Results 251 to 260 of about 496,855 (309)

Interleukin-6 and interleukin-6 receptor gene expression in pituitary tumors

Journal of Neuro-Oncology, 1994
Interleukin-6 (IL-6) is a multifunctional cytokine which plays a role in the stimulation, inhibition, differentiation, and regulation of cell growth. IL-6 has been shown to act as an autocrine growth factor in several tumors, and is expressed by a variety of tumors. IL-6 also exhibits a regulatory role in the hypothalamo-pituitary axis.
A R, Rezai, A, Rezai, O, Martínez-Maza, M, Vander-Meyden, M H, Weiss   +4 more
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Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease

Neuroscience Letters, 1998
Serum levels of interleukin-6 (IL-6) and interleukin-6 soluble receptor (IL-6sR) were measured in 41 patients (23 female and 18 male, mean age 72.5 years) with Alzheimer's disease (AD) and in 32 controls (14 women and 18 men, mean age 69.2 years) using enzyme-linked immunosorbent assays (ELISA).
P, Angelis, S, Scharf, A, Mander, F, Vajda, N, Christophidis   +4 more
openaire   +2 more sources

Serum Interleukin-6, Soluble Interleukin-6 Receptor and Crohn’s Disease Activity

Digestive Diseases and Sciences, 2007
The relationship between plasma interleukin-6 (IL-6) concentration and its soluble receptor in Crohn's disease (CD) is not well elucidated. Twenty healthy volunteers and 94 consecutive patients with CD (44 in relapse and 50 in remission) were studied. Plasma IL-6 concentrations in patients with active disease [80 +/- 9 pg/ml; mean +/- standard error of
Stéphane, Nancey, Nadim, Hamzaoui, Driffa, Moussata, Ivan, Graber, Jacques, Bienvenu, Bernard, Flourie   +5 more
openaire   +2 more sources

Anti-Interleukin-6 and Soluble Interleukin-6 Receptor in Systemic Lupus Erythematosus

Lupus, 1994
IL-6, soluble IL-6 receptor and IgG with anti-IL-6 activity were measured in the plasma of 14 lupus patients and 10 normal subjects. The capacity of peripheral blood mononuclear cells to spontaneously produce IL-6 in vitro was also measured. Our results indicate that IL-6 plasma levels in patient plasma as measured by ELISA were not different from ...
M, Evans, N I, Abdou
openaire   +2 more sources

Hodgkin and Reed-Sternberg Cells Express Interleukin 6 and Interleukin 6 Receptors

Leukemia & Lymphoma, 1992
Interleukin 6 (IL-6) is a pleiotropic lymphokine which can stimulate a variety of cells including B and T lymphocytes. It has been suggested that IL-6 plays a crucial role in several diseases such as human plasmacytoma, cardiac myxoma or Castleman's Disease by autocrine or paracrine stimulation.
H, Tesch, M, Jücker, S, Klein, H, Abts, A, Günther, G R, Krueger, V, Diehl   +6 more
openaire   +2 more sources

Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

Gastroenterology, 2000
Liver regeneration after loss of hepatic tissue leads to hepatocyte and nonparenchymal cell proliferation and rapid restoration of liver parenchyma. Interleukin (IL)-6 is a key inducer of transcription factors involved in liver regeneration. Whenever IL-6 activates target cells, it binds to a specific IL-6 receptor (IL-6R).
M, Peters, G, Blinn, T, Jostock, P, Schirmacher, K H, Meyer zum Büschenfelde, P R, Galle, S, Rose-John   +6 more
openaire   +2 more sources

Fusion Protein of Interleukin-6 and Interleukin-6 Receptor without a Polypeptide Linker

Journal of Bioscience and Bioengineering, 2003
FP6, a novel recombinant fusion protein of interleukin-6 (IL-6) and IL-6 receptor (IL-6R), was prepared in the methylotrophic yeast Pichia pastoris. This protein was a potent activator of a cell surface transducing glycoprotein, gp130 and is a potential therapeutical reagent in the hemopoietic field. A linker is generally thought to be required for two
Kiyoshi, Yasukawa, Shigeo, Tsuchiya, Teiji, Ekida, Hiroshi, Iida, Teruhiko, Ide, Daisuke, Miki, Harutaka, Yagame, Keiichi, Murayama, Takahiko, Ishiguro   +8 more
openaire   +2 more sources

Therapeutic Targeting of the Interleukin-6 Receptor

Annual Review of Pharmacology and Toxicology, 2012
Interleukin (IL)-6 is a typical cytokine featuring redundancy and pleiotropic activity. It contributes to host defense against pathogens, but dysregulation of IL-6 production plays a significant pathological role in various autoimmune and inflammatory diseases.
Toshio, Tanaka, Masashi, Narazaki, Tadamitsu, Kishimoto   +2 more
openaire   +2 more sources

Interleukin-6 receptor-interleukin-6 fusion proteins with enhanced interleukin-6 type pleiotropic activities.

European cytokine network, 1998
An sIL-6R/IL-6 chimera, directly fusing the natural forms of soluble IL-6 receptor and IL-6, as found in human body fluids, was produced in transfected human cells. The secreted p85 glycoprotein was active at a concentration of 120 pM to produce growth-arrest and spindleoid differentiation of murine melanoma F10.9 cells, which do not respond to IL-6 ...
J, Chebath, D, Fischer, A, Kumar, J W, Oh, O, Kolett, T, Lapidot, M, Fischer, S, Rose-John, A, Nagler, S, Slavin, M, Revel   +10 more
openaire   +1 more source

Interleukin-6, soluble interleukin-6 receptor/interleukin-6 complex and insulin resistance in obese children and adolescents

Journal of Endocrinological Investigation, 2014
To study the characteristics of interleukin 6 (IL6), soluble form of interleukin 6 receptor (sILR)/IL6 complex in obese children and adolescents and its relationship with insulin resistance (IR).66 obese children and adolescents [34 boys, mean age 10.3 ± 2.9 years, z-score of body mass index (BMI) 4.76 ± 1.36] and 24 non-obese healthy sex- and age ...
De Filippo, G., Rendina, D., Moccia, F., Rocco, V., Campanozzi, A.   +4 more
openaire   +4 more sources