Results 1 to 10 of about 446,404 (190)

Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes [PDF]

Mediators of Inflammation, 2015
Interleukin-18 is a proinflammatory cytokine belonging to the interleukin-1 family of cytokines. This cytokine exerts many unique biological and immunological effects.
Luciane Alarcão Dias-Melicio, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Marjorie Assis Golim, Angela Maria Victoriano Campos Soares   +4 more
doaj   +5 more sources

Cannabidiol reduces LPS-induced inflammatory response in the human placenta by reducing NF-κB translocation [PDF]

Journal of Cannabis Research
Background Cannabidiol (CBD), a non-psychoactive cannabinoid increasingly used during pregnancy, has been proposed to modulate inflammatory processes. However, its effects on human placental immune functions remain poorly characterized.
Ramon Portillo, Tetiana Synova, Mohammad Rida Ghaddar, Mia Salma Alsouki, Fiona Kumnova, Miloslav Machacek, Rona Karahoda, Cilia Abad, Frantisek Staud   +8 more
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Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice

Frontiers in Immunology, 2022
Natural killer (NK) cells are important effectors of the innate immune system and participate in the first line of defense against infections and tumors.
Neha D. Patil, Neha D. Patil, Olivia Domingues, Cécile Masquelier, Maud Theresine, Oceane Schlienger, Clinton Njinju Amin Asaba, Marine Thomas, Carole Seguin-Devaux, Hortense Slevogt, Markus Ollert, Markus Ollert, Jacques Zimmer   +12 more
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Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

Frontiers in Immunology, 2021
In recent years, chimeric antigen receptor T cells (CAR-T cells) have been faced with the problems of weak proliferation and poor persistence in the treatment of some malignancies.
Zhengchao Zhang, Zhengchao Zhang, Lele Miao, Lele Miao, Zhijian Ren, Zhijian Ren, Futian Tang, Futian Tang, Yumin Li, Yumin Li   +9 more
doaj   +1 more source

Interleukin-18 and interleukin-18 receptor-α expression in allergic asthma [PDF]

European Respiratory Journal, 2011
To the Editors: The inflammatory process in allergic asthma is initiated by T-helper (Th) type-2 cells, which produce a repertoire of cytokines, including interleukin (IL)-4, IL-5, IL-9 and IL-13, which are necessary for immunoglobulin (Ig)E production, airway eosinophilia and goblet cell hyperplasia [1].
H, Imaoka, G M, Gauvreau, R M, Watson, S G, Smith, B, Dua, A J, Baatjes, K, Howie, T, Hoshino, K J, Killian, H, Aizawa, P M, O'Byrne   +10 more
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The Effects of Pro-Inflammatory Cytokines on Human Body and Their Relation with Diseases (Review Article)

Academic Science Journal, 2023
Cytokines are important mediators in inflammatory disorders that affect the entire body. Signaling molecules called pro-inflammatory cytokines, also known as inflammatory cytokines, are released by the immune system cells including macrophages and T ...
Khalid Shaalan Sahab , Mohammed Asaad Mahdi, Ammar M. K. AL-Azzawi   +2 more
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Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation [PDF]

Nature Immunology, 2006
T helper type 1 (T(H)1) lymphocytes are considered to be the main pathogenic cell type responsible for organ-specific autoimmune inflammation. As interleukin 18 (IL-18) is a cofactor with IL-12 in promoting T(H)1 cell development, we examined the function of IL-18 and its receptor, IL-18R, in autoimmune central nervous system inflammation.
Gutcher, I, Urich, E, Wolter, K, Prinz, M, Becher, B   +4 more
openaire   +4 more sources

Interleukin-18 Stimulates a Positive Feedback Loop During Renal Obstruction via Interleukin-18 Receptor [PDF]

Journal of Urology, 2011
Interleukin-18 is a proinflammatory cytokine that is an important mediator of obstruction induced renal tubulointerstitial fibrosis independent of tumor necrosis factor-α and β1 activity. We hypothesized that interleukin-18 stimulates a positive feedback loop during obstruction via interleukin-18 receptor to increase interleukin-18 gene expression and ...
VanderBrink, Brian A., Asanuma, Hiroshi, Hile, Karen, Zhang, Honji, Rink, Richard C., Meldrum, Kirstan K.   +5 more
openaire   +2 more sources

Interleukin 18 function requires both interleukin 18 receptor and Na-Cl co-transporter [PDF]

Nature Medicine, 2015
Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms(1,2). Interruption of IL18 action reduces atherosclerosis in mice(3,4). This study shows that the absence of IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E-deficient (Apoe(−/−)) mice, nor does it affect IL18 cell surface binding or ...
Wang, Jing, Sun, Chongxiu, Gerdes, Norbert, Liu, Conglin, Liao, Mengyang, Liu, Jian, Shi, Michael A., He, Aina, Zhou, Yi, Sukhova, Galina K., Chen, Huimei, Cheng, Xianwu, Kuzuya, Masafumi, Murohara, Toyoaki, Zhang, Jie, Cheng, Xiang, Jiang, Mengmeng, Shull, Gary E., Rogers, Shaunessy, Yang, Chao-Ling, Ke, Qiang, Jelen, Sabina, Bindels, René, Ellison, David H., Jarolim, Petr, Libby, Peter, Shi, Guo-Ping   +26 more
openaire   +5 more sources

Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation

Nature Communications, 2022
Interleukin-18 (IL18) has a pivotal role in interferon signalling and T cell development, but increasingly recognized as an adipokine that regulates energy metabolism in fat tissue.
Xian Zhang, Songyuan Luo, Minjie Wang, Qiongqiong Cao, Zhixin Zhang, Qin Huang, Jie Li, Zhiyong Deng, Tianxiao Liu, Cong-Lin Liu, Mathilde Meppen, Amelie Vromman, Richard A. Flavell, Gökhan S. Hotamışlıgil, Jian Liu, Peter Libby, Zhangsuo Liu, Guo-Ping Shi   +17 more
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