Results 281 to 290 of about 475,125 (292)
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Disseminated BCG in an infant with interleukin-12 receptor B1 (IL12RB1) deficiency
Paediatrics and International Child Health, 2014Although neonatal vaccination with bacille Calmette-Guérin (BCG) is considered to be safe, complications with disseminated disease are associated with underlying immuno-deficiency disorders. A BCG-vaccinated 4-month-old girl of Sri Lankan parentage developed progressive left axillary lymphadenopathy and severe bronchopneumonia.
Manouri P, Senanayake +3 more
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A CASE OF INTERLEUKIN-12 RECEPTOR β-1 DEFICIENCY WITH RECURRENT LEISHMANIASIS
Pediatric Infectious Disease Journal, 2007Interleukin-12 receptor beta-1 (IL-12Rbeta1) defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. Patients rarely experience infections caused by other organisms. We report a 5-year-old patient with IL-12Rbeta1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. The
Ozden, Sanal +7 more
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Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients
Science, 1998Interleukin-12 (IL-12) is a cytokine that promotes cell-mediated immunity to intracellular pathogens by inducing type 1 helper T cell (T H 1) responses and interferon-γ (IFN-γ) production. IL-12 binds to high-affinity β1/β2 heterodimeric IL-12 receptor (IL-12R) complexes on T cell and natural killer cells.
R, de Jong +11 more
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Production of interleukin-12 and expression of its receptors by murine microglia
Brain Research, 1998Production of interleukin-12 (IL-12) by cultured murine microglia and astrocytes was examined, by means of ELISA to detect heterodimeric p70 and RT-PCR to analyze the expression of mRNA encoding p35 and p40. Microglia, but not astrocytes, produced IL-12 p70 in response to lipopolysaccharide and interferon-gamma.
A, Suzumura, M, Sawada, T, Takayanagi
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Cutaneous leukocytoclastic vasculitis in a child with interleukin-12 receptor beta-1 deficiency
The Journal of Pediatrics, 2006We report a patient with complete interleukin-12 receptor beta-1 deficiency associated with cutaneous leukocytoclastic vasculitis. The patient experienced Bacille Calmette Guérin, Mycobacterium chelonae, and Salmonella enteritidis infection. Vasculitis affecting both small arteries and postcapillary venules due to deposition of immune complexes was ...
Kutukculer, N +7 more
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Blood, 2000
Interleukin (IL)-12 plays a critical role in modulating the activities of natural killer (NK) cells and T lymphocytes. In animal models, IL-12 has potent antitumor effects that are likely mediated by its ability to enhance the cytotoxic activity of NK cells and cytotoxic T lymphocytes, and to induce the production of interferon (IFN)-γ by NK and T ...
K S, Wang, D A, Frank, J, Ritz
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Interleukin (IL)-12 plays a critical role in modulating the activities of natural killer (NK) cells and T lymphocytes. In animal models, IL-12 has potent antitumor effects that are likely mediated by its ability to enhance the cytotoxic activity of NK cells and cytotoxic T lymphocytes, and to induce the production of interferon (IFN)-γ by NK and T ...
K S, Wang, D A, Frank, J, Ritz
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European Journal of Immunology, 1997
AbstractInterferon‐γ (IFN‐γ) and interleukin‐4 (IL‐4) are mutually antagonistic cytokines that stimulate CD4+ T cells to develop into either Th1 or Th2 cells. One feature of Th2 differentiation in mice is the loss of IL‐12‐induced Jak2 and Stat4 activation, which is accompanied by the inability to produce IFN‐γ in response to IL‐12.
J A, Gollob, H, Kawasaki, J, Ritz
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AbstractInterferon‐γ (IFN‐γ) and interleukin‐4 (IL‐4) are mutually antagonistic cytokines that stimulate CD4+ T cells to develop into either Th1 or Th2 cells. One feature of Th2 differentiation in mice is the loss of IL‐12‐induced Jak2 and Stat4 activation, which is accompanied by the inability to produce IFN‐γ in response to IL‐12.
J A, Gollob, H, Kawasaki, J, Ritz
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Molecular cloning of interleukin-12 receptor β2 chain and its expression in dogs
Veterinary Immunology and Immunopathology, 2005This study cloned canine interleukin-12 receptor beta2 (IL-12Rbeta2). Its nucleotide sequences were determined. Canine IL-12Rbeta2 showed 85.4% homology at the nucleotide level and 76.8% homology at the amino acid level with human IL-12Rbeta2. Its structural motifs were well conserved.
Eri, Kitamiya +2 more
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