Results 11 to 20 of about 516,089 (311)

Targeting interleukin-17 receptors

Oncotarget, 2015
During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to
Wen-Hwa, Lee, Heng-Hsiung, Wu, Chun-Kai, Huang   +2 more
openaire   +2 more sources

Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]

, 2015
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia, D’Eustachio, Peter, Masci, Anna Maria, Natale, Darren, Ruttenberg, Alan, Shamovsky, Veronica, Smith, Barry, Wu, Cathy   +7 more
core   +4 more sources

Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function

Frontiers in Immunology, 2017
The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A ...
Fabien Lavocat, Ndiémé Ndongo-Thiam, Pierre Miossec   +2 more
doaj   +1 more source

Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat [PDF]

Diabetes & Metabolism Journal
Background The CXC motif chemokine ligand 8 (CXCL8)-CXC motif chemokine receptor 1/2 (CXCR1/2) axis has been implicated in type 1 diabetes mellitus (T1DM).
Serena Boccella, Andrea Maria Morace, Cristina Giorgio, Francesca Guida, Michela Perrone, Iolanda Manzo, Carmela Belardo, Meghan Jones, Sabatino Maione, Andrea Aramini, Marcello Allegretti, Livio Luongo, Laura Brandolini   +12 more
doaj   +1 more source

Soluble interleukin-2 receptors in ulcerative colitis

Mediators of Inflammation, 1993
T-Cell activation results in the release or shedding of a soluble form (45 kDa) of the cellular (55 kDa) low-affinity interleukin-2 receptor (α-chain) (slL-2R).
O. H. Nielsen, J. Brynskov
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Expression of Interleukin-1 and Interleukin-1 Receptors Type 1 and Type 2 in Hodgkin Lymphoma. [PDF]

PLoS ONE, 2015
Signaling through the IL-1-receptor type 1 (IL-1R1), IL-1 is required for initiation and maintenance of diverse activities of the immune system. A second receptor, IL-1R2, blocks IL-1 signal transduction. We studied expression of IL-1beta, IL-1R1, and IL-
Elisabeth Oelmann, Harald Stein, Wolfgang E Berdel, Hermann Herbst   +3 more
doaj   +1 more source

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Bartlett, Nathan W, Bowie, Andrew G, Fitzgerald, Katherine A, Haga, Ismar R, Maloney, Geraldine, Reading, Patrick C, Schröder, Martina, Smith, Geoffrey L, Stack, Julianne   +8 more
core   +3 more sources

Interleukin-17 Cytokines and Receptors: Potential Amplifiers of Tendon Inflammation

Frontiers in Bioengineering and Biotechnology, 2021
Interleukin (IL)-17A, a pro-inflammatory cytokine that is linked to the pathology of several inflammatory diseases, has been shown to be upregulated in early human tendinopathy and to mediate inflammatory and tissue remodelling events.
Jolet Y. Mimpen, Sarah J. B. Snelling, Andrew J. Carr, Stephanie G. Dakin   +3 more
doaj   +1 more source

Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts [PDF]

, 2008
Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic
Bachert, Claus, Claeys, Cindy, Perez Novo, Claudina, Van Cauwenberge, Paul, Waeytens, Anouk   +4 more
core   +2 more sources