Results 201 to 210 of about 713,192 (254)

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

A Novel Triglyceride- and Cholesterol-Enriched Lipoprotein(a) Phenotype in Moderate Hypertriglyceridemia: Reversal by ApoC-III Inhibition. [PDF]

JACC Basic Transl Sci
Lin L, Brush MN, Nelson CB, Alexander VJ, Xia S, Gordts PLSM, Tsimikas S.   +6 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Proteomic Analysis of Sphingolipid Metabolic Enzymes with Risk of Bladder Cancer Incidence and Mortality in the Atherosclerosis Risk in Communities Study. [PDF]

Cancer Prev Res (Phila)
Marrone MT, Bagley E, Butler KR, Couper DJ, Joshu CE, Platz EA, Ogretmen B.   +6 more
europepmc   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

The N-terminus of apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells. [PDF]

J Clin Invest
Cabodevilla AG, Calistru C, Younis W, Nasias D, Ho TW, Anaganti N, Valmiki S, Rajan S, Gjini J, Kore R, Hannemann C, Davidson NO, Vaisar T, Kanter JE, Bornfeldt KE, Fisher EA, Lee WL, Madl T, Hussain MM, Goldberg IJ.   +19 more
europepmc   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Dietary Bioactive Compounds: Cellular Sensory Pathways, Microbial Partners, and Clinical Realities. [PDF]

Nutrients
Dos Santos EA, Alvarez-Leite JI.
europepmc   +1 more source

Machine Learning–Based Comparative Analysis of Blood Cell–Derived Inflammatory Indices for Predicting MAFLD and Liver Fibrosis: Evidence From NHANES 2017–2020

Journal of Clinical Laboratory Analysis, EarlyView.
This research assesses the correlations and diagnostic efficacy of blood cell‐derived inflammatory indicators in predicting metabolic dysfunction‐associated fatty liver disease (MAFLD) and liver fibrosis using NHANES 2017–2020 data. AISI had the highest predictive capability for MAFLD, while PLR served as the most efficacious indicator for fibrosis ...
Hao Chen, Qinmei Chen, Xiangqian Wang, Yixian He, Xiqiao Zhou   +4 more
wiley   +1 more source

Abetalipoproteinemia With a Novel Microsomal Triglyceride Transfer Protein Gene Mutation and Unique Oxidized Lipoprotein Levels. [PDF]

J Med Cases
Hamasaki M, Hara K, Kotani K.
europepmc   +1 more source