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The Role of the LDL Receptor in Lipoprotein Metabolism
1987The discovery of the LDL receptor in cultured mammalian cells by Goldstein and Brown in 1973 was followed by a rapid increase in our understanding of cellular and total body cholesterol metabolism1. The LDL receptor is the starting point for an intracellular pathway which is of fundamental importance in regulating cellular cholesterol metabolism ...
David W. Bilheimer, Scott M. Grundy
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Activation of EGF receptor by oxidized LDL
The FASEB Journal, 1998Oxidized low density lipoproteins (oxLDL) are thought to play a major role in atherosclerosis. OxLDL exhibit a wide variety of biological effects resulting from their ability to interfere with intracellular signaling. The cellular targets and primary signaling events of oxLDL are unknown.
Jean Vandaele +6 more
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The LDL Receptor — Structural Insights [PDF]
, 1986 Low density lipoprotein (LDL), the major cholesterol-carrying class of lipopro-teins in human plasma, is taken up by hepatic and extrahepatic cells via receptor-mediated endocytosis. In this process, LDL particles bind to cell-surface receptors, the LDL receptors, which are localized in specialized regions of the plasma membrane called coated pits ...
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Determination of LDL Receptors on Cultured Lymphocytes Using Fluorescein-Labeled LDL
American Journal of Clinical Pathology, 1982A rapid, sensitive procedure for the detection of LDL receptors on cell surface without using radioisotopes is described. Fluorescein-isothiocyanate (FITC) labeled LDL bound with cultured human lymphocytes, and the degree of that binding was compatible with that of 125 I-labeled LDL.
Masayuki Endoh +2 more
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Low density lipoprotein (LDL) binding affinity for the LDL receptor in hyperlipoproteinemia
Atherosclerosis, 1999We measured the binding affinity of low density lipoprotein (LDL) for the LDL receptor in patients with various types of hyperlipoproteinemia and investigated the effects of LDL lipid composition and particle size on receptor affinity. LDL (1.019 < d < 1.063) was isolated by sequential ultracentrifugation from the serum of normolipidemic controls and ...
Taku Yamamura +3 more
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Isolation and assay of the Ac-LDL receptor
1986Publisher Summary This chapter discusses various isolation and assay of the Ac-LDL receptor. To effectively study the scavenger cell pathway receptor, one needs a convenient source of receptor, a means for purification of the receptor, and methods for assay of receptor function.
David P. Via +2 more
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Cholesterol Homeostasis: Role of the LDL Receptor
The FASEB Journal, 1995age, and its metabolism to bile acids, their interests would represent only a small fraction of the overall attention that has been given to this sterol. The major focus on cholesterol by both the medical research community and the lay public is because it is the central feature of two major afflictions, atherosclerosis and gallstones.
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Familial hypercholesterolaemia and LDL receptor mutations
Journal of Internal Medicine, 1992Abstract. Inherited defects in the gene for the low density lipoprotein (LDL)‐receptor give rise to familial hypercholesterolaemia (FH), a disorder in which defective catabolism of LDL causes a marked increase in its concentration in plasma. As a result, there is excessive deposition of cholesterol in the arterial wall leading to accelerated ...
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1997
Summary The LDL receptor's structure and function at the cellular level has been well characterized mostly by the work of Goldstein, Brown, and co-workers. A large number of mutations of the LDL receptor gene has been reported worldwide and their clinical relevance to the severity of familial hypercholesterolemia evaluated.
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Summary The LDL receptor's structure and function at the cellular level has been well characterized mostly by the work of Goldstein, Brown, and co-workers. A large number of mutations of the LDL receptor gene has been reported worldwide and their clinical relevance to the severity of familial hypercholesterolemia evaluated.
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