Results 111 to 120 of about 713,192 (254)

FH Afrikaner-3 LDL Receptor Mutation Results in Defective LDL Receptors and Causes a Mild Form of Familial Hypercholesterolemia

, 1995
Three founder-related gene mutations (FH Afrikaner-1, -2, and -3) that affect the LDL receptor are responsible for 90% of the familial hypercholesterolemia (FH) in South African Afrikaners.
E. Langenhoven, K. Steyn, G.A. Coetzee, A.D. Marais, M.J. Kotze, D.R. van der Westhuyzen, J.F. Graadt van Roggen   +6 more
core   +1 more source

LDL-C goal achievement rates among patients with dyslipidemia (based on the 2015 Korean guidelines).

, 2020
LDL-C, low-density lipoprotein cholesterol.
Siin Kim (3949709), Yi Qian (466487), Pratik P. Rane (8378820), Sola Han (6532826), Hae Sun Suh (7249091), Zhongyun Zhao (5326046)   +5 more
core   +1 more source

A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment

Advanced Science, EarlyView.
MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu, Huixuan Xu, Li Lin, Fei Wang, Yaodong Ding, Shuangqiao Liao, Xingyu Chen, Jichen Wen, Hongqiang Zhao, Jing Hao, Weixiang Zhao, Gong Zhang, Shiguang Shan, Yong Zeng, Hu Han, Minxian Wang   +15 more
wiley   +1 more source

New lipid therapies: PCSK9 inhibitors

Journal of Clinical and Translational Endocrinology Case Reports, 2016
Pharmacologic therapy reduces cardiovascular risk in a variety of primary and secondary prevention clinical situations in addition to lifestyle modifications. Low density lipoprotein cholesterol (LDL-C) is a key mediator of atherogenesis.
Farah Meah, DO, Arshi Basit, MD, Alaleh Mazhari, DO, Mary Ann Emanuele, MD, Nicholas Emanuele, MD   +4 more
doaj   +1 more source

MRI Detection of Tumor Cells by Targeting LDL Receptors with Gd-loaded LDL Particles

, 2007
Gd-DO3A-diph and Gd-AAZTAC17 are lipophilic magnetic resonance imaging (MRI) agents that display high affinity for low-density lipoprotein (LDL) particles.
ALBERTI D, LOVAZZANO C, GENINATTI CRICH S, PAGLIARIN R, BELFIORE S, CIAMPA A, LANZARDO S, AIME S., GIOVENZANA, Giovanni Battista   +8 more
core   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Inclisiran: A New Promising Agent in the Management of Hypercholesterolemia

Diseases, 2018
The discovery of proprotein convertase subtilisin-kexin type 9 (PCSK9), a serine protease which binds to the low-density lipoprotein (LDL) receptors and targets the receptors for lysosomal degradation, offered an additional route through which plasma LDL-
Constantine E. Kosmas, Alba Muñoz Estrella, Andreas Sourlas, Delia Silverio, Elizabeth Hilario, Peter D. Montan, Eliscer Guzman   +6 more
doaj   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Ox-LDL-mediated repletion of ATP6V₀d2-KD cholesterol levels restores PV volumes and impacts parasite multiplication.

, 2019
A. Intracellular cholesterol levels displayed by nonsilenced or ATP6V0d2-KD macrophages treated or not with 50 μg/ml of ox-LDL for 48 hours, showing that ox-LDL replenishes the ~40% lower cholesterol amount of ATP6V0d2-KD to levels comparable to ...
Luiza Campos Reis (6843587), Cristina Mary Orikaza (6843593), Hiro Goto (631335), Joyce Umbelino da Silva Yamamoto (6843605), Eduardo Milton Ramos-Sanchez (6843590), Erica Valadares de Castro Levatti (6843599), Fernando Real (185142), Cristian Cortez (130519), Renato Arruda Mortara (103561), Carina Carraro Pessoa (6843584), Ana Carolina Benites Badaró (6843602), Vânia D’Almeida (135394)   +11 more
core   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source