IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma [PDF]
PeerJ, 2022 Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid.
Siti Muhamad Nur Husna +3 more
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The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
Frontiers in Medicine, 2023 Recent evidence suggests that interleukin (IL)-13 is a crucial cytokine involved in the pathogenesis of atopic dermatitis (AD). It is a central driver of type-2 T-helper inflammation and is overexpressed in lesional skin of AD patients.
Maddalena Napolitano +4 more
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IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma. [PDF]
PLoS ONE, 2018 Diffuse intrinsic pontine glioma (DIPG) is a universally fatal childhood cancer of the brain. Despite the introduction of conventional chemotherapy and radiotherapy, improvements in survival have been marginal and long-term survivorship is uncommon. Thus,
Noah E Berlow +12 more
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Frontiers in Immunology, 2023 Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases.
Kayleigh Walker +15 more
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A Case of Papuloerythroderma Successfully Treated with Dupilumab
Case Reports in Dermatology, 2022 Papuloerythroderma is an erythroderma characterized by the composition of dense paving stone shape papules and intertriginous uninvolved skin on the abdominal wall and is often intractable and accompanied by itching.
Ayaka Mizuno +4 more
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Mutants of Interleukin 13 with Altered Reactivity toward Interleukin 13 Receptors [PDF]
Journal of Biological Chemistry, 1999 Interleukin 13 (IL13) belongs to a family of cytokines whose members exhibit structural homology, despite amino acid sequence dissimilarity. For example, while of limited sequence homology, IL13 and IL4 share a signaling receptor, IL13/4 receptor, on a variety of human normal cells. However, a subclass of IL4-independent IL13 receptors is overexpressed
J P, Thompson, W, Debinski
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Dupilumab: Basic aspects and applications to allergic diseases
Allergology International, 2020 Interleukin (IL)-4 and IL-13, signature type 2 cytokines, exert their actions by binding to two types of receptors sharing the IL-4R α chain (IL-4Rα).
Kazuto Matsunaga +4 more
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Characterization of the Interaction between Interleukin-13 and Interleukin-13 Receptors [PDF]
Journal of Biological Chemistry, 2005 Interleukin-13 (IL-13) possesses two types of receptor: the heterodimer, composed of the IL-13Ralpha1 chain (IL-13Ralpha1) and the IL-4Ralpha chain (IL-4Ralpha), transducing the IL-13 signals; and the IL-13Ralpha2 chain (IL-13Ralpha2), acting as a nonsignaling "decoy" receptor.
Kazuhiko, Arima +8 more
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Interleukin-13 Receptor Alpha 2-Targeted Glioblastoma Immunotherapy [PDF]
BioMed Research International, 2014 Glioblastoma (GBM) is the most lethal primary brain tumor, and despite several refinements in its multimodal management, generally has very poor prognosis. Targeted immunotherapy is an emerging field of research that shows great promise in the treatment of GBM.
Sadhak Sengupta +3 more
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Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]
, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
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