Results 181 to 190 of about 90,104 (295)

Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey. [PDF]

Mol Biol Evol
Gong N, Barany A, Norstog JL, Larhammar D, Björnsson BT, Regish AM, McCormick SD, Sheridan MA.   +7 more
europepmc   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Adipokines in preeclampsia: disrupted signaling pathways and novel therapeutic strategies. [PDF]

Eur J Med Res
Abdalla RAH, Parveen N, Iqbal N, Mohamed AAA, Shahid SMA, Elhussein GEMO, Saleem M, Khan MS.   +7 more
europepmc   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

G proteins of the G₁₂ family expressed by POMC neurons regulate key metabolic functions. [PDF]

Sci Adv
Haspula D, Cui Z, Pittala S, Cui Y, Lu H, Xiong Y, Jin J, Gavrilova O, Hwang E, Ajwani J, Portillo B, Williams KW, Inoue A, Wess J.   +13 more
europepmc   +1 more source

Genetic variants linked to statin‐associated Type 2 diabetes mellitus: Findings from the UK Biobank and the All of Us Research Program

British Journal of Pharmacology, EarlyView.
Background and Purpose Statins are widely prescribed for the prevention of cardiovascular disease, yet recent studies suggest an increased risk of new‐onset Type 2 diabetes mellitus. This study aimed to identify genetic variants associated with statin‐associated new‐onset Type 2 diabetes mellitus from the UK Biobank and All of Us.
Yoon‐A Park, Da Hoon Lee, Jung Sun Kim, Jeong Yee, Hye Sun Gwak   +4 more
wiley   +1 more source

The central signaling pathways related to metabolism-regulating hormones of the gut-brain axis: a review. [PDF]

J Transl Med
Liu J, Jing C, Guo Y, Shang Z, Zhang B, Zhou X, Zhang J, Lian G, Tian F, Li L, Chen Y.   +10 more
europepmc   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, EarlyView.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

The Integrated Function of the Lateral Hypothalamus in Energy Homeostasis. [PDF]

Cells
Chen X, Wang Y, Fu S, Wan Y, Mao J, Cui K, Jiang H.   +6 more
europepmc   +1 more source

Clinical Significance of Skeletal Fat‐to‐Muscle Ratio in Idiopathic Hyperaldosteronism

Clinical Endocrinology, EarlyView.
ABSTRACT Objective The objective of this study is to evaluate the correlation between the fat‐to‐muscle ratio (FMR) and insulin resistance (IR) with aldosterone production among patients with idiopathic hyperaldosteronism (IHA). Methods Patients with primary aldosteronism were screened from those with secondary hypertension and then subtyped via ...
Yuhe Jiang, Dan Li, Cassie Chen Cao, Wenjing Feng, Ruidong Liu, Yinfei Xu, Caixia Cao   +6 more
wiley   +1 more source