Results 11 to 20 of about 61,846,700 (305)

IL21R (interleukin 21 receptor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on IL21R (interleukin 21 receptor), with data on DNA, on the protein encoded, and where the gene is implicated.
Ferrini, S, Fabbi, M
core   +8 more sources

Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]

, 2010
PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core   +4 more sources

Polymorphisms of interleukin-21 and interleukin-21-receptor genes confer risk for autoimmune thyroid diseases [PDF]

BMC Endocrine Disorders, 2013
The abnormality of interleukin-21 (IL-21)-IL-21-receptor (IL-21R) system has been found in many autoimmune diseases including autoimmune thyroid diseases (AITDs). In this study, we investigated whether polymorphisms of the IL-21 and IL-21R are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITDs, among a ...
Zhang, Jian, Xiao, Wan Xia, Zhu, Yuan Feng, Muhali, Fatuma Said, Xiao, Ling, Jiang, Wen Juan, Shi, Xiao Hong, Zhou, Lian Hua, Zhang, Jin An   +8 more
openaire   +2 more sources

Interleukin-21 Receptor Gene Polymorphisms in Kawasaki Disease [PDF]

Korean Circulation Journal, 2013
Interleukin-21 receptor (IL-21R) gene polymorphism is related with the development of systemic vasculitis. In this study, we investigated the polymorphisms of IL-21R gene in patients with Kawasaki disease (KD).We genotyped the promoter region of IL-21R gene (-2500 bp to +1 bp) in 100 patients with KD and 100 healthy controls.
Kim, Mi Hyun, Bae, Yon Jung, Lee, Hyun Keun, Lee, Yeong Ro, Lee, Dong Hoon, Bae, Kiho, Koh, Sang Baek, Namgoong, Mee Kyung, Cha, Byung Ho, Lee, Hae Yong   +9 more
openaire   +2 more sources

Expression of interleukin‐21 receptor in epidermis from patients with systemic sclerosis [PDF]

Arthritis & Rheumatism, 2005
AbstractObjectiveTo examine the expression and regulation of interleukin‐21 (IL‐21) and IL‐21 receptor (IL‐21R) in patients with systemic sclerosis (SSc; scleroderma).MethodsSkin biopsy specimens were obtained from 23 patients with SSc and 15 healthy controls.
DISTLER JH, JUNGEL A, KOWAL BIELECKA O, MICHEL BA, GAY RE, SPROTT H, MATUCCI CERINIC, MARCO, CHILLA M, REICH K, KALDEN JR, MULLER LADNER U, LORENZ HM, GAY S, DISTLER O.   +13 more
openaire   +6 more sources

Blockade of the interleukin‐21/interleukin‐21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 2007
AbstractObjectiveInterleukin‐21 (IL‐21) is a T cell–derived cytokine that modulates T cell, B cell, and natural killer cell responses. In this study, the effects of blocking IL‐21 were examined in 2 rodent models of rheumatoid arthritis (RA) to determine whether IL‐21 contributes to their pathologic processes.MethodsDBA/1 mice were immunized with ...
Deborah A, Young, Martin, Hegen, Hak Ling Margery, Ma, Matthew J, Whitters, Leo M, Albert, Leslie, Lowe, Mayra, Senices, Paul W, Wu, Barbara, Sibley, Yelena, Leathurby, Tom P, Brown, Cheryl, Nickerson-Nutter, James C, Keith, Mary, Collins   +13 more
openaire   +2 more sources

Expression of interleukin‐21 receptor, but not interleukin‐21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 2004
AbstractObjectiveTo determine the role and expression of the cytokine/receptor pair interleukin‐21 (IL‐21)/IL‐21 receptor (IL‐21R) in rheumatoid arthritis (RA).MethodsThe expression of IL‐21R and IL‐21 was analyzed by TaqMan real‐time polymerase chain reaction (PCR) and in situ hybridization of synovial biopsy samples from patients with RA and ...
Jüngel A, Distler JH, Kurowska-Stolarska M, Seemayer CA, Seibl R, Forster A, Michel BA, Gay RE, Emmrich F, Gay S, Distler O   +10 more
openaire   +3 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A., Reading, Patrick   +25 more
core   +1 more source

Characterisation of bovine leukocyte Ig-like receptors [PDF]

, 2012
Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have ...
Jones, DC, Singh, M, Allen, RL, Trowsdale, J, Laing, K, Butcher, P, Bhuju, S, Hogan, L, Vordermeier, M   +8 more
core   +3 more sources

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Frontiers in Immunology, 2019
Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines.
Yi Wang, Hua Jiang, Hong Luo, Yansha Sun, Bizhi Shi, Ruixin Sun, Zonghai Li, Zonghai Li   +7 more
doaj   +1 more source