Results 51 to 60 of about 122,014 (288)
Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]
, 1999 The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Amatruda TT +28 more
core +1 more source
Advanced Science, EarlyView.This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu +11 more
wiley +1 more source
Journal of Lipid Research, 1996 The oxidative modification of low density lipoproteins (LDL) by arterial wall cells is thought to contribute to atherogenesis. Monocyte/macrophages, among other arterial wall cells, oxidatively modify LDL to a form that is recognized by scavenger ...
R K Tangirala, M J Mol, D Steinberg
doaj
Oxidized LDL triggers pro-oncogenic signaling in human breast mammary epithelial cells partly via stimulation of MiR-21. [PDF]
PLoS ONE, 2012 Dyslipidemia and obesity are primary risk factors for the development of atherosclerosis and are also epidemiologically linked to increased susceptibility to a variety of cancers including breast cancer.
Magomed Khaidakov, Jawahar L Mehta
doaj +1 more source
TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death [PDF]
, 2019 Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97).
Hawkins, William G. +9 more
core +3 more sources
Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice [PDF]
Journal of Lipid Research, 2001 The low density lipoprotein receptor (LDLR) plays a major role in regulation of plasma cholesterol levels as a ligand for apolipoprotein B-100 and apolipoprotein E (apoE). Consequently, LDLR-deficient mice fed a Western-type diet develop significant hypercholesterolemia and atherosclerosis.
Masa-aki Kawashiri +5 more
openaire +4 more sources
Advanced Science, EarlyView.Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu +13 more
wiley +1 more source
Angewandte Chemie, EarlyView.A novel polarity‐sensitive fluorescent probe was developed for the selective targeting of lipid droplets, enabling precise visualization and quantification of lipid metabolism disorders using an integrated STED‐FLIM platform. This probe allows accurate monitoring of lipid metabolism in cellular and pathological contexts, such as atherosclerosis ...
Shixian Cao +7 more
wiley +2 more sources
LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]
, 2010 Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Al-Allaf, FA +5 more
core +3 more sources
Advanced Science, EarlyView.In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains health at a cellular level, 1,25(OH)2D3, and ameliorates the decline in the vitamin D status marker 25(OH)D.
Oliver J. Perkin +11 more
wiley +1 more source