Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders. [PDF]
, 2016 Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and cardiovascular disease.
Mahley, Robert W
core +1 more source
Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]
, 2006 Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL +6 more
core +1 more source
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function [PDF]
Human Molecular Genetics, 2013 A common synonymous single nucleotide polymorphism in exon 12 of the low-density lipoprotein receptor (LDLR) gene, rs688, has been associated with increased plasma total and LDL cholesterol in several populations. Using immortalized lymphoblastoid cell lines from a healthy study population, we confirmed an earlier report that the minor allele of rs688 ...
Gao, Feng +3 more
openaire +5 more sources
An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]
, 2018 Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances +2 more
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Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein
Nature Communications, 2018 Vesicular stomatitis virus (VSV) is an oncolytic rhabdovirus and its glycoprotein G is widely used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV. Here we report two crystal
Jovan Nikolic +5 more
semanticscholar +1 more source
Coaxing the LDL Receptor Family into the Fold [PDF]
Cell, 2003 Low-density-lipoprotein (LDL) receptor family members control diverse developmental and physiological pathways. In this issue of Cell, both Culi and Mann and Hsieh et al. report on Boca/MESD, a highly conserved chaperone required for transport of LDLR family proteins to the cell surface.
Joachim Herz, Peter Marschang
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Atomistic characterization of the SiO2 high-density liquid/low-density liquid interface [PDF]
, 2022 The equilibrium silica liquid-liquid interface between the high-density liquid (HDL) phase and the low-density liquid (LDL) phase is examined using molecular-dynamics simulation. The structure, thermodynamics, and dynamics within the interfacial region are characterized in detail and compared with previous studies on the liquid-liquid phase transition (
arxiv +1 more source
Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor [PDF]
Journal of Lipid Research, 2007 LPL mediates the uptake of lipoproteins into different cell types independent of its catalytic activity. The mechanism of this process and its physiological relevance are not clear. Taking into account the importance of the endothelial barrier for lipoprotein uptake, in vitro studies with primary aortic endothelial cells from wild-type and low density ...
Martin Merkel +6 more
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Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice.
Journal of Clinical Investigation, 2012 Individuals with type 2 diabetes have an increased risk of atherosclerosis. One factor underlying this is dyslipidemia, which in hyperinsulinemic subjects with early type 2 diabetes is typically characterized by increased VLDL secretion but normal LDL ...
Ding Ai +9 more
semanticscholar +1 more source
Thoroughly analysis of the phase diagram for the Bell-Lavis model: An entropic simulational study [PDF]
, 2020 In this work, we investigate the Bell-Lavis model using entropic simulations for several values of the energy parameters. The $T\times\mu$ phase diagram and the ground state configurations are analyzed thoroughly. Besides, we examine the particle density and specific heat behavior for different values of the chemical potential $\mu$ as functions of ...
arxiv +1 more source