Results 141 to 150 of about 90,104 (295)

Relationship between adipose tissue dysfunction, Vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease [PDF]

, 2017
Non-alcoholic fatty liver disease ( NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood.
BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CAROTTI, Simone, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, Morini, Sergio, VESPASIANI GENTILUCCI, UMBERTO   +7 more
core   +1 more source

The Efficacy of Pharmacological Treatment of Depression in Anorexia Nervosa and Underweight Patients: A Systematic Review

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Major depressive disorder (MDD) is a frequent comorbidity in anorexia nervosa (AN). This review aimed to evaluate evidence on the effectiveness of pharmacological treatments for MDD in underweight individuals. Method A systematic review was conducted using PubMed, Medline, PsycINFO, and Web of Science through March 2025.
M. J. Besjes, S. H. W. Mares, A. A. van Elburg, J. Spijker   +3 more
wiley   +1 more source

GDF15 Is Elevated in Eating Disorders and Is Involved in the Gut‐Brain Axis via Ghrelin

European Eating Disorders Review, EarlyView.
ABSTRACT Objective GDF15 induces anorexia and visceral discomfort, regulating appetite, food intake and potentially metabolic responses. However, its role in eating disorders remains unexplored. Method A total of 145 participants were recruited (60 patients with anorexia nervosa, 20 with bulimia nervosa, 13 with binge eating disorder, 52 participants ...
Livio Tarchi, Giulia Brancolini, Sara Giachetti, Gaia Maiolini, Emanuele Cassioli, Eleonora Rossi, Gianluca Villa, Rachele Garella, Roberta Squecco, Paolo Rovero, Paolo Comeglio, Valdo Ricca, Francesco De Logu, Romina Nassini, Giovanni Castellini   +14 more
wiley   +1 more source

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? [PDF]

, 2017
Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological ...
Agra, Agra, Alexander, Alexander, Alexander, Alexopoulos, Arora, Baessler, Bakkum, Balcioglu, Berridge, Berry, Bers, Bers, Bełtowski, Bian, Burgeiro, Burridge, Castro, Chechi, Cheng, Chilukoti, Chiu, Daya, Dekker, Deng, Deng, Dobrzynski, Dong, Du, Eisner, Elie, Elisha, Engler, Fain, Fandino-Vaquero, Fernandez-Trasancos, Fosshaug, Frankel, Furuhashi, Gaborit, Gaborit, Gao, Georgiou, Ghantous, Gho, Goncalves, Greif, Greulich, Greulich, Greulich, Gruen, Guauque-Olarte, Haemers, Harada, Hassan, Hatem, Hatem, Hatem, Heijman, Heijman, Hua, Hung, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Imoto-Tsubakimoto, Iozzo, Itoh, Janik, Karastergiou, Kaushik, Kazumi, Kim, Kim, Kitagawa, Kleinz, Kusayama, Lage, Lamounier-Zepter, Lamounier-Zepter, Langheim, Leeper, Li, Lim, Lip, Look, MacQueen, Maghbooli, Mahabadi, Mahabadi, Marchington, Marchington, Margaritis, Martinsen, Matloch, Mattacks, Mattacks, Mattacks, Mazurek, Mazurek, Mazzoccoli, McAninch, Mookadam, Nakanishi, Nevelsteen, Nicholls, O'Connell, Pang, Paolisso, Parisi, Pezeshkian, Phillips, Pierdomenico, Pond, Pontes Soares, Prati, Rabkin, Rachwalik, Rainwater, Rajapurohitam, Rodriguez-Penas, Sacks, Sacks, Sacks, Sade, Salgado-Somoza, Samanta, Sarin, Scimia, Shapira-Schweitzer, Shibasaki, Shimabukuro, Siegel-Axel, Silaghi, Smith, Song do, Southan, Spiroglou, Szokodi, Takebayashi, Talman, Teijeira-Fernandez, Vacca, Venteclef, Viscogliosi, Voigt, Vural, Weikert, Westcott, White, Willens, Wong, Xu, Yamaguchi, Yañez-Rivera, Ye, Yilmaz, Zdychova, Zeng, Zhou   +164 more
core   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Receptor-Mediated Transcytosis of Leptin through Human Intestinal Cells In Vitro

International Journal of Cell Biology, 2010
Gastric Leptin is absorbed by duodenal enterocytes and released on the basolateral side towards the bloodstream. We investigated in vitro some of the mechanisms of this transport.
Philippe G. Cammisotto, Moise Bendayan, Alain Sané, Michel Dominguez, Carole Garofalo, Émile Levy   +5 more
doaj   +1 more source

Oat Bran Supplementation Improves Glucose Metabolism, Food Addiction, and Gut Microbiota in Rats With High‐Fat Diet‐Induced Obesity

Food Frontiers, EarlyView.
ABSTRACT Oat bran (OB), a byproduct of the oat milling process, is a nutrient‐dense cereal cultivated in cool, dry mountainous regions and is known for its potential health benefits. To explore its obesity‐alleviating effects and the underlying mechanisms, we examined the influence of OB on glucose metabolism, appetite‐regulating hormones, gut ...
Xue Bai, Meili Zhang, Yakun Zhang, Yuanyuan Zhang, Rui Huo, Qixin Gu, Ying Miao   +6 more
wiley   +1 more source

Bioactive polysaccharides and their potential health benefits in reducing the risks of metabolic syndrome: A review

Food Biomacromolecules, EarlyView.
Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo, Evelyne Nkirote Gikundi, Mercy Adhiambo Ndiege, Kevin Omondi Aduol   +3 more
wiley   +1 more source

The complex interactions between obesity, metabolism and the brain [PDF]

, 2019
Obesity is increasing at unprecedented levels globally, and the overall impact ofobesity on the various organ systems of the body is only beginning to be fullyappreciated. Because of the myriad of direct and indirect effects of obesity causingdysfunction
Keller, Jeffrey Neil, Uranga, Romina Maria   +1 more
core   +1 more source

The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors

Journal of Obesity, 2012
Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight.
Fabio Panariello, Gina Polsinelli, Carol Borlido, Marcellino Monda, Vincenzo De Luca   +4 more
doaj   +1 more source