Results 11 to 20 of about 2,456,797 (213)
Large impact of low concentration oxidized LDL on angiogenic potential of human endothelial cells: a microarray study. [PDF]
PLoS ONE, 2012 Oxidized LDL (ox-LDL) is a key factor in atherogenesis. It is taken up by endothelial cells primarily by ox-LDL receptor-1 (LOX-1). To elucidate transcriptional responses, we performed microarray analysis on human coronary artery endothelial cells ...
Magomed Khaidakov +8 more
doaj +1 more source
Coaxing the LDL Receptor Family into the Fold [PDF]
Cell, 2003 Low-density-lipoprotein (LDL) receptor family members control diverse developmental and physiological pathways. In this issue of Cell, both Culi and Mann and Hsieh et al. report on Boca/MESD, a highly conserved chaperone required for transport of LDLR family proteins to the cell surface.
Joachim Herz, Peter Marschang
openaire +3 more sources
Atomistic characterization of the SiO2 high-density liquid/low-density liquid interface [PDF]
, 2022 The equilibrium silica liquid-liquid interface between the high-density liquid (HDL) phase and the low-density liquid (LDL) phase is examined using molecular-dynamics simulation. The structure, thermodynamics, and dynamics within the interfacial region are characterized in detail and compared with previous studies on the liquid-liquid phase transition (
arxiv +1 more source
Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor [PDF]
Journal of Lipid Research, 2007 LPL mediates the uptake of lipoproteins into different cell types independent of its catalytic activity. The mechanism of this process and its physiological relevance are not clear. Taking into account the importance of the endothelial barrier for lipoprotein uptake, in vitro studies with primary aortic endothelial cells from wild-type and low density ...
Martin Merkel +6 more
openaire +3 more sources
Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice.
Journal of Clinical Investigation, 2012 Individuals with type 2 diabetes have an increased risk of atherosclerosis. One factor underlying this is dyslipidemia, which in hyperinsulinemic subjects with early type 2 diabetes is typically characterized by increased VLDL secretion but normal LDL ...
Ding Ai +9 more
semanticscholar +1 more source
Thoroughly analysis of the phase diagram for the Bell-Lavis model: An entropic simulational study [PDF]
, 2020 In this work, we investigate the Bell-Lavis model using entropic simulations for several values of the energy parameters. The $T\times\mu$ phase diagram and the ground state configurations are analyzed thoroughly. Besides, we examine the particle density and specific heat behavior for different values of the chemical potential $\mu$ as functions of ...
arxiv +1 more source
Lowering plasma cholesterol by raising LDL receptors--revisited.
New England Journal of Medicine, 2012 Thirty-one years ago, Mabuchi and colleagues1 reported in the Journal that a statin called compactin reduced plasma low-density lipoprotein (LDL) cholesterol levels by 29% in patients with heterozygous familial hypercholesterolemia. This drug inhibits an
S. Young, L. Fong
semanticscholar +1 more source
Circulation Research, 2011 Rationale: Human studies and mouse models have provided evidence for angiotensin II (Ang II)–based mechanisms as an underlying cause of aneurysms localized to the ascending aorta.
D. Rateri +9 more
semanticscholar +1 more source
Journal of Clinical Investigation, 2006 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K subfamily of subtilases that reduces the number of LDL receptors (LDLRs) in liver through an undefined posttranscriptional mechanism.
Thomas A. Lagace +10 more
semanticscholar +1 more source
PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain
Journal of Lipid Research, 2010 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates hepatic low-density lipoprotein receptor (LDLR) levels in humans.
Mali Liu +12 more
semanticscholar +1 more source