Results 211 to 220 of about 127,504 (263)
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Lipoprotein receptors and atherosclerosis
Biochemical Society Transactions, 1989The whole lipoprotein spectrum of human plasma may be divided into atherosclerotic and anti-atherosclerotic lipoproteins. To the first class belong apolipoprotein (apo) B and some apoE-containing lipoproteins of the very-low-density (VLDL), intermediate-density (IDL) and low-density (LDL) lipoprotein fractions.
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The Lipoprotein Receptor Concept
Drugs, 1988The interaction of plasma lipoproteins with mammalian cells is facilitated by specific receptors on the cell surface. The chylomicron remnant receptor recognises apolipoprotein E (apo E) and mediates the uptake of chylomicron remnants by the liver. The low density lipoprotein (LDL) receptor recognises lipoproteins containing apolipoprotein B100 or an ...
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Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism
Hepatology, 1988Hepatocytes, as the major site of synthesis and terminal catabolism of plasma lipoproteins, exert the major regulatory influence on the concentration of atherogenic lipoproteins in blood plasma and may thereby influence the rate of atherogenesis. The LDL receptor on the microvillous sinusoidal surface of hepatocytes mediates the catabolism of remnants ...
R J, Havel, R L, Hamilton
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Lipoprotein and receptor interactions in vivo
Current Opinion in Lipidology, 1995A substantial number of animal models aimed at the genetic dissection of lipid metabolism have been generated recently. Transgenic and knockout mice, in which the receptors or apolipoproteins are overexpressed or destroyed, combined with virus-mediated gene transfer in vivo have advanced our understanding of the complex physiological and ...
J, Herz, T E, Willnow
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Lipoprotein receptors in the vascular wall
Current Opinion in Lipidology, 2004We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall.Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the endothelium, macrophages and smooth muscle cells communicate with ...
Joachim, Herz, David Y, Hui
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Lipoprotein Receptors and Endothelial Cells
Seminars in Thrombosis and Hemostasis, 1988The interaction of lipoproteins with endothelial receptors can result in alterations in macromolecular transport, in changes in monocyte adherence to the endothelium, and in the production of monocyte chemotactic factor by the endothelium. Monocyte migration in response to such factors can further alter lipoprotein transport into the subendothelial ...
A M, Fogelman +4 more
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Cellular signalling by lipoprotein receptors
Current Opinion in Lipidology, 2000Lipoprotein receptors are commonly thought merely to mediate the internalization of lipoprotein particles or the exchange of lipids at the cell surface. Recent findings have now implicated these multifunctional receptors in cellular signalling mechanisms that extend beyond simple ligand endocytosis.
J, Herz, M, Gotthardt, T E, Willnow
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Lipoprotein Receptors in the Nervous System
Annual Review of Biochemistry, 2002▪ Abstract The low-density–lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease ...
Joachim, Herz, Hans H, Bock
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Lipoprotein receptors: therapeutic implications
Journal of Hypertension, 1990Knowledge of the transport pathways for cholesterol in blood helps us to understand the mechanisms underlying genetic and acquired forms of hypercholesterolaemia, and sets the stage for rational treatment with diet and drugs. A key element is a cell-surface receptor that binds cholesterol-rich lipoproteins of intermediate and low density.
M S, Brown, J L, Goldstein
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Lipoprotein receptors and atherogenic receptor-mediated mechanisms
Current Opinion in Lipidology, 1994The liver plays a decisive role in the regulation of the plasma levels of atherogenic lipoproteins. The primary liver interaction site of chylomicron remnants and VLDL remnants (beta-VLDL) is still unidentified, whereas the subsequent cellular uptake is likely to be mediated in concert by the LDL receptor-related protein and the LDL receptor.
T J, van Berkel +3 more
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