello
semanticscholar   +1 more source

The interleukin-1/interleukin-1-receptor interaction

Annales de l'Institut Pasteur / Immunologie, 1987
H R, MacDonald, J W, Lowenthal
openaire   +2 more sources

Interleukin-1 receptor antagonist

2000
Interleukin-1 (IL-1) is a proinflammatory cytokine produced by a wide variety of cell types with an equally pleiotropic range of activities including the induction of fever, hypotension, adhesion molecule expression, neutrophilia, cartilage destruc­tion, prostanoid production, and induction of the expression of a number of other cytokines. Two forms of
openaire   +1 more source

Toll-Like Receptors, Interleukin 1 and NFκB

, 2015
J. Robert
semanticscholar   +1 more source