Results 91 to 100 of about 713,192 (254)

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice

Journal of Lipid Research, 2006
In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. CETP transgenic mice and nontransgenic (nTg) littermates were studied
A.C. Casquero, J.A. Berti, A.G. Salerno, E.J.B. Bighetti, P.M. Cazita, D.F.J. Ketelhuth, M. Gidlund, H.C.F. Oliveira   +7 more
doaj   +1 more source

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]

, 2006
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Moorhead, JF, Wheeler, DC, Ruan, XZ, Varghese, Z, Ma, KL, Tao, JL, Powis, SH   +6 more
core  

Redirected targeting of LDL to human monocyte Fc gamma receptors with bispecific antibodies.

, 1992
Recent studies indicate that low density lipoprotein (LDL)-immune complexes consisting of anti-LDL antibodies bound to LDL may contribute to macrophage foam cell development by uptake through immunoglobulin G (IgG) Fc receptors.
P M Morganelli, T J Kitzmiller, M W Fanger, R Hemmer   +3 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

MC-sample1-LDL-AM

, 2017
Admixture Mapping results for LDL-cholesterol: Mexico City sample
Esteban J Parra (7852496), Parra, Esteban J   +1 more
core   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

The characterisation of the ectodomain shedding of the low density lipoprotein receptor [PDF]

, 2009
Includes abstract. Includes bibliographical references (leaves 142-155)
Parker, Ayesha
core   +1 more source

Oxidized phospholipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors

Journal of Lipid Research, 2000
Previous studies have shown that macrophage receptors for oxidized LDL (OxLDL) recognize both the lipid and protein moieties, and that a monoclonal antibody against OxLDL, EO6, also recognizes both species.
Kristin L. Gillotte, Sohvi Hörkkö, Joseph L. Witztum, Daniel Steinberg   +3 more
doaj   +1 more source

Comparison of the internalization efficiency of LDL and transferrin receptors on L2C guinea pig lymphocytes [PDF]

, 1986
We demonstrate that L2C lymphocytes have about 10-times more receptors for transferrin (TO than healthy lymphocytes, as has been shown in the case of LDL receptors. The dissociation constant is the same in the two cell types (about 4 × 10−7 M).
J.R. Philippot, Vidal, M., A. Bienvenue, Bienvenue, A., Sainte-Marie, J., M. Vidal, J. Sainte-Marie, Philippot, J.R.   +7 more
core   +1 more source