Results 71 to 80 of about 2,558,356 (334)

Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes

open access: yesLipids in Health and Disease, 2005
Background Transport of fatty acids within the cytosol of adipocytes and their subsequent assimilation into lipid droplets has been thoroughly investigated; however, the mechanism by which fatty acids are transported across the plasma membrane from the ...
Orlando Robert A   +3 more
doaj   +1 more source

Structural and RNAi characterization of the German cockroach lipophorin receptor, and the evolutionary relationships of lipoprotein receptors

open access: yesBMC Molecular Biology, 2007
BackgroundLipophorin receptors (LpRs) have been described in a number of insects, but functional studies have been reported only in locusts and mosquitoes.
Laura Ciudad, X. Belles, M. Piulachs
semanticscholar   +1 more source

Association Between Metabolic Syndrome and Radiographic Changes in Psoriatic Arthritis: A Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective Metabolic syndrome (MetS) is a known comorbidity of psoriatic arthritis (PsA) and is associated with PsA disease activity. We aimed to explore the association between MetS and radiographic features (peripheral and axial) in PsA. Methods We included patients with PsA followed at our prospective observational cohort for the period between 1978 ...
Fadi Kharouf   +6 more
wiley   +1 more source

Effect of pregnancy and lactation on lipoprotein and cholesterol metabolism in the rat

open access: yesJournal of Lipid Research, 1998
Origins of hyperlipidemia and cholestasis that occur during pregnancy were investigated by examining expression of key elements related to plasma and hepatic cholesterol metabolism during pregnancy, lactation, and post-lactation in the rat model.
Jeffery L. Smith   +5 more
doaj  

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1981
Liver membranes from young beagle dogs were found to possess binding sites that resemble the low density lipoprotein (LDL) receptors originally described in cultured human fibroblasts.
P. Kovanen   +4 more
semanticscholar   +1 more source

Structure and dynamics of dynorphin peptide and its receptor [PDF]

open access: yesarXiv, 2019
Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv  

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

open access: yesAdvanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu   +6 more
wiley   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray   +2 more
wiley   +1 more source

Cell-associated heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake[S]

open access: yesJournal of Lipid Research, 2019
Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets the LDL receptor (LDLR) for degradation, increasing plasma LDL and, consequently, cardiovascular risk.
Adri M. Galvan, John S. Chorba
doaj  

Lipoprotein Lipase Binds to Low Density Lipoprotein Receptors and Induces Receptor-mediated Catabolism of Very Low Density Lipoproteins in Vitro*

open access: yesJournal of Biological Chemistry, 1996
Lipoprotein lipase (LPL), the major enzyme responsible for the hydrolysis of plasma triglycerides, promotes binding and catabolism of triglyceride-rich lipoproteins by various cultured cells.
J. Medh   +8 more
semanticscholar   +1 more source

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