Results 231 to 240 of about 310,876 (265)

Circulating levels of interleukin-6, its soluble receptor and interleukin-6/interleukin-6 receptor complexes in patients with type 2 diabetes mellitus

Acta Diabetologica, 1999
We evaluated the relationship between plasma fibrinogen concentration and the serum levels of interleukin-6 (IL-6), its soluble receptor, and their complex in patients with type 2 diabetes mellitus. The study comprised 57 patients with type 2 diabetes and 15 normal healthy controls.
S, Kado, T, Nagase, N, Nagata
openaire   +2 more sources

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

Science, 1992
Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on the basis of their molecular structures.
T, Kishimoto, S, Akira, T, Taga
openaire   +2 more sources

The soluble interleukin‐6 receptor is generated by shedding

European Journal of Immunology, 1993
AbstractThe ligand‐binding subunit (gp80) of the human interleukin‐6 receptor (IL‐6R) was transiently expressed in COS‐7 cells. The metabolically labeled protein was shown to be quantitatively released from the membrane within 20 h. We identified the protein released from the transfected COS‐7 cells after purification to homogeneity and N‐terminal ...
Mülberg, Jürgen, Schooltink, Heidi, Stoyan, Tanja, Günther, Monika, Graeve, Lutz, Buse, Gerhard, Mackiewicz, Andrzej, Heinrich, Peter, Rose-John, Stefan   +8 more
openaire   +3 more sources

The soluble interleukin-6 receptor and related proteins

Best Practice & Research Clinical Endocrinology & Metabolism, 2015
Interleukin-6 is a cytokine involved in the regulation of the immune system and the central nervous system. Interleukin-6 binds to an interleukin-6 receptor, and then associates with a dimer of the ubiquitously expressed gp130 receptor subunit, which initiates intracellular signaling.
openaire   +2 more sources

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.

Cancer research, 1991
We have probed for the presence of interleukin 6 (IL6) receptors in prostatic carcinoma cell lines (LNCaP, DU 145, and PC3) by examining their sensitivity to the cytotoxic effects of a chimeric toxin composed of IL6 and Pseudomonas exotoxin (PE). All three cell lines were killed by IL6-PE66(4)Glu, a version of IL6-PE in which the binding domain of ...
C B, Siegall, G, Schwab, R P, Nordan, D J, FitzGerald, I, Pastan   +4 more
openaire   +1 more source

Interleukin-6 Receptor

2020
Stefan Rose-John, Peter C. Heinrich
openaire   +1 more source

Interleukin-6 Receptor and Signals

Chemical immunology, 1992
Tetsuya Taga, Masahiko Hibi, Masaaki Murakami, Mikiyoshi Saito, Hideo Yawata, Masashi Narazaki, Yuuichi Hirata, Takahisa Sugita, Kiyoshi Yasukawa, Toshio Hirano, Tadamitsu Kishimoto   +10 more
openaire   +3 more sources

Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease

Circulation Research, 2021

exaly  

The Soluble Interleukin‐6 Receptora

Annals of the New York Academy of Sciences, 1995
S, Rose-John, M, Ehlers, J, Grötzinger, J, Müllberg   +3 more
openaire   +2 more sources

INTERLEUKIN-6 AND SOLUBLE INTERLEUKIN-6 RECEPTOR IN SURGICAL TRAUMA

Shock, 1995
Michio Ogawa, Kiyoshi Sakamoto, Seiji Mita, Takatoshi Ishiko, Saburo Hisano   +4 more
openaire   +1 more source