Results 261 to 270 of about 122,014 (288)
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1998
Recently we described the specific inhibitory action of lactoferrin on chylomicron remnant (CR) uptake into the intact rat liver. Injection of lactoferrin but not transferrin (7 mg/100 g animal weight) together with radiolabelled CR inhibits in vivo uptake into liver by 50%. No inhibition of uptake into spleen was observed1.
Hans Lassmann +3 more
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Recently we described the specific inhibitory action of lactoferrin on chylomicron remnant (CR) uptake into the intact rat liver. Injection of lactoferrin but not transferrin (7 mg/100 g animal weight) together with radiolabelled CR inhibits in vivo uptake into liver by 50%. No inhibition of uptake into spleen was observed1.
Hans Lassmann +3 more
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Finally, the LDL receptor joins in [PDF]
Blood, 2005 Comment on Bovenschen et al, page [906][1] The LDL receptor is a member of a family of gene products with partially overlapping function. In this issue of Blood , Bovenschen and colleagues describe how members of the LDL receptor gene family cooperate in the regulation of factor VIII.
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Bypassing the LDL Receptor in Familial Hypercholesterolemia
New England Journal of Medicine, 2020Several drug options are available for patients with an elevated plasma cholesterol level who are at increased risk for a cardiovascular event.
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Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm
Atherosclerosis, 2000The level of LDL in plasma is the major determinantof the risk of vascular disease and lowering the level ofLDL diminishes that risk, both in those with and thosewithout symptomatic vascular disease [1–4]. Fully un-derstanding the factors that govern the concentration ofplasma LDL is, therefore, one of our most importantchallenges.
Allan D. Sniderman +2 more
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Cholesterol in LDL receptor recycling and degradation
Clinica Chimica Acta, 2020The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum (ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol response element binding protein 2 (SREBP2), pro-protein convertase subtilisin/kexin type 9 (PCSK9) and inducible degrader of LDLR (IDOL).
Hui-xian Yang +7 more
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Diverse roles for the LDL receptor family
Trends in Endocrinology & Metabolism, 2002The low-density lipoprotein (LDL) receptor family consists of several related scavenger receptors that not only function as important cargo transporters, but also inform the cell of changes in its environment by mediating signaling responses. The LDL receptor was the first family member to be characterized and its function seems to be restricted to ...
Steven L. Gonias +2 more
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LDL Receptor‐Related Proteins in Neurodevelopment
Traffic, 2003Low‐density lipoprotein receptor‐related proteins (LRPs) are evolutionarily ancient cell‐surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment.
Joachim Herz, Petra May
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Regulation of LDL Receptors in vivo
1984The information reviewed here indicates that LDL receptor activity in vivo is regulated in normal animals and probably in normal humans. Furthermore, LDL receptor activity is also regulated in patients with heterozygous Familial Hypercholesterolemia. Our experiments in patients with this disease indicate that one can exploit the normal regulation of ...
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Scavenger Receptors, Oxidized LDL, and Atherosclerosis
Annals of the New York Academy of Sciences, 2001Abstract: Oxidized LDL (OxLDL) competes with oxidatively damaged and apoptotic cells for binding to mouse peritoneal macrophages, implying the presence of one or more common domains. However, the nature of the ligands involved has not been determined.
Joseph L. Witztum +12 more
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Differences in Receptor Binding of LDL Subfractions
Arteriosclerosis, Thrombosis, and Vascular Biology, 1996AbstractDifferences in low density lipoprotein (LDL) receptor-binding affinity among LDL particles of different size were examined in competitive binding assays in human skin fibroblasts and LDL (d=1.020 to 1.050 g/mL) from subjects with a predominance of large (≥272 Å), medium (259 to 271 Å), and small (≤257 Å) LDL. Among 57 normolipidemic subjects
Ronald M. Krauss +4 more
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