Results 231 to 240 of about 2,667,642 (350)

Advances in Small Molecule Inhibitors Targeting the Bacterial Lipoprotein Transport System (Lol) in Gram‐Negative Bacteria

Chemistry – An Asian Journal, EarlyView.
The lipoprotein transport system (Lol) is a crucial target for combating multidrug‐resistant gram‐negative bacteria. This review discusses the structural and functional aspects of the LolABCDE complex, recent advances in small‐molecule inhibitors, and challenges, such as permeability and resistance.
Saemee Song, Su Yong Shim
wiley   +1 more source

Innate extracellular mouse Hsp70 inflammatory properties are mediated by the interaction of Siglec-E and LOX-1 receptors. [PDF]

Cell Stress Chaperones
Borges TJ, Lima K, Murshid A, Lape IT, Rigo MM, Lang BJ, Teani TJ, Siddiqui SS, Riella LV, Bonorino C, Calderwood SK.   +10 more
europepmc   +1 more source

LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice [PDF]

, 2018
Jeong, Lak Shin, Jeong, Se-Jin, Kim, Gyudong, Oh, Goo Taeg, Park, Jong-Gil, Yu, Jinha   +5 more
core   +1 more source

Implementing physician‐led medication reviews for patients with diabetes and severe mental disorder: A randomized controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Patients with severe mental disorder and diabetes may be exposed to inappropriate polypharmacy increasing the risk of side effects and drug interactions. Although medication reviews may facilitate short‐term deprescribing, they are not known to affect clinical outcomes.
Johan Frederik Mebus Meyer Christensen, Signe Wegmann Düring, Gesche Jürgens   +2 more
wiley   +1 more source

Enhancement of retinal Müller glia's phagocytic activity against hard exudates by conbercept <i>via</i> activation of PPARγ-CD36 axis in diabetic retinopathy. [PDF]

Int J Ophthalmol
Zhu YY, Qin SY, Xie H, Liu YP, Li XS, Zhang CY, Zhang YC, Zhang JF.   +7 more
europepmc   +1 more source

Apolipoproteins and lipoprotein receptors in glomeruli in human kidney diseases.

Kidney International, 1993
T. Takemura, K. Yoshioka, K. Yoshioka, N. Aya, N. Aya, K. Murakami, K. Murakami, Akiyo Matumoto, Akiyo Matumoto, H. Itakura, H. Itakura, Tatsuhiko Kodama, Tatsuhiko Kodama, H. Suzuki, Hiroshi Suzuki, S. Maki, S. Maki   +16 more
semanticscholar   +1 more source

Use of LC‐MS to characterize host cell protein removal during depth filtration

Biotechnology Progress, EarlyView.
Abstract The removal of host cell proteins (HCPs) is crucial in biopharmaceutical production, as residual impurities can impact product safety and efficacy. While a number of studies have demonstrated that depth filtration can provide significant HCP removal, there is little information on its effectiveness in removing specific HCPs.
Liang‐Kai Chu, Ehsan Espah Borujeni, Xuankuo Xu, Andrew L. Zydney   +3 more
wiley   +1 more source

Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability. [PDF]

J Nanobiotechnology
Liu S, Jin X, Ge Y, Dong J, Liu X, Pei X, Wang P, Wang B, Chang Y, Yu XA.   +9 more
europepmc   +1 more source

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Cancer Communications, EarlyView.
Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu   +11 more
wiley   +1 more source

Homozygous Familial Hypercholesterolemia in a Seven-Year-Old: A Case Study Highlighting the Importance of Early Diagnosis. [PDF]

Cureus
Bensabbahia D, El Achiwi M, Atrassi M, Abkari A, Widad G.   +4 more
europepmc   +1 more source