Results 21 to 30 of about 61,846,700 (305)

Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis

Chinese Medical Journal, 2017
The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood. Many cytokines play a pathogenic role in DM and PM. Interleukin 21 (IL-21) has a pleiotropic effect on inflammation regulation. This study aimed to detect the serum IL-21 level and investigate the expression of IL-21 and IL-21 receptor (IL ...
Tao Liu, Ying Hou, Ting-Jun Dai, Chuan-Zhu Yan   +3 more
openaire   +3 more sources

Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells [PDF]

Stem Cells International, 2022
Dysfunctions in adipose tissue cells are responsible for several obesity-related metabolic diseases. Understanding the process of adipocyte formation is thus fundamental for understanding these diseases. The adipocyte differentiation of adipose-derived stem/stromal cells (ADSCs) showed a reduction in the mRNA level of the interleukin 21 receptor (IL21R)
Bruna Cristina Falavinha, María Julia Barisón, Carmen Lúcia Kuniyoshi Rebelatto, Bruna Hilzendeger Marcon, Alessandra de Melo Aguiar, Evelin Brandão da Silva, Marco Augusto Stimamiglio, Patrícia Shigunov   +7 more
openaire   +3 more sources

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells [PDF]

, 2008
Interleukin 2 and interleukin 15 (IL2 and IL15, respectively) provide quite distinct contributions to T-cell-mediated immunity, despite having similar receptor composition and signaling machinery.
Bodnár, Andrea, Garcia Parajo, M.F., van Dijk, E.M.H.P., Jenei, Attila, Andrea Bodnár, Thomas A. Waldmann, Garcia-Parajo, Maria F., Hulst, Niek F., van, Sándor Damjanovich, Attila Jenei, Bakker, B. I. de, van Hulst, N.F., Damjanovich, Sándor, Dóczy-Bodnár, Andrea, György Vámosi, Dijk, Erik M. H. P., van, Waldmann, Thomas A., María F. Garcia-Parajo, Niek F. van Hulst, de Bakker, Bärbel I., Vámosi, György, Erik M. H. P. van Dijk, Dijk, E. M. H. P. van, de Bakker, B.I., Bärbel I. de Bakker   +24 more
core   +1 more source

Mechanism of LSD1 in oxygen-glucose deprivation/reoxygenation-induced pyroptosis of retinal ganglion cells via the miR-21-5p/NLRP12 axis

BMC Neuroscience, 2022
Background Retinal ganglion cells (RGCs) are important retinal neurons that connect visual receptors to the brain, and lysine-specific demethylase 1 (LSD1) is implicated in the development of RGCs.
Xiuling Yu, Tongtong Niu, Chi Liu
doaj   +1 more source

An efficient feeder-free and chemically-defined expansion strategy for highly purified natural killer cells derived from human cord blood

Regenerative Therapy, 2023
Introduction: Natural killer cells (NKCs) are immune cells that can attack cancer cells through the direct recognition of ligands without prior sensitization.
Tsutomu Nakazawa, Ryosuke Maeoka, Takayuki Morimoto, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Ichiro Nakagawa, Young-Soo Park, Toshihiro Ito, Hiroyuki Nakase, Takahiro Tsujimura   +11 more
doaj   +1 more source

HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1.

PLoS Pathogens, 2013
Upon recognition of viral components by pattern recognition receptors, such as the toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like helicases, cells are activated to produce type I interferon (IFN) and proinflammatory cytokines.
Yanni Chen, Junbo Chen, Hui Wang, Jingjing Shi, Kailang Wu, Shi Liu, Yingle Liu, Jianguo Wu   +7 more
doaj   +1 more source

The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases

Journal of Immunology Research, 2020
T follicular helper (TFH) cells are recognized as a subtype of T cells that are involved in the germinal center formation and B cell development. When dysregulated, TFH cells may represent an important mechanism that contributes to a heightened humoral ...
Lin Li, Panyang Xu, Qi Zhou, Jiancheng Xu   +3 more
doaj   +1 more source

Chronic heat stress delays immune system development and alters serotonin signaling in pre-weaned dairy calves.

PLoS ONE, 2021
Exposure to heat stress can alter the development and immune system function in dairy calves. Serotonin is an immunomodulatory biogenic amine that functions as a neurotransmitter and as a stress-response mediator.
Marcela G Marrero, Bethany Dado-Senn, Sena L Field, Guan Yang, John P Driver, Jimena Laporta   +5 more
doaj   +1 more source

Endothelial interleukin-21 receptor up-regulation in peripheral artery disease [PDF]

Vascular Medicine, 2015
In most patients with symptomatic peripheral artery disease (PAD), severe stenosis in or occlusion of the major blood vessels that supply the legs make the amount of distal blood flow dependent on the capacity to induce angiogenesis and collateral vessel formation.
Tao, Wang, Alexis, Cunningham, Kevin, Houston, Aditya M, Sharma, Lingdan, Chen, Ayotunde O, Dokun, R John, Lye, Rosanne, Spolski, Warren J, Leonard, Brian H, Annex   +9 more
openaire   +2 more sources

Effects of anti-inflammatory therapies on glycemic control in type 2 diabetes mellitus

Frontiers in Immunology, 2023
BackgroundThe overall evidence base of anti-inflammatory therapies in patients with type 2 diabetes mellitus (T2DM) has not been systematically evaluated.
Dandan Li, Jiaxin Zhong, Qirui Zhang, Jingjing Zhang   +3 more
doaj   +1 more source