Results 81 to 90 of about 503,937 (310)

Interleukin 1 , interleukin 1  and interleukin 1 receptor gene polymorphisms in psoriatic arthritis [PDF]

Rheumatology, 2004
Objectives. To investigate polymorphisms of interleukin (IL) 1, IL-1 and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement. Methods. One hundred and forty well-characterized patients with PsA were studied.
openaire   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Regulatory role of IL-1R8 in immunity and disease

Frontiers in Immunology, 2016
Interleukin-1 receptor family members (ILRs) and Toll Like Receptors (TLRs) are characterized by the presence of a conserved intracellular domain, the Toll/IL-1resistance (TIR) domain and are key players in immunity and inflammation.
Martina eMolgora, Isabella eBarajon, Alberto eMantovani, Alberto eMantovani, Cecilia eGarlanda   +4 more
doaj   +1 more source

Evolution of Th2 responses : Characterization of IL-4/13 in sea bass (Dicentrarchus labrax L.) and studies of expression and biological activity [PDF]

, 2017
Acknowledgements This research was funded by the European Commission under the 7th Framework Programme for Research and Technological Development (FP7) of the European Union (Grant Agreement 311993 TARGETFISH). T.W.
A Antczak, A Bhattacharjee, A Munitz, AE Lockyer, E Wangkahart, EJ Song, F Buonocore, F Takizawa, G Biswas, G Scapigliati, H Nielsen, J Zhu, J Zou, JE Allen, JH Li, JW Hodgkinson, K Bao, K Tamura, L-y Zhu, LM Braden, M Howard, M Ohtani, M Tine, M Wills-Karp, MG Reese, MM Costa, MO Huising, N Nunez Ortiz, PJ Lupardus, RC Edgar, RL Coffman, S Almeria, S Kumar, S McCormick, SP Gadani, T Hage, T Maehr, T Wang, T Wang, T Wang, T Wang, T Yamaguchi, T Yamaguchi, TA Wynn, TA Wynn   +44 more
core   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Emerging interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer

Acta Pharmaceutica Sinica B
Interleukin-1 receptor-related kinase (IRAK4) is a widely expressed serine/threonine kinase involved in the regulation of innate immunity. IRAK4 plays a pivotal role as a key kinase within the downstream signaling pathway cascades of interleukin-1 ...
Yifan Feng, Chengjuan Chen, Anqi Shao, Lei Wu, Haiyu Hu, Tiantai Zhang   +5 more
doaj   +1 more source

TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor family member with regulatory functions in inflammation and immunity

Frontiers in Immunology, 2012
Interleukin-1R like receptors (ILRs) and Toll Like Receptors (TLRs) are key receptors of innate immunity, inflammation and orientation of the adaptive response.
Federica eRiva, Eduardo eBonavita, Elisa eBarbati, Elisa eBarbati, Marta eMuzio, Alberto eMantovani, Alberto eMantovani, Cecilia eGarlanda   +7 more
doaj   +1 more source

The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]

, 2010
The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Cockburn, Emma, Nimmo, Myra, Robson-Ansley, Paula, Stevenson, Emma, Walshe, Ian   +4 more
core  

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance [PDF]

, 2012
INTRODUCTION Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA).
Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Sacre, Sandra, Williams, Richard   +5 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source