Results 11 to 20 of about 6,714 (159)

Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches. [PDF]

Reprod Domest Anim
ABSTRACT Kisspeptin is a peptide that plays a pivotal role in the central regulation of gonadotropins. It is regarded as a key regulator of reproductive processes, including follicular and luteal development and endometrial remodelling. The objective of this study was to investigate the expression of KISS1, its receptor KISS1R and the proliferation ...
Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Özmen Ö, Bozkurt G, Taşan Ş.   +4 more
europepmc   +2 more sources

GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice [PDF]

J Neuroendocrinol
Abstract The arcuate nucleus kisspeptin (ARNKISS) neurons intermittently synchronize their activity to operate as the GnRH pulse generator and drive pulsatile reproductive hormone secretion in mammals. Although ARNKISS neurons are known to receive various GABAergic inputs, the effects of GABAA and GABAB receptor modulation on their ability to ...
Eddleston T, Morris P, Herbison A.
europepmc   +2 more sources

Arcuate nucleus-specific progesterone receptor knockdown in female mice is sufficient to induce PCOS-like hyperactivity in the reproductive axis. [PDF]

J Neuroendocrinol
Abstract Mammalian reproductive function is dependent upon gonadal steroid hormone feedback within the hypothalamic–pituitary–gonadal (HPG) axis. In polycystic ovary syndrome (PCOS), impaired progesterone (P4) negative feedback leads to hyperactive pulsatile secretion of luteinising hormone (LH) and impaired reproductive function.
Glendining KA, Prescott M, Potapov K, Kip E, Campbell RE.   +4 more
europepmc   +2 more sources

Neuroendocrine plasticity and crosstalk in pubertal development. [PDF]

J Neuroendocrinol
Abstract Puberty is a critical developmental stage during which individuals acquire the capacity for sexual reproduction. This transition involves a series of complex biological events primarily orchestrated by the activation of the hypothalamo–pituitary–gonadal (HPG) axis.
Elias CF, Han X, Garcia-Galiano D, Sáenz de Miera C.   +3 more
europepmc   +2 more sources

GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness. [PDF]

PLoS ONE, 2011
Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans. However, recent
Mateusz Zajac, Jeffrey Law, Dragana Donna Cvetkovic, Macarena Pampillo, Lindsay McColl, Cynthia Pape, Gianni M Di Guglielmo, Lynne M Postovit, Andy V Babwah, Moshmi Bhattacharya   +9 more
doaj   +1 more source

The Role of Genetics in Central Precocious Puberty: Confirmed and Potential Neuroendocrine Genetic and Epigenetic Contributors and Their Interactions with Endocrine Disrupting Chemicals (EDCs)

Endocrines, 2022
Despite the growing prevalence of central precocious puberty (CPP), most cases are still diagnosed as “idiopathic” due to the lack of identifiable findings of other diagnostic etiology.
Andrea Mucci, Ethel Clemente
doaj   +1 more source

Anorexia nervosa and reproduction: connecting brain to gonads [PDF]

, 2020
Anorexia nervosa (AN) is a psychiatric disorder that predominantly affects young women and is characterized by low caloric intake and a major dissatisfaction with one’s body image.
Ciobanu, Corina, Fica, Simona, Poterasu, Mihaela, Rowland, David L.   +3 more
core   +2 more sources

Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10. [PDF]

PLoS ONE, 2014
β-cells in the pancreatic islet respond to elevated plasma glucose by secreting insulin to maintain glucose homeostasis. In addition to glucose stimulation, insulin secretion is modulated by numerous G-protein coupled receptors (GPCRs).
Tara A Schwetz, Christopher A Reissaus, David W Piston   +2 more
doaj   +1 more source

Roundup in the Reproduction of Crucian Carp (Carassius carassius): An In Vitro Effect on the Pituitary Gland and Ovary

Animals, 2022
Roundup, the most popular herbicide in global agriculture, is regarded as an endocrine disruptor causing alterations of important hormones at the hypothalamic−pituitary−gonadal axis as well as impairment of gametogenesis.
Magdalena Socha, Joanna Szczygieł, Jarosław Chyb, Ewa Drąg-Kozak, Mirosława Sokołowska-Mikołajczyk, Elżbieta Brzuska, Anna Pecio, Małgorzata Grzesiak   +7 more
doaj   +1 more source

Food deprivation differentially modulates gene expression of LPXRFa and kisspeptin systems in the brain-pituitary axis of half-smooth tongue sole (Cynoglossus semilaevis)

Frontiers in Endocrinology, 2023
LPXRFa, also known as gonadotropin-inhibitory hormone (GnIH), and kisspeptin (Kiss) are two major hypothalamic peptides that modulate the reproductive axis of vertebrates, including teleosts. However, little information is available regarding the actions
Bin Wang, Bin Wang, Aijun Cui, Aijun Cui, Yongjiang Xu, Yongjiang Xu, Yaxing Zhang, Yan Jiang, Yan Jiang, Xuezhou Liu, Xuezhou Liu   +10 more
doaj   +1 more source