Results 51 to 60 of about 126,252 (290)
Advanced Healthcare Materials, EarlyView.AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan +3 more
wiley +1 more source
Journal of Lipid Research, 1996 The oxidative modification of low density lipoproteins (LDL) by arterial wall cells is thought to contribute to atherogenesis. Monocyte/macrophages, among other arterial wall cells, oxidatively modify LDL to a form that is recognized by scavenger ...
R K Tangirala, M J Mol, D Steinberg
doaj
Oxidized LDL triggers pro-oncogenic signaling in human breast mammary epithelial cells partly via stimulation of MiR-21. [PDF]
PLoS ONE, 2012 Dyslipidemia and obesity are primary risk factors for the development of atherosclerosis and are also epidemiologically linked to increased susceptibility to a variety of cancers including breast cancer.
Magomed Khaidakov, Jawahar L Mehta
doaj +1 more source
LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]
, 2010 Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Al-Allaf, FA +5 more
core +3 more sources
Advanced Materials, EarlyView.This work has developed a dual enzyme‐mimicking and ultrasound‐responsive Nb2C‐Pt@HA‐PEG nanozyme. ROS‐eliminating and antiinflammatory capability of Nb2C‐Pt@HA‐PEG under US irradiation are demonstrated on macrophages and endothelial cells in vitro. Nb2C‐Pt@HA‐PEG‐mediated sonocatalytic therapy exerts an outstanding anti‐atherosclerosis efficacy by ...
Qianqian Bai +6 more
wiley +1 more source
Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice [PDF]
Journal of Lipid Research, 2001 The low density lipoprotein receptor (LDLR) plays a major role in regulation of plasma cholesterol levels as a ligand for apolipoprotein B-100 and apolipoprotein E (apoE). Consequently, LDLR-deficient mice fed a Western-type diet develop significant hypercholesterolemia and atherosclerosis.
Masa-aki Kawashiri +5 more
openaire +4 more sources
MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. [PDF]
, 2014 Low-grade systemic inflammation is often associated with metabolic syndrome, which plays a critical role in the development of the obesity-associated inflammatory diseases, including insulin resistance and atherosclerosis.
DeFranco, Anthony L +19 more
core +2 more sources
Advanced Materials, EarlyView.The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng +19 more
wiley +1 more source
Frontiers in Veterinary Science, 2019 Altered lipid metabolism is a well-documented hallmark of neoplastic transformation and impacts disease progression. Two major lipoprotein receptors, the low-density lipoprotein receptor (LDL-R) and scavenger receptor class B, type 1 (SR-BI) are ...
Kristina Ceres +4 more
doaj +1 more source
The anti-atherogenic effects of thiazolidinediones [PDF]
, 2007 The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced
Honisett, Suzy +2 more
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