Results 191 to 200 of about 713,192 (254)

Epigenetic Predictors of Smoking: External Validation and Association With Smoking‐Related Cancer Risk

International Journal of Cancer, EarlyView.
ABSTRACT Tobacco smoking has a strong influence on DNA methylation (DNAm), enabling the development of DNAm‐based smoking predictors, yet external evaluations of these have remained limited. We aimed to assess six DNAm‐based smoking predictors in a large sample of middle‐aged and older Australians for (i) their accuracy and reliability, and (ii) their ...
Xiaoyu Fan, Danmeng Lily Li, Allison M. Hodge, Julie K. Bassett, Nina Afshar, Melissa C. Southey, Graham G. Giles, Roger L. Milne, Pierre‐Antoine Dugué   +8 more
wiley   +1 more source

Hypertriglyceridaemia and its multifaceted mechanisms driving atherosclerotic cardiovascular disease​​. [PDF]

Lipids Health Dis
Li X, Xu L, Li J, Luo Y, Shen H, Zhang D.   +5 more
europepmc   +1 more source

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Integrated approach to menopausal hormone therapy in women with cardiovascular risk factors or established ischemic heart disease, from early treatment initiation and risk stratification to individualized therapy, multidisciplinary follow‐up, and health‐system recommendations.
Chiara Benedetto, Martha Gulati, Suvarna S. Khadilkar, Angela H. E. M. Maas, Federica Frezet, Gláucia Maria Moraes de Oliveira, Andrea R. Genazzani, Hema Divakar, Athena Poppas, on behalf of the World Heart Federation (WHF) and the International Federation of Gynecology and Obstetrics (FIGO)   +9 more
wiley   +1 more source

IL-6 triggers lysosomal degradation of LDL-R and enhances LDL-C uptake in vascular endothelial cells via macropinocytosis. [PDF]

Mol Med
Zegeye MM, Veettil JT, Paramel GV, Kurt S, Salihovic S, Ljungberg LU, Kumawat AK, Sirsjö A.   +7 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Regulation of PCSK9 During Oxidized LDL-Induced Foam Cell Formation in RAW264.7 Cells. [PDF]

Biology (Basel)
Howlader MSI, Das M, Hansda S, Siraj MA, Das H.   +4 more
europepmc   +1 more source

Gut Enterococcus faecium derived leucic acid mediates the antiobesity effect of dietary fiber

iMeta, EarlyView.
This study identified Enterococcus faecium as a gut bacterium with anti‐obesity activity, which alleviated adipocyte hypertrophy, dyslipidemia, and hepatic steatosis by converting leucine into leucic acid (LEA) to regulate mitochondrial oxidative phosphorylation.
Baifei Hu, Qianru Gao, Junmin Hui, Mengqiong Wang, Haiyan Gao, Kai Li, Junping Zheng, Zhe Dai, Songlin Liu, Hongtao Liu   +9 more
wiley   +1 more source

Familial Hypercholesterolemia. [PDF]

Methodist Debakey Cardiovasc J
Iatan I, Genest J.
europepmc   +1 more source

TRIM31–LOX‐1 Axis: A Novel Therapeutic Frontier in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis, driven by a vicious cycle of lipid accumulation and chronic inflammation, underlies most cardiovascular diseases. Macrophages exacerbate this process by internalizing oxidized low‐density lipoprotein (oxLDL), forming foam cells, and releasing inflammatory mediators. A recent study published in Circulation identified the TRIM31–
Qian Zhang, Cheng Xue Qin
wiley   +1 more source

PCSK9 inhibitors in neurodegenerative disorders: mechanisms, therapeutic potential, and clinical implications. [PDF]

Transl Neurodegener
Wang JDJ, Teo AYT, Xiao B, Chao Y, Zhou ZD, Tan BJ, Chan LL, Rosalie E, Tan EK.   +8 more
europepmc   +1 more source