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Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm
Atherosclerosis, 2000The level of LDL in plasma is the major determinantof the risk of vascular disease and lowering the level ofLDL diminishes that risk, both in those with and thosewithout symptomatic vascular disease [1–4]. Fully un-derstanding the factors that govern the concentration ofplasma LDL is, therefore, one of our most importantchallenges.
Allan D. Sniderman +2 more
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Cholesterol in LDL receptor recycling and degradation
Clinica Chimica Acta, 2020The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum (ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol response element binding protein 2 (SREBP2), pro-protein convertase subtilisin/kexin type 9 (PCSK9) and inducible degrader of LDLR (IDOL).
Hui-xian Yang +7 more
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New lipid-lowering agents acting on LDL receptors.
Current Topics in Medicinal Chemistry, 2005The treatment of dyslipoproteinemia has proven a successful strategy in the prevention of cardiovascular diseases. The major target of hypolipidemic drugs is the reduction of low density lipoprotein cholesterol (LDL-C).
H. Scharnagl, W. März
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Diverse roles for the LDL receptor family
Trends in Endocrinology & Metabolism, 2002The low-density lipoprotein (LDL) receptor family consists of several related scavenger receptors that not only function as important cargo transporters, but also inform the cell of changes in its environment by mediating signaling responses. The LDL receptor was the first family member to be characterized and its function seems to be restricted to ...
Steven L. Gonias +2 more
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LDL Receptor‐Related Proteins in Neurodevelopment
Traffic, 2003Low‐density lipoprotein receptor‐related proteins (LRPs) are evolutionarily ancient cell‐surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment.
Joachim Herz, Petra May
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Regulation of LDL Receptors in vivo
1984The information reviewed here indicates that LDL receptor activity in vivo is regulated in normal animals and probably in normal humans. Furthermore, LDL receptor activity is also regulated in patients with heterozygous Familial Hypercholesterolemia. Our experiments in patients with this disease indicate that one can exploit the normal regulation of ...
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Differences in Receptor Binding of LDL Subfractions
Arteriosclerosis, Thrombosis, and Vascular Biology, 1996AbstractDifferences in low density lipoprotein (LDL) receptor-binding affinity among LDL particles of different size were examined in competitive binding assays in human skin fibroblasts and LDL (d=1.020 to 1.050 g/mL) from subjects with a predominance of large (≥272 Å), medium (259 to 271 Å), and small (≤257 Å) LDL. Among 57 normolipidemic subjects
Ronald M. Krauss +4 more
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Activation of EGF receptor by oxidized LDL
The FASEB Journal, 1998Oxidized low density lipoproteins (oxLDL) are thought to play a major role in atherosclerosis. OxLDL exhibit a wide variety of biological effects resulting from their ability to interfere with intracellular signaling. The cellular targets and primary signaling events of oxLDL are unknown.
Jean Vandaele +6 more
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The Role of the LDL Receptor in Lipoprotein Metabolism
1987The discovery of the LDL receptor in cultured mammalian cells by Goldstein and Brown in 1973 was followed by a rapid increase in our understanding of cellular and total body cholesterol metabolism1. The LDL receptor is the starting point for an intracellular pathway which is of fundamental importance in regulating cellular cholesterol metabolism ...
David W. Bilheimer, Scott M. Grundy
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The LDL Receptor — Structural Insights [PDF]
, 1986 Low density lipoprotein (LDL), the major cholesterol-carrying class of lipopro-teins in human plasma, is taken up by hepatic and extrahepatic cells via receptor-mediated endocytosis. In this process, LDL particles bind to cell-surface receptors, the LDL receptors, which are localized in specialized regions of the plasma membrane called coated pits ...
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