Results 251 to 260 of about 122,014 (288)

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches

PROTEOMICS, EarlyView.
Paul Perco, Matthias Ley, Kinga Kęska‐Izworska, Dorota Wojenska, Enrico Bono, Samuel M. Walter, Lucas Fillinger, Klaus Kratochwill   +7 more
wiley   +1 more source

Lowering LDL cholesterol, but not raising LDL receptor activity, by ezetimibe [PDF]

Journal of Clinical Lipidology, 2013
Ezetimibe, an inhibitor of intestinal cholesterol absorption, is effective in lowering serum low-density lipoprotein (LDL) cholesterol with or without coadministration of statin. Ezetimibe-plus-statin therapy enhances LDL receptor activity, but it is still unclear whether ezetimibe alone enhances LDL receptor activity, resulting in LDL cholesterol ...
Mitsunobu Kawamura, Hiroshi Hayashi
openaire   +2 more sources

LDL Receptor's β-Propeller Displaces LDL [PDF]

Science, 2002
The low density lipoprotein receptor (LDLR) binds to lipoprotein extracellularly and releases it in the endosome. In his Perspective, Innerarity discusses new structural work (Rudenkoet al.) that shows that an interdomain interaction that occurs at low pH likely displaces ligand from the receptor in the endosome.
openaire   +1 more source

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[36] Purification of the LDL receptor

1985
Publisher Summary This chapter describes the methods for the purification of the low-density lipoprotein (LDL) receptor from various sources. These methods are designed to enable researchers to obtain chemical amounts of purified receptor from a rich source—the adrenal cortex—and smaller amounts of radiolabeled LDL receptors from less abundant ...
Wolfgang J. Schneider, Joseph L. Goldstein, Michael S. Brown   +2 more
openaire   +3 more sources

Identification of a lipolysis-stimulated receptor that is distinct from the LDL receptor and the LDL receptor-related protein

Biochemistry, 1994
This paper provides further characterization of a receptor that, in cells lacking the LDL receptor (FH fibroblasts), mediates lipoprotein binding, uptake, and degradation when incubated with oleate at concentrations not exceeding albumin binding capacity.
Nabil F. Hannouche, Conrad A. Hornick, Genevieve Agnani, Lydie M. Guermani, Noella Hubert, Bernard Bihain, Valerie N. Bordeau, Christopher J. Mann, Frances T. Yen   +8 more
openaire   +2 more sources

The VLDL receptor: wayward brother of the LDL receptor

Current Opinion in Lipidology, 1995
The VLDL receptor binds lipoproteins that contain apolipoprotein E and consists of five functional domains that resemble the LDL receptor. Although the LDL- and VLDL-receptor genes are located on different chromosomes, their gene structure and organization are almost the same.
Hisato Jingami, Tokuo Yamamoto
openaire   +3 more sources

Solution Structure of the Sixth LDL-A Module of the LDL Receptor^,

Biochemistry, 2000
The low-density lipoprotein receptor (LDLR) is the primary mechanism for uptake of plasma cholesterol into cells and serves as a prototype for an entire class of cell surface receptors. The amino-terminal domain of the receptor consists of seven LDL-A modules; the third through the seventh modules all contribute to the binding of low-density ...
Stephen C. Blacklow, Christopher L. North   +1 more
openaire   +3 more sources

LDL receptor polymorphisms revisited

Blood, 2010
In this issue of Blood , Martinelli and colleagues describe that certain single-nucleotide polymorphisms in the LDL receptor gene independently associate with high plasma levels of coagulation factor VIII in patients with coronary artery disease.[1][1] In 1985, Drs M. S. Brown and J.
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Expression of LDL receptor and uptake of LDL in mouse preimplantation embryos

Molecular and Cellular Endocrinology, 2003
The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos.The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched blastocyst stage were analyzed by RT-PCR and nested PCR ...
Yoko Honda, Naoki Sato, Jun Fukuda, Toshiharu Sato, Hideo Tanikawa, Hideya Kodama, Kazuhiro Kawamura, Toshinobu Tanaka   +7 more
openaire   +3 more sources